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Find Clinical Drug Pipeline Developments & Deals for Calquence
Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.
The two companies will jointly conduct Phase III of the Bcl-2 inhibitor, APG-2575 (lisaftoclax), in combination with AstraZeneca's BTK inhibitor, Calquence (acalabrutinib), in treatment-naive patients with first-line chronic lymphocytic leukemia/small lymphocytic lymphoma.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). It has been approved in China for the treatment of chronic lymphocytic leukaemia or small lymphocytic lymphoma who have received at least one prior therapy.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). It has been granted first regulatory approval in china for adults with previously treated mantle cell lymphoma.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). Its tablet formulation has been approved in the EU for patients with chronic lymphocytic leukaemia.
Calquence (acalabrutinib), a next-generation, selective inhibitor of BTK, binds covalently to BTK, thereby inhibiting its activity. In B cells, BTK signalling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis and adhesion.
In the trials, results showed the CALQUENCE capsule and tablet formulations are bioequivalent, indicating the same efficacy and safety profile can be expected with the same dosing strength and schedule.
Updated data from ELEVATE-TN Phase III trial at five years, will highlight longer-term safety, PFS efficacy results and OS rates for Calquence (Acalabrutinib) in combination with obinutuzumab and alone compared to obinutuzumab plus chlorambucil in adults with CLL.
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