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    [{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Canakinumab","moa":"IL-1-beta receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Novartis Pharmaceuticals Corporation","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Novartis Pharmaceuticals Corporation \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Novartis Pharmaceuticals Corporation \/ Inapplicable"},{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Canakinumab","moa":"||IL-1-beta 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    01

    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis Provides Update on Phase III Canopy-a Study Evaluating Canakinumab as Adjuvant Treatment in Non-small...

    Details : canakinumab (ACZ885/Ilaris), is a human monoclonal antibody that binds with high affinity and selectivity to human IL-1β and inhibits IL-1β activity by blocking its interaction with its receptors.

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    August 15, 2022

    Lead Product(s) : Canakinumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab,Carboplatin

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis Top-Line Results for CANOPY-1 Phase III Study Support Further Evaluation of Canakinumab in Lung Cance...

    Details : Canakinumab is a human monoclonal antibody that binds with high affinity and selectivity to human interleukin-1beta (IL-1β) and neutralizes IL-1β activity by blocking its interaction with its receptors.

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    October 25, 2021

    Lead Product(s) : Canakinumab,Carboplatin

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab,Docetaxel

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis Gives Update on Phase III Study of Canakinumab and Chemotherapy Combo as 2nd or 3rd-Line Treatment in...

    Details : Novartis announced that the Phase III CANOPY-2 study evaluating canakinumab (ACZ885), an inhibitor of interleukin-1beta (IL-1β), in combination with the chemotherapy agent docetaxel, did not meet its primary endpoint of overall survival (OS).

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    September 03, 2021

    Lead Product(s) : Canakinumab,Docetaxel

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Immunology

    Study Phase : Approved FDF

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Ilaris® Receives Health Canada Approval as First of Its Kind Treatment for Rare, Inflammatory Disorder, Adult...

    Details : This new indication follows the existing approval of Ilaris for Systemic Juvenile Idiopathic Arthritis (SJIA)1, now allowing patients over the age of 16 to be treated. Ilaris is an interleukin-1 beta inhibitor that provides a new mode of treatment for th...

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    April 29, 2021

    Lead Product(s) : Canakinumab

    Therapeutic Area : Immunology

    Highest Development Status : Approved FDF

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    05

    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : LNA043,Canakinumab

    Therapeutic Area : Musculoskeletal

    Study Phase : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    US FDA Grants Fast Track Designation to Novartis’ LNA043 for Treatment for Osteoarthritis of the Knee

    Details : LNA043 is a ANGPTL3 agonist that targets damaged cartilage and modulates several pathways involved in cartilage regeneration. LNA043 resulted in regeneration of damaged cartilage in patients with femoral articular cartilage lesions in a proof of concept ...

    Product Name : LNA043

    Product Type : Protein

    Upfront Cash : Inapplicable

    February 09, 2021

    Lead Product(s) : LNA043,Canakinumab

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Immunology

    Study Phase : Approved FDF

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    FDA Approves First Treatment for Adult Onset Still’s Disease, a Severe and Rare Disease

    Details : The U.S. Food and Drug Administration approved Ilaris (canakinumab) injection for the treatment of Active Still’s disease, including Adult-Onset Still’s Disease (AOSD).

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    June 16, 2020

    Lead Product(s) : Canakinumab

    Therapeutic Area : Immunology

    Highest Development Status : Approved FDF

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Infections and Infectious Diseases

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis Provides Update on CAN-COVID Trial in Hospitalized Patients with Covid-19 Pneumonia and Cytokine Rele...

    Details : The Phase III trial investigating canakinumab plus standard of care did not meet its primary endpoint of a greater chance of patient survival without the need for invasive mechanical ventilation, or its key secondary endpoint of reduced COVID-19 mortalit...

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    June 11, 2020

    Lead Product(s) : Canakinumab

    Therapeutic Area : Infections and Infectious Diseases

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Novartis Pharmaceuticals Corporation

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Infections and Infectious Diseases

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis Plans COVID-19 Testing for Ilaris

    Details : The CAN-COVID trial will examine the efficacy of utilizing canakinumab, to treat a type of severe immune overreaction called cytokine release syndrome in people with COVID-19 pneumonia.

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    April 28, 2020

    Lead Product(s) : Canakinumab

    Therapeutic Area : Infections and Infectious Diseases

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Canakinumab

    Therapeutic Area : Cardiology/Vascular Diseases

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Novartis’ Ilaris [Canakinumab] Unexpectedly Slashes Need For Joint Replacements From Osteoarthritis In Key S...

    Details : In a study of Ilaris in 10,000 patients with a history of heart attack it is found that people taking the drug had 40% to 47% lower rates of total knee or hip replacements than did those taking a placebo.

    Product Name : Ilaris

    Product Type : Antibody

    Upfront Cash : Inapplicable

    March 08, 2020

    Lead Product(s) : Canakinumab

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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