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    [{"orgOrder":0,"company":"Carisma Therapeutics","sponsor":"Moderna Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Carisma Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Carisma Therapeutics \/ Moderna Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Carisma Therapeutics \/ Moderna Therapeutics"},{"orgOrder":0,"company":"Carisma Therapeutics","sponsor":"Moderna Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Carisma 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Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Carisma Therapeutics \/ Inapplicable"}]

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                            01

                            Carisma Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Discovery Platform

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Expanded Collaboration

                            DEALS_DEV arrow-down

                            Carisma and Moderna Expand Collaboration On in Vivo CAR-M Autoimmune Therapies

                            Details : Under this expanded collaboration,Carisma and Moderna will leverage Carisma's CAR-M technology and Moderna's mRNA/LNP platform to develop novel approaches for the treatment of autoimmune disease.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            October 09, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Discovery Platform

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Expanded Collaboration

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                            02

                            Carisma Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carisma Highlights Pre-Clinical Data On Anti-GPC3 CAR-M Therapy for Liver Cancer

                            Details : Anti-GPC3 in vivo chimeric antigen receptor macrophage and monocyte therapy being investigated for the treament of GPC3-positive hepatocellular carcinoma.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            August 11, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Carisma Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Carisma Therapeutics Nominates First CAR-M Candidate for Hepatocellular Carcinoma

                            Details : Carisma collaboration with Moderna announces the development candidate is an in vivo CAR-M targeting Glypican-3 and is designed to treat solid tumors, including hepatocellular carcinoma.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            June 27, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carisma Granted FDA Fast Track for CT-0525 in HER2-Overexpressing Solid Tumors

                            Details : CT-0525 is an ex vivo gene-modified autologous CAR-Monocyte cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2).

                            Product Name : CT-0525

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 25, 2024

                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carisma Doses First CT-0525 HER2 CAR-Monocyte Patient

                            Details : CT-0525 is an ex vivo gene-modified autologous CAR-monocyte cellular therapy, which is being evaluated for the treatment of patients with solid tumors that overexpress HER2.

                            Product Name : CT-0525

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            May 16, 2024

                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            First In Vivo CAR-M Lead Candidate Nominated Under Carisma-Moderna Collaboration

                            Details : The collaboration brings together Carisma's chimeric antigen receptor macrophage (CAR-M) platform with Moderna's messenger RNA (mRNA) and lipid nanoparticle (LNP) technologies to generate and develop in vivo CAR-M therapeutics for oncology.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            December 14, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Moderna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carisma Therapeutics Announces FDA Clearance of IND Application for CT-0525, a Novel HER2-Targeting CAR-Monocy...

                            Details : CT-0525 is an ex vivo gene-modified autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2).

                            Product Name : CT-0525

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 28, 2023

                            Lead Product(s) : CT-0525

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : CT-0508,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carisma Therapeutics Announces First Patient Dosed in Phase 1 Study of CT-0508 in Combination with KEYTRUDA (p...

                            Details : CT-0508 is a human epidermal growth factor receptor 2 (HER2) targeted chimeric antigen receptor macrophage (CAR-M). It is being evaluated in a landmark Phase 1 multi-center clinical trial that focuses on patients with recurrent or metastatic HER2-overexp...

                            Product Name : CT-0508

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 28, 2023

                            Lead Product(s) : CT-0508,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Carisma Therapeutics

                            U.S.A arrow
                            Interphex
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                            Carisma Therapeutics

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                            Lead Product(s) : Oportuzumab Monatox

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Sesen Bio

                            Deal Size : $30.0 million

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Sesen Bio and Carisma Therapeutics Announce Substantial Increase to Expected Special Cash Dividend in Connecti...

                            Details : Vicineum (oportuzumab monatox) is an investigational locally administered recombinant fusion protein that targets epithelial cell adhesion molecule antigens on the surface of tumor cells to deliver Pseudomonas Exotoxin A.

                            Product Name : Vicineum

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            December 29, 2022

                            Lead Product(s) : Oportuzumab Monatox

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Sesen Bio

                            Deal Size : $30.0 million

                            Deal Type : Merger

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                            10

                            Carisma Therapeutics

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                            Carisma Therapeutics

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                            Lead Product(s) : CT-0508

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Novartis Signs Initial Agreement With Carisma Therapeutics For The Manufacturing of HER 2 Targeted CAR-M Cell ...

                            Details : Under the terms of agreement, the Carisma manufacturing process will be transferred to Novartis Cell Therapy Site in Morris Plains, U.S for manufacturing of the HER 2 targeted CAR-M cell therapy, which is tested in initial trials for the treatment of sol...

                            Product Name : CT-0508

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 03, 2022

                            Lead Product(s) : CT-0508

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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