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    [{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Vertex Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Agreement","leadProduct":"CB 2782-PEG","moa":"C3 receptor","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Catalyst Biosciences \/ Vertex Pharmaceuticals","highestDevelopmentStatusID":"4","companyTruncated":"Catalyst Biosciences \/ Vertex Pharmaceuticals"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"GC Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2023","type":"Acquisition","leadProduct":"Marzeptacog Alpha","moa":"Factor VIII","graph1":"Genetic Disease","graph2":"Phase 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Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"CB 4332","moa":"Undisclosed","graph1":"Immunology","graph2":"Preclinical","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Undisclosed","year":"2020","type":"Inapplicable","leadProduct":"CB 2679d-GT","moa":"Factor IX","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"Marzeptacog Alpha","moa":"Factor VIII","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst 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Disease","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Marzeptacog Alpha","moa":"Factor VIII","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Dalcinonacog Alpha","moa":"Factor IX","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Marzeptacog Alpha","moa":"Factor VIII","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Catalyst Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Catalyst Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"Marzeptacog Alpha","moa":"Factor VIII","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Catalyst Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Catalyst Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Catalyst Biosciences \/ Inapplicable"}]

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                            01

                            Catalyst Biosciences

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                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : GC Biopharma

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            GC Biopharma Signs Agreement with Catalyst Biosciences for the Acquisition of Rare Disease Pipeline in Hematol...

                            Details : The agreement will bring to GC Biopharma 3 programs, including MarzAA (marzeptacog alfa), an engineered factor VIIa which is ready for Phase 3 clinical stage development.

                            Product Name : MarzAA

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            February 27, 2023

                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : GC Biopharma

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            02

                            Catalyst Biosciences

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                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Vertex Pharmaceuticals

                            Deal Size : $60.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Catalyst Biosciences Sells Complement Portfolio for $60 Million

                            Details : Companies have signed agreement under which Vertex has acquired Catalyst’s portfolio of protease medicines that regulate complement, including CB 2782-PEG.

                            Product Name : CB 2782-PEG

                            Product Type : Other Small Molecule

                            Upfront Cash : $60.0 million

                            May 23, 2022

                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Vertex Pharmaceuticals

                            Deal Size : $60.0 million

                            Deal Type : Agreement

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                            03

                            Catalyst Biosciences

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                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Biogen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Catalyst Biosciences Regains Rights to CB 2782-PEG for the Treatment of Dry AMD Expands CBIO's Complement Port...

                            Details : Under the terms of the agreement, Biogen has returned the rights for further development on CB 2782-PEG and has ended the collaboration on other potential AMD treatments.

                            Product Name : CB 2782-PEG

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 15, 2022

                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Biogen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Catalyst Biosciences

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                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Biogen

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Catalyst Biosciences Expands its Protease Medicines Patent Portfolio of Complement Factor 3 Degraders

                            Details : The patent protects nucleic acids encoding modified proteases that selectively cleave and degrade complement factor 3 (C3), including the lead candidate CB 2782-PEG, Catalyst's potential best-in-class treatment for dry AMD, currently licensed to Biogen.

                            Product Name : CB 2782-PEG

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 04, 2021

                            Lead Product(s) : CB 2782-PEG

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Biogen

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Catalyst Biosciences

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                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Hematology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Grants Catalyst Biosciences Orphan Drug Designation for MarzAA for the Treatment of Factor VII Deficiency

                            Details : Marzeptacog alfa (activated), or MarzAA demonstrates its potential in treating multiple rare bleeding disorders. MarzAA, a subcutaneously (SQ) administered next-generation engineered coagulation Factor VIIa (FVIIa) for the treatment of episodic bleeding.

                            Product Name : MarzAA

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            September 28, 2021

                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Hematology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Catalyst Biosciences

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                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Catalyst Biosciences Presents Four Posters at the International Society for Thrombosis and Haemostasis (ISTH) ...

                            Details : The objective of the study was to conduct simulations using a MarzAA-specific, population pharmacokinetic (PK) model in a large population following different dose levels of MarzAA.

                            Product Name : MarzAA

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            July 19, 2021

                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Catalyst Biosciences

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                            Catalyst Biosciences

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                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Catalyst Biosciences Receives FDA Fast Track Designation for Subcutaneous MarzAA for Episodic Bleeding in Fact...

                            Details : This trial is being conducted in parallel with the ongoing Phase 3 registration trial evaluating MarzAA for the treatment of episodic bleeds in patients with Hemophilia A or B with inhibitors.

                            Product Name : MarzAA

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            June 28, 2021

                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Catalyst Biosciences

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                            Catalyst Biosciences

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                            Lead Product(s) : CB 4332

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Catalyst Biosciences to Host Research and Development Day on CB 4332 and Complement Programs

                            Details : The natural history of disease study will follow up and assess these patients for clinical outcomes, biomarkers of complement dysregulation as well as safety and effectiveness of their current treatments in preparation for the clinical development progra...

                            Product Name : CB 4332

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 07, 2021

                            Lead Product(s) : CB 4332

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Catalyst Biosciences

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                            Catalyst Biosciences

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                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Catalyst Biosciences Completes MarzAA Pharmacokinetic & Pharmacodynamic Study

                            Details : The results support the use of SQ MarzAA to treat episodic bleeding. Company to enroll the first patient in its Phase 3 registration trial evaluating the efficacy of SQ MarzAA to treat bleeding events in individuals with hemophilia A or B with inhibitors...

                            Product Name : MarzAA

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            October 06, 2020

                            Lead Product(s) : Marzeptacog Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Catalyst Biosciences

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                            Lead Product(s) : CB 2679d-GT

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Early Data Support Catalyst Biosciences’ Potential Hemophilia B Gene Therapy

                            Details : The new data include a direct comparison between CB 2679d-GT and the Padua variant in a mouse model of hemophilia B.

                            Product Name : CB 2679d-GT

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            August 07, 2020

                            Lead Product(s) : CB 2679d-GT

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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