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therapy","year":"2024","type":"Financing","leadProduct":"TLT-101","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"TikkunLev Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"TikkunLev Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"TikkunLev Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Fauna Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Faun1083","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"Fauna Bio","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Fauna Bio \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Fauna Bio \/ Inapplicable"}]

Find Drugs for Cardiology/Vascular Diseases in Preclinical Development

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : The partmership aims to create improved treatment options for patients with complex medical needs, including PAH treatment with its first product candidate CO-254, a prodrug of treprostinil.

                          Product Name : CO-254

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 28, 2025

                          Lead Product(s) : Treprostinil Prodrug

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : InstantGMP

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          02

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Faun1083 is a potential first-in-class therapeutic targeting heart failure with preserved ejection fraction, a disease with currently limited treatment options.

                          Product Name : Faun1083

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 08, 2025

                          Lead Product(s) : Faun1083

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Through the collaboration, the two parties will jointly develop the small nucleic acid (siRNA) drug SNK-2726, which targets angiotensinogen (AGT) for the treatment of hypertension.

                          Product Name : Undisclosed

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          December 30, 2024

                          Lead Product(s) : SNK-2726

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : SynerK PharmaTech

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Under the agreement, Hansoh has granted Merck an exclusive global license to develop, manufacture and commercialize HS-10535, an investigational preclinical oral small molecule GLP-1 receptor agonist.

                          Product Name : HS-10535

                          Product Type : Small molecule

                          Upfront Cash : $112.0 million

                          December 18, 2024

                          Lead Product(s) : HS-10535

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Merck & Co

                          Deal Size : $2,012.0 million

                          Deal Type : Licensing Agreement

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                          05

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Solid to receive exclusive worldwide licenses to AAV-based Suppression-Replacement gene therapy platform and multiple next-generation cardiac gene therapy programs.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          December 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Solid Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : AOC 1086 is designed to deliver siRNA directly to the heart muscle to knock down specific disease-causing genetic mutations that cause rare genetic PLN cardiomyopathies.

                          Product Name : AOC 1086

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 12, 2024

                          Lead Product(s) : AOC 1086

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : The proceeds from the seed financing will support ongoing clinical development of TLT-101 for multiple serious forms of heart failure, with an initial focus on non-ischemic dilated cardiomyopathy.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : TLT-101

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          08

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : The proceeds will be used for Shift Bioscience’s AI cell simulation platform, for the identification of genes that can safely rejuvenate cells to combat the effects of age-related illnesses.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 15, 2024

                          Lead Product(s) : Gene-based Therapy

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : BGF

                          Deal Size : $16.0 million

                          Deal Type : Financing

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                          09

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : IsomAb collaborates with Pfizer Ignite to support preclinical development and IND-enabling studies for ISM-001 for the treatemnt of chronic limb threatening ischaemia.

                          Product Name : ISM-001

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 15, 2024

                          Lead Product(s) : ISM-001

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Pfizer Inc

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          10

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : The seed funding enabled clock.bio to generate its Atlas of Rejuvenation Factors across the entire human genome and identified several potential gene therapy targets for rejuvenation.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 09, 2024

                          Lead Product(s) : iPSC-based Cell Therapy

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : LocalGlobe

                          Deal Size : $5.3 million

                          Deal Type : Financing

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