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    [{"orgOrder":0,"company":"Cartesian Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"Descartes 30","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase I\/ Phase II","graph3":"Cartesian Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Cartesian Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Cartesian Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cartesian Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Not Applicable","leadProduct":"Descartes-11","moa":"","graph1":"Oncology","graph2":"Phase 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                            01

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Receives RPD Designation for Descartes-08 in Juvenile Dermatomyositis

                            Details : Descartes-08 is a potential first-in-class mRNA CAR-T product candidate targeting B-cell maturation antigen (BCMA). It is under investigation for Juvenile Dermatomyositis.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 09, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-15

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Doses First Patient in Phase 1 Trial of Descartes-15 mRNA CAR-T Therapy

                            Details : Descartes-15 is the next-generation autologous anti-BCMA mRNA-engineered mRNA CAR-T cell therapy. It is being investigated for Relapsed/Refractory Multiple Myeloma.

                            Brand Name : Descartes-15

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 03, 2024

                            Lead Product(s) : Descartes-15

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Cartesian Therapeutics Announces $130 Million Private Placement Equity Financing

                            Details : The Company intends to use the net proceeds from the financing to fund its pipeline, which includes Descartes-08, a potential first-in-class mRNA CAR-T for patients with generalized myasthenia gravis.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            July 02, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

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                            04

                            Cartesian Therapeutics

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                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Therapeutics Doses First Patient in Phase 2 Trial of Descartes-08 for Lupus

                            Details : Descartes-08, lead mRNA cell therapy candidate and a potential first-in-class mRNA CAR-T product candidate targeting B-cell maturation antigen (BCMA). It is under investigation for SLE.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 02, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Cartesian Therapeutics

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                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Reports Positive Phase 2b Results for Descartes-08 in Myasthenia Gravis

                            Details : Descartes-08, lead mRNA cell therapy candidate and a potential first-in-class mRNA CAR-T product candidate targeting B-cell maturation antigen (BCMA). It is under investigation for Myasthenia Gravis.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 02, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Therapeutics Receives RMAT Designation for Descartes-08 in Myasthenia Gravis

                            Details : Descartes-08, the Company’s lead product candidate, is an autologous mRNA CAR-T directed against the B cell maturation antigen initially being developed for the treatment of MG.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 22, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Cartesian Therapeutics

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                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Announces Positive Long-Term Data from Phase 2A Study of Descartes-08 Therapy

                            Details : Descartes-08 is a potential first-in-class mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T). It is under phase 2 clinical development for generalized myasthenia gravis.

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            January 08, 2024

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Recipient : Selecta Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Selecta Biosciences Announces Merger with Cartesian Therapeutics

                            Details : The net proceeds will support the development of the Cartesian pipeline through the Phase 3 study of lead product candidate, Descartes-08, a potential first-in-class RNA-engineered chimeric antigen receptor T-cell therapy (rCAR-T) for the treatment of my...

                            Brand Name : Descartes-08

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            November 13, 2023

                            Lead Product(s) : Descartes-08

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Recipient : Selecta Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            09

                            Cartesian Therapeutics

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                            Cartesian Therapeutics

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                            Lead Product(s) : RNA Engineered Allogeneic Human Mesenchymal Stem Cells

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : National Institutes of Health

                            Deal Size : $2.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Cartesian Therapeutics Wins Fourth NIH Grant for Clinical Trials of RNA Cell Therapies

                            Details : This $2 million competitive R&D award from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) will support Cartesian's clinical development for Descartes-30, the first RNA cell therapy for respiratory disease...

                            Brand Name : Descartes-30

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            May 04, 2021

                            Lead Product(s) : RNA Engineered Allogeneic Human Mesenchymal Stem Cells

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : National Institutes of Health

                            Deal Size : $2.0 million

                            Deal Type : Funding

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                            10

                            Cartesian Therapeutics

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                            Lead Product(s) : Descartes-11

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cartesian Therapeutics Initiates Phase 2 Clinical Trial of First RNA-Engineered Cell Therapy for Frontline Can...

                            Details : Descartes-11 is engineered with Cartesian’s RNA Armory℠ platform to express its CAR molecules transiently instead of permanently, thereby reducing both short-term and long-term risks inherent with conventional CAR T-cell therapies.

                            Brand Name : Descartes-11

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 22, 2021

                            Lead Product(s) : Descartes-11

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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