Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition
Jazz Pharmaceuticals to Acquire Chimerix, Further Diversifying Oncology Portfolio
Details : Through the acquisition, Jazz will strengthen it's oncology pipeline, which includes ONC201 (dordaviprone). It is being in the evaluated late-stage for the treatment of H3 K27M-mutant diffuse glioma.
Product Name : ONC201
Product Type : Other Small Molecule
Upfront Cash : $935.0 million
March 05, 2025
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix Announces FDA Acceptance and Priority Review of NDA for Dordaviprone
Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.
Product Name : ONC201
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 18, 2025
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix Submits Dordaviprone NDA for Accelerated Approval Of Recurrent Diffuse Glioma
Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.
Product Name : ONC201
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 30, 2024
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix to Submit Dordaviprone for Accelerated Approval in for H3 K27M-Mutant Glioma
Details : ONC201 (dordaviprone) targets the targets the mitochondrial protease ClpP and dopamine receptor D2. It is being evaluated for the treatment of recurrent H3 K27M-mutant diffuse glioma.
Product Name : ONC201
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 09, 2024
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved FDF
Sponsor : BARDA
Deal Size : $374.5 million
Deal Type : Agreement
Chimerix Awarded BARDA Contract for TEMBEXA as Medical Countermeasure for Smallpox
Details : Collaboration with BARDA for the development of TEMBEXA (brincidofovir) has provided the United States government with a second therapeutic option to ensure the federal government’s readiness for a potential smallpox emergency.
Product Name : Tembexa
Product Type : Other Small Molecule
Upfront Cash : $238.0 million
August 29, 2022
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved FDF
Sponsor : BARDA
Deal Size : $374.5 million
Deal Type : Agreement
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ONC201 is a new drug candidate that kills cancer cells but not normal cells in laboratory studies and has been previously evaluated in a phase I clinical trial in advanced cancer patients.
Product Name : ONC201
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 12, 2022
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved FDF
Sponsor : Public Health Agency of Canada
Deal Size : $25.3 million
Deal Type : Agreement
Details : Chimerix signed a contract agreement to procure TEMBEXA® (brincidofovir). Execution of this contract will be the responsibility of Chimerix, as it is expected to substantially occur prior to the close of the pending transaction with Emergent BioSolution...
Product Name : Tembexa
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 24, 2022
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved FDF
Sponsor : Public Health Agency of Canada
Deal Size : $25.3 million
Deal Type : Agreement
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved FDF
Sponsor : Emergent BioSolutions
Deal Size : $9.3 million
Deal Type : Agreement
Chimerix Announces $9.3 Million International TEMBEXA Procurement Agreement
Details : Chimerix expects to promptly provide treatment courses of TEMBEXA (brincidofovir) equivalent to the total value of the procurement contract. Execution of this contract will be the responsibility of Chimerix.
Product Name : Tembexa
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 23, 2022
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved FDF
Sponsor : Emergent BioSolutions
Deal Size : $9.3 million
Deal Type : Agreement
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved FDF
Sponsor : Emergent BioSolutions
Deal Size : $325.0 million
Deal Type : Acquisition
Details : TEMBEXA (brincidofovir), is an oral antiviral formulated as 100 mg tablets and 10 mg/mL oral suspension dosed once weekly for two weeks. TEMBEXA is indicated for the treatment of human smallpox disease in adult and pediatric patients, including neonates.
Product Name : Tembexa
Product Type : Other Small Molecule
Upfront Cash : $225.0 million
May 16, 2022
Lead Product(s) : Brincidofovir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved FDF
Sponsor : Emergent BioSolutions
Deal Size : $325.0 million
Deal Type : Acquisition
Lead Product(s) : Dociparstat Sodium
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The primary endpoint of the study is survival without the need for mechanical ventilation through day 28. The first cohort enrolled 12 patients randomized 1:1. One patient on DSTAT was ventilated and recovered.
Product Name : DSTAT
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 25, 2021
Lead Product(s) : Dociparstat Sodium
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable