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Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Gatehouse Bio \/ AstraZeneca","highestDevelopmentStatusID":"4","companyTruncated":"Gatehouse Bio \/ AstraZeneca"},{"orgOrder":0,"company":"Huadong Medicine","sponsor":"SynerK PharmaTech","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Collaboration","leadProduct":"SNK-2726","moa":"Angiotensin receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"Huadong Medicine","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Huadong Medicine \/ SynerK PharmaTech","highestDevelopmentStatusID":"4","companyTruncated":"Huadong Medicine \/ SynerK PharmaTech"},{"orgOrder":0,"company":"ZyVersa Therapeutics, Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"IC 100","moa":"NLRP3 inflammasome","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"ZyVersa Therapeutics, Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ZyVersa Therapeutics, Inc \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"ZyVersa Therapeutics, Inc \/ Inapplicable"},{"orgOrder":0,"company":"Poxel","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"FRANCE","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"R\u2010Pioglitazone","moa":"ACSL4\/MPC","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"Poxel","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Poxel \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Poxel \/ Inapplicable"}]

Find Drugs for Cardiology/Vascular Diseases in Preclinical Development

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : PXL065 (R‐Pioglitazone) inhibits mitochondrial pyruvate carrier and Acyl CoA Synthetase 4 thus acting on oxidative stress, inflammation and fibrosis, associated with hypertrophic cardiomyopathy.

                          Product Name : PXL065

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 20, 2025

                          Lead Product(s) : R‐Pioglitazone

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : MCC950 is a NLRP3-inflammasome inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of heart failure (HFpEF) and type 2 diabetes.

                          Product Name : IC 100

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : IC 100

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : The funding will be used to expand the pipeline by acquiring additional distressed assets and for advancement into early-stage clinical trials of Ignota's first asset, a PDE9A inhibitor.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 26, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Montage Ventures

                          Deal Size : $6.9 million

                          Deal Type : Financing

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                          04

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Nimbus, in collaboration with Eli Lilly, has achieved a milestone by targeting a specific isoform of AMP-activated protein kinase (AMPK) for the treatment of cardiometabolic diseases.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 25, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Eli Lilly

                          Deal Size : $496.0 million

                          Deal Type : Collaboration

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                          05

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Faun1083 is a potential first-in-class therapeutic targeting heart failure with preserved ejection fraction, a disease with currently limited treatment options.

                          Product Name : Faun1083

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 08, 2025

                          Lead Product(s) : Faun1083

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Through the collaboration, the two parties will jointly develop the small nucleic acid (siRNA) drug SNK-2726, which targets angiotensinogen (AGT) for the treatment of hypertension.

                          Product Name : SNK-2726

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          December 30, 2024

                          Lead Product(s) : SNK-2726

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : SynerK PharmaTech

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Under the agreement, Hansoh has granted Merck an exclusive global license to develop, manufacture and commercialize HS-10535, an investigational preclinical oral small molecule GLP-1 receptor agonist.

                          Product Name : HS-10535

                          Product Type : Small molecule

                          Upfront Cash : $112.0 million

                          December 18, 2024

                          Lead Product(s) : HS-10535

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Merck & Co

                          Deal Size : $2,012.0 million

                          Deal Type : Licensing Agreement

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                          08

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Solid to receive exclusive worldwide licenses to AAV-based Suppression-Replacement gene therapy platform and multiple next-generation cardiac gene therapy programs.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          December 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Solid Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : AOC 1086 is designed to deliver siRNA directly to the heart muscle to knock down specific disease-causing genetic mutations that cause rare genetic PLN cardiomyopathies.

                          Product Name : AOC 1086

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 12, 2024

                          Lead Product(s) : AOC 1086

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : The proceeds from the seed financing will support ongoing clinical development of TLT-101 for multiple serious forms of heart failure, with an initial focus on non-ischemic dilated cardiomyopathy.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : TLT-101

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Financing

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