Lead Product(s) : CEND-1,Atezolizumab,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Under the terms of the agreement, Roche will be responsible for operational management of the trial while Cend and Roche share equally in the costs of the CEND-1 treatment arms in the study.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Undisclosed
August 10, 2022
Lead Product(s) : CEND-1,Atezolizumab,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : CEND-1,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Peer-reviewed study data suggest CEND-1, in combination with gemcitabine and nab-paclitaxel, demonstrates favorable safety and tolerability along with encouraging efficacy.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Not Applicable
July 06, 2022
Lead Product(s) : CEND-1,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CEND-1,Oxaliplatin,Calcium Folinate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Lisata Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CEND-1 is an investigational drug that modifies the tumor microenvironment. It is targeted to tumor vasculature by its affinity for alpha-v integrins that are selectively expressed in tumor, but not healthy tissue vasculature.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Not Applicable
June 09, 2022
Lead Product(s) : CEND-1,Oxaliplatin,Calcium Folinate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Lisata Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CEND-1,Oxaliplatin,Calcium Folinate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Lisata Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CEND-1 is a cyclic peptide that, once bound to these integrins, is cleaved by proteases expressed in tumors to release a peptide fragment, called a CendR fragment, which binds to a second receptor, called neuropilin-1, to activate a novel uptake pathway.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Not Applicable
May 26, 2022
Lead Product(s) : CEND-1,Oxaliplatin,Calcium Folinate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Lisata Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CEND-1,Paclitaxel,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cend Therapeutics’ CEND-1 Granted Fast Track Designation for Pancreatic Cancer
Details : Cend will also explore applications of CEND-1 in combination with additional agents, including immunotherapies for mPDAC, and plans to expand development into additional solid tumor cancer indications.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Not Applicable
June 29, 2021
Lead Product(s) : CEND-1,Paclitaxel,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CEND-1,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Cend Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Cend presented favorable clinical results at the European Society for Molecular Oncology (ESMO) meeting September 2020 and is advancing into Phase 2 clinical trials in pancreatic cancer with CEND-1 in combination with gemcitabine and nab-paclitaxel.
Brand Name : CEND-1
Molecule Type : Peptide
Upfront Cash : Undisclosed
February 16, 2021
Lead Product(s) : CEND-1,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Cend Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
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