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Find Clinical Drug Pipeline Developments & Deals by Caraway Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : Through the acquisition, Merck gains Caraway's pipeline of novel, small-molecule therapeutics for the treatment of genetically defined neurodegenerative and rare diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          November 21, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Merck & Co

                          Deal Size : $610.0 million

                          Deal Type : Acquisition

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                          02

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : TRPML1, a member of the transient receptor potential ion channel superfamily, targeting the lysosomal cation channel for the treatment of GBA-PD and other neurodegenerative diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 03, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : TRPML1 is a non-selective cation channel that contributes to the regulation of lysosomal ionic contents and mediates communication with the rest of the cell.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          June 10, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : TRPML1 normally functions to regulate and maintain the ionic composition in the lysosome, and mutations in TRPML1 lead to Mucolipidosis Type IV, which is typified by lysosomal dysfunction and toxic accumulation of proteins and lipids that have not been e...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          June 07, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Study Phase : Preclinical

                          Sponsor : The Michael J. Fox Foundation for Parkinson’s Research

                          Deal Size : Undisclosed

                          Deal Type : Funding

                          Details : The Company will use the grant funding to further evaluate these effects and characterize potential biomarkers which may be used in future clinical trials of TRPML1 activators.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          January 26, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : The Michael J. Fox Foundation for Parkinson’s Research

                          Deal Size : Undisclosed

                          Deal Type : Funding

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                          06

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : Collaboration to focus on development of TMEM175 modulators in Parkinson’s disease and other neurodegenerative disorders. Leverages Caraway’s unique drug discovery platform and expertise in cellular clearance.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $17.0 million

                          September 06, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : AbbVie Inc

                          Deal Size : $267.0 million

                          Deal Type : Collaboration

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