[{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Citigroup","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2024","type":"Public Offering","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase III","graph3":"Candel Therapeutics","amount2":0.089999999999999997,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.089999999999999997,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Citigroup","highestDevelopmentStatusID":"10","companyTruncated":"Candel Therapeutics \/ Citigroup"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"IDEA Pharma Ltd","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2025","type":"Partnership","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase III","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ IDEA Pharma Ltd","highestDevelopmentStatusID":"10","companyTruncated":"Candel Therapeutics \/ IDEA Pharma Ltd"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2021","type":"Public Offering","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase III","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Candel Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Silicon Valley Bank","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2022","type":"Financing","leadProduct":"Aglatimagene Besadenovec","moa":"DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Silicon Valley Bank","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Silicon Valley Bank"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"University of Pennsylvania","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Partnership","leadProduct":"Undisclosed","moa":"||Undisclosed","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Candel Therapeutics \/ University of Pennsylvania","highestDevelopmentStatusID":"3","companyTruncated":"Candel Therapeutics \/ University of Pennsylvania"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2024","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel 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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2023","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2023","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2023","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2024","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"||DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel 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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Inapplicable","leadProduct":"CAN-3110","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Candel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Candel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Candel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"Aglatimagene Besadenovec","moa":"DNA polymerase","graph1":"Oncology","graph2":"Phase II","graph3":"Candel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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                          Top Deals by Deal Size (USD bn)

                          01

                          Plastics Recycling EU
                          Not Confirmed
                          Plastics Recycling EU
                          Not Confirmed

                          Details : Under this partnership, IDEA will provide strategic commercial input throughout the development and commercialization process for Candel’s lead asset, CAN-2409 (aglatimagene besadenovec).

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Undisclosed

                          March 20, 2025

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : IDEA Pharma Ltd

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          02

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 (aglatimagene besadenovec) a gene therapy which constructs encoding for thymidine kinase gene. It is being evaluated for the treatment of non-metastatic pancreatic cancer.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          February 25, 2025

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Plastics Recycling EU
                          Not Confirmed
                          Plastics Recycling EU
                          Not Confirmed

                          Details : The net proceeds from the offering will be used to continue developing product candidates, including preparing the submission of a BLA for CAN-2409 (aglatimagene besadenovec) in prostate cancer.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Undisclosed

                          December 16, 2024

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Citigroup

                          Deal Size : $92.0 million

                          Deal Type : Public Offering

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                          04

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 (aglatimagene besadenovec) a gene therapy which constructs encoding for thymidine kinase gene. It is being evaluated with valacyclovir for prostate cancer.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 is an investigational replication-defective adenovirus delivering the HSV-tk gene, combined with valacyclovir, being studied for pancreatic cancer treatment.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          November 04, 2024

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-3110 is a first-in-class, replication-competent HSV-1 oncolytic viral immunotherapy candidate for the treatment of patients with recurrent high-grade glioma to improve overall survival.

                          Product Name : CAN-3110

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          May 30, 2024

                          Lead Product(s) : CAN-3110,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 (aglatimagene besadenovec) is an adenoviral replication-defective engineered gene, evaluated with valacyclovir for borderline resectable pancreatic cancer.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          April 04, 2024

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 (aglatimagene besadenovec) a gene therapy which constructs encoding for thymidine kinase gene. It is being evaluated with valacyclovir for borderline resectable pancreatic adenocarcinoma.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          March 06, 2024

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-3110 is an oncolytic viral immunotherapy based on HSV-1, developed for recurrent high-grade glioma to improve overall survival.

                          Product Name : CAN-3110

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          February 13, 2024

                          Lead Product(s) : CAN-3110,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : CAN-2409 (aglatimagene besadenovec) plus valacyclovir is a replication-defective adenovirus that is designed to deliver the herpes simplex virus thymidine kinase (HSV-tk) gene to cancer cells.

                          Product Name : CAN-2409

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          December 12, 2023

                          Lead Product(s) : Aglatimagene Besadenovec,Valacyclovir

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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