Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : National Cancer Institute
Deal Size : Inapplicable
Deal Type : Inapplicable
Taiho Oncology Announces Decitabine and Cedazuridine in NIH Trials
Details : Inqovi is a combination of decitabine, a nucleoside metabolic inhibitor and cedazuridine, a cytidine deaminase inhibitor. It is being evaluated for IDH2-Mutated Myelodysplastic Syndrome.
Product Name : Inqovi
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
January 14, 2025
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : National Cancer Institute
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
Venetoclax Plus HMA Therapy Shows Encouraging Results in Higher-Risk MDS/CMML
Details : Inqovi is a combination of decitabine and cedazuridine, evaluated in combination with venetoclax for treating higher-risk myelodysplastic syndromes and chronic myelomonocytic leukemia.
Product Name : Inqovi
Product Type : Small molecule
Upfront Cash : Not Applicable
February 22, 2024
Lead Product(s) : Decitabine,Cedazuridine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Study Phase : Approved FDF
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Inaqovi (decitabine and cedazuridine) is an orally administered, fixed-dose combination and inhibitor of cytidine deaminase, which is indicated for newly diagnosed acute myeloid leukaemia.
Product Name : Inaqovi
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
September 19, 2023
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ASTX727 is an orally administered, fixed dose combination of the approved anti-cancer DNA hypomethylating agent, decitabine, together with cedazuridine, an inhibitor of cytidine deaminase.
Product Name : ASTX727
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
August 22, 2022
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ASCERTAIN - AML clinical study of decitabine and cedazuridine, as a fixed-dose combination (ASTX727), in adult patients with AML not candidates for chemotherapy demonstrated decitabine exposure equivalence of total 5-day dosing between oral ASTX727 and i...
Product Name : ASTX727
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
May 12, 2022
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Orphan Drug Designation from EC was received on the basis of Phase1 and Phase 2 clinical trial results, for the combination of decitabine and ASTX727 (cedazuridine) for the treatment of Acute Myeloid Leukemia.
Product Name : ASTX727
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
January 06, 2022
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Inqovi is oral fixed-dose combination of anti-cancer Deoxyribonucleic acid hypomethylating agent, decitabine, and cytidine deaminase inhibitor, cedazuridine. Updated efficacy data demonstrated overall response rate of 62%, with 22% of patients achieving ...
Product Name : Inqovi
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
September 23, 2021
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Astex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Recro Enters Development Agreement With Astex Pharmaceuticals
Details : ASTX727 is a small molecule DNMT inhibitor currently under Phase III trial. Astex and Recro expand partnership for oral solid dose drug product services.
Product Name : ASTX727
Product Type : Cytotoxic Drug
Upfront Cash : Undisclosed
May 18, 2021
Lead Product(s) : Decitabine,Cedazuridine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Astex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Study Phase : Approved FDF
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : FDA approved hypomethylating agent INQOVI® (decitabine and cedazuridine) 35 mg/100 mg tablets, for oral use, has been included in the latest National Comprehensive Cancer Network® Clinical Practice Guidelines in Oncology for Myelodysplastic Syndromes.
Product Name : Inqovi
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
November 23, 2020
Lead Product(s) : Cedazuridine,Decitabine
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Sponsor : Astex Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Decitabine,Cedazuridine,Undisclosed
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Astex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The initial focus will be on evaluating Astex’s oral decitabine and cedazuridine hypomethylating agent (INQOVI®) in combinations with other therapies. MD Anderson and Astex will design new clinical studies to be conducted at MD Anderson.
Product Name : INQOVI
Product Type : Small molecule
Upfront Cash : Undisclosed
September 08, 2020
Lead Product(s) : Decitabine,Cedazuridine,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Astex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration