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molecule","year":"2023","type":"Partnership","leadProduct":"CT-G20","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Celltrion","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Celltrion \/ Celltrion","highestDevelopmentStatusID":"6","companyTruncated":"Celltrion \/ Celltrion"},{"orgOrder":0,"company":"Celltrion","sponsor":"Hasten Biopharmaceutic","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"SOUTH KOREA","productType":"Small molecule","year":"2024","type":"Acquisition","leadProduct":"Azilsartan","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved","graph3":"Celltrion","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Celltrion \/ Hasten 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Find Clinical Drug Pipeline Developments & Deals by Celltrion

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Steqeyma (ustekinumab), a biosimilar to Stelara is an approved IL-12/IL-23 inhibitor indicated for the treatment of moderate to severe plaque psoriasis in patients with 6 years or older.

                          Brand Name : Steqeyma

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 25, 2024

                          Lead Product(s) : Ustekinumab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Steqeyma (ustekinumab), is an approved IL-12/IL-23 inhibitor is given once in 12 weeks SC and IV for the treatment of moderate to severe plaque psoriasis in patients with 6 years or older.

                          Brand Name : Steqeyma

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 01, 2024

                          Lead Product(s) : Ustekinumab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Through the acquisition, Hasten will own the Marketing Authorisation Holder rights of products in 8 countries, which includes Edarbi (azilsartan medoxomil) indicated for the treatment of hypertension.

                          Brand Name : Edarbi

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 02, 2024

                          Lead Product(s) : Azilsartan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Hasten Biopharmaceutic

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Through this acquisition, Hasten leverages commercial rights to treatments for various chronic disease, which include the approved product Edarbi (azilsartan medoxomil), indicated for hypertension.

                          Brand Name : Edarbi

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 28, 2024

                          Lead Product(s) : Azilsartan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Hasten Biopharmaceutic

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Omlyclo (omalizumab) is an antibody inhibiting IgE binding. It is approved to treat chronic spontaneous urticaria & moderate to severe persistent asthma.

                          Brand Name : Omlyclo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 23, 2024

                          Lead Product(s) : Omalizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Zymfentra (infliximab) a TNF alpha inhibitor, is the first and only FDA-approved SC formulation, for adults with moderately to severely active ulcerative colitis and crohn’s disease.

                          Brand Name : Zymfentra

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 21, 2024

                          Lead Product(s) : Infliximab

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CT-P39 (omalizumab), a biosimilar to XOLAIR®, inhibits IgE binding to high-affinity IgE receptors on mast cells and basophils, and is being developed to treat chronic spontaneous urticaria.

                          Brand Name : CT-P39

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          March 10, 2024

                          Lead Product(s) : Omalizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Remsima (infliximab) blocks the action of TNF-alpha. It is approved for maintenance therapy in adults with moderately to severely active ulcerative colitis and crohn’s disease.

                          Brand Name : Remsima

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 18, 2024

                          Lead Product(s) : Infliximab

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CT-P47 (tocilizumab-biosimilar) is a recombinant humanized monoclonal antibody acting as an IL-6 receptor inhibitor, currently evaluated for moderate to severe active rheumatoid arthritis.

                          Brand Name : CT-P47

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 28, 2024

                          Lead Product(s) : Tocilizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Zymfentra is the first and only FDA-approved subcutaneous (SC) formulation of infliximab approved for the maintenance treatment of adult patients with moderately to severely active ulcerative colitis and Crohn’s disease.

                          Brand Name : Zymfentra

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 21, 2023

                          Lead Product(s) : Infliximab-dyyb

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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