Lead Product(s) : Lunresertib,Camonsertib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Repare Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Foundation Medicine Partners with Repare for Genomic Profiling and Companion Diagnostic
Details : The collaboration aims to support Repare’s ongoing clinical development of RP-6306 (lunresertib) oral small molecule inhibitor of PKMYT1 alone or with camonsertib for the treatment of neoplasms.
Brand Name : RP-6306
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 12, 2024
Lead Product(s) : Lunresertib,Camonsertib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Repare Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Repare Therapeutics Doses First Patient in Camonsertib NSCLC Trial
Details : RP-3500 (camonsertib), a potential best-in-class oral small molecule inhibitor of ATR (Ataxia-Telangiectasia and Rad3-related protein kinase). It is evaluated for non-small cell lung cancer.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 10, 2024
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Lunresertib,Camonsertib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Repare's Lunresertib Gets FDA Fast Track for Platinum-Resistant Ovarian Cancer
Details : FDA granted Fast Track designation to RP-6306 (lunresertib) in combination with RP-3500 (camonsertib) for CCNE1 amplified, or FBXW7 or PPP2R1A-mutated platinum-resistant ovarian cancer.
Brand Name : RP-6306
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 04, 2024
Lead Product(s) : Lunresertib,Camonsertib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : $1,325.0 million
Deal Type : Termination
Repare Therapeutics to Regain Global Rights to Camonsertib
Details : Repare regains global rights to RP-3500 (camonsertib), a potential best-in-class ATR inhibitor, after a termination of a partnership.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : $125.0 million
February 12, 2024
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : $1,325.0 million
Deal Type : Termination
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : $1,338.6 million
Deal Type : Licensing Agreement
Repare Therapeutics Announces Achievement of $40 Million Roche Clinical Milestone Payment
Details : Roche is responsible for developing RP-3500/RG6526 (camonsertib), a selective oral small molecule inhibitor of ATR for treating tumors with synthetic-lethal genomic alterations.
Brand Name : RG6526
Molecule Type : Small molecule
Upfront Cash : $125.0 million
January 25, 2024
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : $1,338.6 million
Deal Type : Licensing Agreement
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Repare Therapeutics to Present New Clinical and Preclinical Data at the 2022 AACR Annual Meeting
Details : RP-3500 is a potent and selective oral small molecule inhibitor of ATR being developed for treatment of solid tumors with specific genome instability related genomic alterations including those in the ATM (ataxia-telangiectasia mutated) gene.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 08, 2022
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : RP-3500, orally-administered ataxia telangiectasia and Rad3-related inhibitor currently in Phase 1/2 TRESR trial clinical development in patients with DNA damage repair, loss-of-function and mutant tumors.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 08, 2022
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Dose optimization provides robust evidence to advance RP-3500, a potent and selective oral small molecule inhibitor of ATR into Phase 2 studies with a recommended dose and schedule, for the treatment of solid tumors.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 07, 2022
Lead Product(s) : Camonsertib,Talazoparib,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Camonsertib,Talazoparib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Repare Therapeutics Announces Dosing of First Patient in Phase 1/2 Clinical Trial of RP-3500
Details : RP-3500 is a potent and selective oral small molecule inhibitor of ATR being developed for the treatment of solid tumors with selected genomic alterations.
Brand Name : RP-3500
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 29, 2020
Lead Product(s) : Camonsertib,Talazoparib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Versant Ventures
Deal Size : $100.0 million
Deal Type : Public Offering
Preclinical Oncology Biotech Repare Therapeutics Files for a $100 Million IPO
Details : Repare intends to file an IND application in the 2Q20 for lead candidate,RP-3500, an oral small molecule inhibitor for the treatment of solid tumors.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 29, 2020
Lead Product(s) : Camonsertib
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Versant Ventures
Deal Size : $100.0 million
Deal Type : Public Offering
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