[{"orgOrder":0,"company":"CervoMed","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Diffusion Pharmaceuticals Evaluating TSC Against Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Patients","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Undisclosed","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"April 2020","year":"2020","type":"Not Applicable","leadProduct":"Trans Sodium Crocetinate","moa":"","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase I","graph3":"CervoMed","amount2":0,"therapeuticAreaNew":"Infections and Infectious Diseases","highestDevelopmentStatusNew":"Phase I","highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","productSubType":"","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"CervoMed \/ Not 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                          01

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : VX-745 (neflamapimod), an investigational orally administered small molecule brain penetrant that inhibits p38MAP kinase alpha. It is being evaluated for the treatment of dementia with lewy bodies.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 11, 2024

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : The Company intends to use the net proceeds to fund research and development of its clinical-stage product candidate, VX-745 (neflamapimod), an investigational orally administered small molecule brain penetrant that inhibits p38MAP kinase alpha.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : $50.0 million

                          March 28, 2024

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : RA Capital Management

                          Deal Size : $149.4 million

                          Deal Type : Private Placement

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                          03

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : The Combined company will pursue late-stage clinical development of oral VX-745 (neflamapimod), a small molecule brain penetrant that inhibits p38MAP kinase alpha (p38a), for the treatment of dementia with Lewy bodies.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 16, 2023

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : EIP Pharma

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          04

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : VX-745 (neflamapimod) is an investigational drug that is an orally administered small molecule brain penetrant that inhibits p38MAP kinase alpha, which is investigated for the treatment of dementia with lewy bodies.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 14, 2023

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : The Combined company will pursue late-stage clinical development of oral neflamapimod, a small molecule brain penetrant that inhibits p38MAP kinase alpha (p38a), for the treatment of dementia with Lewy bodies.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 30, 2023

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Recipient : CervoMed

                          Deal Size : $19.0 million

                          Deal Type : Merger

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                          06

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : VX-745 (neflamapimod) is an investigational oral, brain-penetrating small molecule drug. The combined pre-clinical and clinical data are consistent with neflamapimod treating the underlying disease process and having the potential to be the first disease...

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 02, 2022

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : Trans sodium crocetinate (TSC), is being developed to enhance the diffusion of oxygen to tissues with low oxygen levels, also known as hypoxia, a serious complication of many of medicine’s most intractable and difficult-to-treat conditions.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 25, 2022

                          Lead Product(s) : Trans Sodium Crocetinate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : Neflamapimod (VX-745) is an investigational oral, brain-penetrating small molecule drug that inhibits the intra-cellular enzyme p38MAP kinase alpha (p38α which is expressed in neurons under conditions of stress and disease.

                          Brand Name : VX-745

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 21, 2022

                          Lead Product(s) : Neflamapimod

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : Diffusion aligns with FDA on design of an open-label, dose-escalation, Phase 2 safety and efficacy study of trans sodium crocetinate (“TSC”) in newly diagnosed glioblastoma multiforme (“GBM”) patients.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 26, 2022

                          Lead Product(s) : Trans Sodium Crocetinate,Temozolomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Discovery on Target
                          Not Confirmed
                          Discovery on Target
                          Not Confirmed

                          Details : Positive effects for Trans Sodium Crocetinate on post-exercise recovery based when comparing measurements 10 min post-exercise to measurements at the end of the exercise interval.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 23, 2022

                          Lead Product(s) : Trans Sodium Crocetinate

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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