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\/ Inapplicable"},{"orgOrder":0,"company":"Vectura Ltd","sponsor":"Aerami Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2020","type":"Agreement","leadProduct":"Imatinib Mesylate","moa":"ABL1","graph1":"Cardiology\/Vascular Diseases","graph2":"IND Enabling","graph3":"Vectura Ltd","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"Vectura Ltd \/ Aerami Therapeutics","highestDevelopmentStatusID":"5","companyTruncated":"Vectura Ltd \/ Aerami Therapeutics"},{"orgOrder":0,"company":"Inhibikase Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Imatinib Mesylate Prodrug","moa":"ABL 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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Details : Aerami will be responsible for the overall development and commercialisation of inhaled imatinib, with Vectura providing development services expertise and a license to its FOX® mesh nebuliser technology.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 06, 2020

                          Lead Product(s) : Imatinib Mesylate

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Aerami Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Skyepharma Company Banner

                          02

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : T20G is a non-vitamin K antagonist oral anticoagulant (NOAC) product, which is currently being evaluated for the treatment of atrial fibrillation.

                          Product Name : T20G

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          March 20, 2025

                          Lead Product(s) : T20G

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : Potential best-in-class gene therapy, one-time intravenous injection, AFTX-201 (BAG3 protein levels enhancer), is being investigated for the treatment of BAG3 dilated cardiomyopathy.

                          Product Name : AFTX-201

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : AFTX-201

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : UDP-003 is a first-in-class drug; a specially engineered cyclodextrin which will target and remove toxic oxidized cholesterol, a key driver of acute coronary syndrome.

                          Product Name : UDP-003

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 07, 2025

                          Lead Product(s) : Cyclodextrin

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Monash University

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : CG-0255 is an advanced P2Y12 receptor antagonist developed as a next-generation antiplatelet therapy, for the treatment of coronary artery disease.

                          Product Name : CG-0255

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 12, 2024

                          Lead Product(s) : Benzenesulfonic Acid

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : STP125G is a single-stranded siRNA therapeutics targeting ApoC3 mRNA, based on Sirnaomics proprietary GalAhead™ mxRNA technology.

                          Product Name : STP125G

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          November 07, 2024

                          Lead Product(s) : STP125G

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : HiCM-188 is the first investigational iPSC-derived cell therapy to undergo clinical evaluation for the treatment of end-stage heart failure.

                          Product Name : HiCM-188

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 22, 2024

                          Lead Product(s) : HiCM-188

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The proceeds will be used to finance the initiation of a Phase 2b trial in pulmonary arterial hypertension evaluating IkT-001Pro, a prodrug of imatinib mesylate.

                          Product Name : IKT-001PRO

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 21, 2024

                          Lead Product(s) : Imatinib Mesylate Prodrug

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : $275.0 million

                          Deal Type : Private Placement

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                          09

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : Under the license agreement, Genevant will grant Repair a nonexclusive worldwide license to certain LNP technology to exploit CDP mRNA products for a specified field that includes atherosclerosis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 26, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Repair Biotechnologies

                          Deal Size : $107.0 million

                          Deal Type : Licensing Agreement

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                          10

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The proceeds will be used to finance the initiation of a Phase 2b trial in pulmonary arterial hypertension evaluating IkT-001Pro, a prodrug of imatinib mesylate.

                          Product Name : IKT-001PRO

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          September 10, 2024

                          Lead Product(s) : Imatinib Mesylate Prodrug

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Soleus Capital

                          Deal Size : $110.0 million

                          Deal Type : Private Placement

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