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I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0.050000000000000003,"dosageForm":"Intravenous Infusion","sponsorNew":"Tenaya Therapeutics \/ Leerink Partners","highestDevelopmentStatusID":"7","companyTruncated":"Tenaya Therapeutics \/ Leerink Partners"},{"orgOrder":0,"company":"XyloCor Therapeutics","sponsor":"Jeito Capital","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Series B Financing","leadProduct":"Encoberminogene Rezmadenovec","moa":"GRP78 upregulation pathway","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I\/ Phase II","graph3":"XyloCor Therapeutics","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0.070000000000000007,"dosageForm":"Undisclosed","sponsorNew":"XyloCor Therapeutics \/ Jeito Capital","highestDevelopmentStatusID":"7","companyTruncated":"XyloCor Therapeutics \/ Jeito Capital"},{"orgOrder":0,"company":"Lexeo Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"LX2006","moa":"FXN","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I\/ Phase II","graph3":"Lexeo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Lexeo Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Lexeo Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"BioCardia","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Bone Marrow-derived Mesenchymal Stem Cells","moa":"Undisclosed","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I\/ Phase II","graph3":"BioCardia","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Transendocardial Injection","sponsorNew":"BioCardia \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BioCardia \/ Inapplicable"}]

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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : CardiALLO (Human Allogenic Culture-expanded Bone marrow-derived Mesenchymal Stem Cell) is under phase 1/2 clinical development for the treatment of ischemic heart failure of reduced ejection fraction.

                          Product Name : CardiALLO

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 15, 2025

                          Lead Product(s) : Bone Marrow-derived Mesenchymal Stem Cells

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : LX2006 is an AAV-based gene therapy candidate. Currently, it is being evaluated for the treatment of Friedreich Ataxia cardiomyopathy.

                          Product Name : LX2006

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 07, 2025

                          Lead Product(s) : LX2006

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : SRD-001 is an adeno-associated virus mediated gene transfer that contains an engineered version of the SERCA2a gene for the treatment of heart failure.

                          Product Name : SRD-001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 20, 2025

                          Lead Product(s) : SRD-001

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : SRD-001 is an adeno-associated virus mediated gene transfer that contains an engineered version of the SERCA2a gene for the treatment of heart failure.

                          Product Name : SRD-001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 11, 2025

                          Lead Product(s) : SRD-001

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Tenaya intends to fund the development of its clinical and early-stage candidates, particularly TN-201, a gene therapy for MYBPC3-associated HCM and TN-401 for PKP2-associated ARVC.

                          Product Name : TN-201

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 03, 2025

                          Lead Product(s) : TN-201

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Leerink Partners

                          Deal Size : $52.5 million

                          Deal Type : Public Offering

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Lead Product(s) : Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cell

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Study Phase : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : CardiALLO (Human Allogenic Culture-expanded Bone marrow-derived Mesenchymal Stem Cell) is under phase 1/2 clinical development for the treatment of ischemic heart failure of reduced ejection fraction.

                          Product Name : CardiALLO

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 13, 2025

                          Lead Product(s) : Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cell

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : MAR001 is a potential first-in-class monoclonal antibody that targets ANGPTL4, a protein that is highly expressed in adipose tissue. It is being evaluated for the treatment of hypertriglyceridemia.

                          Product Name : MAR001

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : MAR001

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The financing will support the company in advancing the clinical development of XC001 (encoberminogene rezmadenovec) for the treating Refractory Angina.

                          Product Name : XC001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 07, 2025

                          Lead Product(s) : Encoberminogene Rezmadenovec

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Jeito Capital

                          Deal Size : $67.5 million

                          Deal Type : Series B Financing

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : BGC101 leverages BioGenCell's proprietary TRACT platform to develop personalized stem cell therapies. It is being evaluated for the treatment of chronic limb-threatening ischemia.

                          Product Name : BGC101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 19, 2024

                          Lead Product(s) : BGC101

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : TN-201 is being developed for the potential treatment of MYBPC3-associated hypertrophic cardiomyopathy (HCM), a condition caused by insufficient levels of myosin-binding protein C (MyBP-C)

                          Product Name : TN-201

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 16, 2024

                          Lead Product(s) : TN-201

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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