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                            01

                            BioCardia

                            U.S.A arrow
                            Pharmtech & Ingredients
                            Not Confirmed

                            BioCardia

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioCardia Completes Phase 3 Cell Therapy Trial for Heart Failure

                            Details : CardiAMP cell therapy is the first treatment utilizing patient's own cells for the treatment. It is being evaluated for treating ischemic etiology heart failure of reduced ejection fraction.

                            Brand Name : CardiAMP

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 28, 2024

                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Alnylam Pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Vutrisiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alnylam Submits Application for Vutrisiran in ATTR Cardiomyopathy

                            Details : Amvuttra (vutrisiran) is an investigational RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM).

                            Brand Name : Amvuttra

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 16, 2024

                            Lead Product(s) : Vutrisiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Xyra

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Xyra

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Budiodarone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            XYRA Gains FDA Guidance on Atrial Fibrillation Management with Budiodarone

                            Details : ATI-2042 (budiodarone) is a potentially best-in-class mixed ion channel blocker. It is being evaluated for the treatment of symptomatic non-permanent atrial fibrillation.

                            Brand Name : ATI-2042

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 16, 2024

                            Lead Product(s) : Budiodarone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Alnylam Pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Vutrisiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alnylam Submits sNDA For Vutrisiran For Transthyretin Amyloidosis Treatment

                            Details : Amvuttra (vutrisiran) is an investigational RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM).

                            Brand Name : Amvuttra

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 09, 2024

                            Lead Product(s) : Vutrisiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            InCarda Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed

                            InCarda Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Flecainide

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InCarda Announces RESTORE-1 Phase 3 Trial Results and Continued Development Plans

                            Details : FlecIH-103 is a novel inhaled drug designed to rapidly deliver flecainide acetate, to the heart via the lungs to restore normal sinus rhythm in patient’s symptoms recurrent PAF.

                            Brand Name : FlecIH-103

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 30, 2024

                            Lead Product(s) : Flecainide

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Lexicon pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Lexicon pharmaceuticals

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Sotagliflozin

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Gardasil Approved for Prevention of HPV-Caused Cancers

                            Details : Inpefa (sotagliflozin) is a small molecule dual inhibitor of SGLT1 and SGLT2, which is indicated for the treatment of heart failure in patients with type 1 diabetes.

                            Brand Name : Inpefa

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 03, 2024

                            Lead Product(s) : Sotagliflozin

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Tenax Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Tenax Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Levosimendan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : BVF Partners LP

                            Deal Size : $100.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Tenax Therapeutics Closes $100M Private Placement to Accelerate Levosimendan Phase 3

                            Details : The funding will support the advancement of oral TNX-103 (levosimendan) phase 3 development program for the treatment of Pulmonary Hypertension Due to Heart Failure with Preserved Ejection Fraction.

                            Brand Name : TNX-103

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 12, 2024

                            Lead Product(s) : Levosimendan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : BVF Partners LP

                            Deal Size : $100.0 million

                            Deal Type : Private Placement

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                            08

                            Tenax Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Tenax Therapeutics

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Levosimendan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : BVF Partners LP

                            Deal Size : $100.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Tenax Therapeutics Announces Oversubscribed $100 Million Private Placement

                            Details : The Company intends to use the net proceeds from the private placement to complete its ongoing late-stage clinical trial studies with Patients for the treatment of PH-HFpEF.

                            Brand Name : TNX-103

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 06, 2024

                            Lead Product(s) : Levosimendan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : BVF Partners LP

                            Deal Size : $100.0 million

                            Deal Type : Private Placement

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                            09

                            Bayer AG

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Bayer AG

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Finerenone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Finerenone Meets Endpoint in Phase III FINEARTS-HF Study for Heart Failure

                            Details : Kerendia (finerenone) is a non-steroidal, selective mineralocorticoid receptor antagonist, being evaluated for heart failure with mildly reduced or preserved ejection fraction.

                            Brand Name : Kerendia

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 05, 2024

                            Lead Product(s) : Finerenone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Eli Lilly

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                            Pharmtech & Ingredients
                            Not Confirmed

                            Eli Lilly

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                            Pharmtech & Ingredients
                            Not Confirmed
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                            Lead Product(s) : Tirzepatide

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Lilly’s Tirzepatide Shows Benefit in Phase 3 Study for Heart Failure and Obesity

                            Details : Zepbound (tirzepatide) injection is an obesity treatment targeting GIP and GLP-1 hormone receptors. Currently being studied for adults with heart failure with preserved ejection fraction and obesity.

                            Brand Name : Zepbound

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            August 01, 2024

                            Lead Product(s) : Tirzepatide

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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