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Diseases","amount2New":0,"dosageForm":"Topical Gel","sponsorNew":"SolasCure \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"SolasCure \/ Inapplicable"},{"orgOrder":0,"company":"Amnio Technology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"URUGUAY","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"Palingen Flow","moa":"Undisclosed","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II","graph3":"Amnio Technology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Amnio Technology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Amnio Technology \/ Inapplicable"}]

    Find Drugs for Cardiology/Vascular Diseases in Phase II Clinical Development

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                            01

                            Novasep

                            Germany
                            BePharma
                            Not Confirmed
                            • fda
                            • EDQM
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                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : AAV1/SERCA2a

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Celladon

                            Deal Size : $5.4 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Novasep Signs €4.7m Biomanufacturing Deal with Biotech

                            Details : Through the agreement, Novasep will support Celladon’s plans to produce Mydicar, which is being evaluated in the mid-stage clinical trial for the treatment of heart failure.

                            Product Name : Mydicar

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            December 13, 2023

                            Lead Product(s) : AAV1/SERCA2a

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Celladon

                            Deal Size : $5.4 million

                            Deal Type : Agreement

                            Axplora Novasep

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                            02

                            AbbVie Inc

                            U.S.A
                            BePharma
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                            Lead Product(s) : Botulinum Toxin A

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            AbbVie Announces Late-Breaking Results from Phase 2 Exploratory NOVA Trial of Novel Investigational Neurotoxin...

                            Details : In a post hoc analysis of CABG patients aged 65 years and older treated with 125 units of AGN-151607, a botulinum toxin type A, is a novel investigational neurotoxin the study found a greater risk reduction at 51 percent compared to placebo (nominal p<0....

                            Product Name : AGN-151607

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            July 11, 2022

                            Lead Product(s) : Botulinum Toxin A

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            Abbvie Company Banner

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                            03

                            Sanofi

                            France
                            BIO International Convention
                            Exhibiting
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                            • EDQM
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                            Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

                            Lead Product(s) : Ataciguat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Rancho Santa Fe Bio

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Rancho Santa Fe Bio, Inc. Enters into Worldwide Exclusive License Agreement with Sanofi for Ataciguat

                            Details : This agreement provides RSF Bio with Sanofi’s rights to Ataciguat. With this license, RSF Bio will have the rights it needs to continue development of Ataciguat through clinical trials in the United States and potentially in select international countr...

                            Product Name : HMR1766

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 17, 2021

                            Lead Product(s) : Ataciguat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Rancho Santa Fe Bio

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            Sanofi Company Banner

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                            04

                            Jiangsu Hengrui Medicine

                            China arrow
                            BePharma
                            Not Confirmed

                            Jiangsu Hengrui Medicine

                            China arrow
                            BePharma
                            Not Confirmed
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                            Lead Product(s) : HRS-5346

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Merck & Co

                            Deal Size : $1,970.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Merck Licenses HRS-5346, Oral Lipoprotein(a) Inhibitor, from Jiangsu Hengrui

                            Details :

                            Product Name : HRS-5346

                            Product Type : Other Small Molecule

                            Upfront Cash : $200.0 million

                            March 25, 2025

                            Lead Product(s) : HRS-5346

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Merck & Co

                            Deal Size : $1,970.0 million

                            Deal Type : Licensing Agreement

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                            05

                            SolasCure

                            United Kingdom arrow
                            BePharma
                            Not Confirmed

                            SolasCure

                            United Kingdom arrow
                            BePharma
                            Not Confirmed
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                            Lead Product(s) : Tarumase

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SolasCure Enrols First Patient in Phase 2 Trial for Aurase Wound Gel

                            Details : Aurase Wound Gel is a hydrogel releasing Tarumase, a recombinant enzyme that selectively targets fibrin, collagen & elastin in wounds to promote healing through debridement.

                            Product Name : Aurase Wound Gel

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 17, 2025

                            Lead Product(s) : Tarumase

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Zhejiang Doer Biologics

                            China arrow
                            BePharma
                            Not Confirmed

                            Zhejiang Doer Biologics

                            China arrow
                            BePharma
                            Not Confirmed
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                            Lead Product(s) : DR10624

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Doer Biologics Completes Enrollment of the Phase 2 Clinical Study of DR10624

                            Details : DR10624 is first-in-class, tri-specific agonist targeting FGF21R, GCGR, GLP-1R. It is being evaluated for the treatment of severe hypertriglyceridemia.

                            Product Name : DR10624

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            March 09, 2025

                            Lead Product(s) : DR10624

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Revalesio

                            U.S.A arrow
                            BePharma
                            Not Confirmed

                            Revalesio

                            U.S.A arrow
                            BePharma
                            Not Confirmed
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                            Lead Product(s) : RNS60

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Revalesio to Present New Phase 2 RESCUE Data on RNS60 in Ischemic Stroke

                            Details : RNS60 activates intracellular signaling pathways to increase mitochondrial biogenesis and function and reduce inflammation. It is being investigated for acute ischemic stroke.

                            Product Name : RNS60

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 05, 2025

                            Lead Product(s) : RNS60

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Mineralys Therapeutics

                            U.S.A arrow
                            BePharma
                            Not Confirmed

                            Mineralys Therapeutics

                            U.S.A arrow
                            BePharma
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                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Mineralys Completes Enrollment in Explore-CKD Phase 2 Lorundrostat Trial

                            Details : MLS-101 (lorundrostat) is a proprietary, orally administered, highly selective aldosterone synthase inhibitor being developed for the treatment of uncontrolled hypertension or resistant hypertension.

                            Product Name : MT-4129

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 04, 2025

                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Salubris Biotherapeutics

                            U.S.A arrow
                            BePharma
                            Not Confirmed

                            Salubris Biotherapeutics

                            U.S.A arrow
                            BePharma
                            Not Confirmed
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                            Lead Product(s) : JK07

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Salubris Biotherapeutics Announces Positive Interim Data for JK07 in Heart Failure

                            Details : JK07 is a recombinant fusion protein consisting of a fully human IgG1 monoclonal antibody, which is being evaluated for the treatment of patients with HFrEF and HFpEF.

                            Product Name : JK07

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 22, 2025

                            Lead Product(s) : JK07

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Keros Therapeutics

                            U.S.A arrow
                            BePharma
                            Not Confirmed

                            Keros Therapeutics

                            U.S.A arrow
                            BePharma
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                            Lead Product(s) : Cibotercept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Keros Ends Hypertension Trial Over Fluid Buildups Around Heart

                            Details : KER-012 (cibotercept) is designed to bind to and inhibit the signaling of TGF-β ligands that stimulate smooth muscle hypertrophy and fibrosis, including activin A, activin B and myostatin.

                            Product Name : KER-012

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 15, 2025

                            Lead Product(s) : Cibotercept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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