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Morgan","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2023","type":"Public Offering","leadProduct":"CT-388","moa":"","graph1":"Endocrinology","graph2":"Phase I\/ Phase II","graph3":"Carmot Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Carmot Therapeutics \/ J.P. Morgan","highestDevelopmentStatusID":"7","companyTruncated":"Carmot Therapeutics \/ J.P. Morgan"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"F. 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Hoffmann-La Roche","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2024","type":"Acquisition","leadProduct":"CT-388","moa":"","graph1":"Endocrinology","graph2":"Phase I\/ Phase II","graph3":"Carmot Therapeutics","amount2":3.1000000000000001,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Endocrinology","amount2New":3.1000000000000001,"dosageForm":"Injection","sponsorNew":"Carmot Therapeutics \/ F. Hoffmann-La Roche","highestDevelopmentStatusID":"7","companyTruncated":"Carmot Therapeutics \/ F. Hoffmann-La Roche"}]

Find Clinical Drug Pipeline Developments & Deals by Carmot Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Roche will enhance its portfolio with Carmot’s GLP-1/GIP receptor agonists, including CT-388, CT-996, and CT-868, for metabolic diseases like obesity and diabetes.

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : $2,700.0 million

                          January 29, 2024

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : $3,100.0 million

                          Deal Type : Acquisition

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Through the acquisition, Roche will build its portfolio by adding Carmot’s pipeline of GLP-1/GIP receptor agonist, including CT-388, CT-996 and CT-868 which are being evaluated for the treatment of metabolic diseases including obesity and diabetes.

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : $2,700.0 million

                          December 04, 2023

                          Lead Product(s) : CT-388

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : $3,100.0 million

                          Deal Type : Acquisition

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The net proceeds will be used to advance the clinical development of CT-388, a novel once-weekly dual GLP-1 and GIP receptor modulator, for the treatment of type-2 diabetes and obesity.

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          November 17, 2023

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : J.P. Morgan

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CT-868 is a once-daily subcutaneous injectable, dual GLP-1/GIP receptor agonist being developed as an adjunct to insulin for the treatment of people with type 1 diabetes (T1D) with overweight or obesity.

                          Brand Name : CT-868

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          November 15, 2023

                          Lead Product(s) : CT-868

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CT-996 is a once-daily oral, small molecule GLP-1 receptor agonist being developed for the treatment of obesity and type 2 diabetes (T2D). it was designed to exhibit signaling bias on the GLP-1 receptor, resulting in activation of cAMP.

                          Brand Name : CT-996

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 10, 2023

                          Lead Product(s) : CT-996

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The proceeds will be used to strengthen Carmot's portfolio of clinical and preclinical assets designed to modulate gut hormones that are central to energy homeostasis, including CT-388, a dual GLP-1/GIP receptor modulator for obese adults with and withou...

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          May 25, 2023

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : Deep Track Capital

                          Deal Size : $150.0 million

                          Deal Type : Series E Financing

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The spin-off enables Carmot to focus on clinical-stage candidates CT-388 and CT-868 (dual GLP-1/GIP receptor modulators), additional IND-stage programs including CT-996 (an oral, small molecule GLP-1 receptor agonist) and a long-acting PYY analogue.

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          January 05, 2023

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Recipient : Kimia Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Demerger

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The funding will support the phase 2 studies for CT-388, a dual modulator of the GLP-1 and GIP incretin receptors, phase 1 studies for CT-996, an oral small molecule GLP-1 receptor agonist, and phase 2 studies for CT-868, a first-inclass fully biased GLP...

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          July 26, 2022

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : The Column Group

                          Deal Size : $160.0 million

                          Deal Type : Series D Financing

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : FDA recently approved LUMAKRAS for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, who have received at least one prior systemic therapy.

                          Brand Name : Lumakras

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 29, 2021

                          Lead Product(s) : Sotorasib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Amgen Inc

                          Deal Size : $240.0 million

                          Deal Type : Collaboration

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CT-388 is a fully biased dual GLP-1 and GIP receptor modulator with a unique pharmacological profile optimized for improved tolerability at the GLP-1 receptor, anticipated to be dosed once-weekly.

                          Brand Name : CT-388

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          June 24, 2021

                          Lead Product(s) : CT-388

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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