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    [{"orgOrder":0,"company":"City of Hope","sponsor":"Chimeric","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2020","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"City of Hope \/ Chimeric","highestDevelopmentStatusID":"6","companyTruncated":"City of Hope \/ Chimeric"},{"orgOrder":0,"company":"City of Hope","sponsor":"Calidi Biotherapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2021","type":"Collaboration","leadProduct":"Allogeneic Neural Stem Cell","moa":"||Undisclosed","graph1":"Oncology","graph2":"IND Enabling","graph3":"City of 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Diseases","country":"U.S.A","productType":"Vaccine","year":"2023","type":"Licensing Agreement","leadProduct":"Triplex","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"City of Hope \/ Helocyte","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Helocyte"},{"orgOrder":0,"company":"City of Hope","sponsor":"Race Oncology Limited","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Licensing Agreement","leadProduct":"Bisantrene","moa":"FTO protein","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"City of Hope \/ Race Oncology Limited","highestDevelopmentStatusID":"9","companyTruncated":"City of Hope \/ Race Oncology Limited"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Controlled Substance","year":"2024","type":"Inapplicable","leadProduct":"Cannabidiol","moa":"CB1\/2 receptor","graph1":"Oncology","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"The Division of Cancer Treatment and Diagnosis","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2021","type":"Inapplicable","leadProduct":"CF33-hNIS-antiPDL1","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"City of Hope \/ The Division of Cancer Treatment and Diagnosis","highestDevelopmentStatusID":"6","companyTruncated":"City of Hope \/ The Division of Cancer Treatment and Diagnosis"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"White Button Mushroom Extract","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Inapplicable","leadProduct":"COH04S1","moa":"SARS-CoV-2-viral spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Atezolizumab","moa":"||CD3\/20","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Teclistamab","moa":"BCMA\/CD3","graph1":"Oncology","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Griffith University","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"ZPAMt","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"City of Hope \/ Griffith University","highestDevelopmentStatusID":"4","companyTruncated":"City of Hope \/ Griffith University"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Sotorasib","moa":"KRAS G12C","graph1":"Oncology","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2024","type":"Inapplicable","leadProduct":"DNA Vaccine","moa":"Amyloid-beta protein","graph1":"Oncology","graph2":"Phase I","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"City of Hope \/ Inapplicable"},{"orgOrder":0,"company":"City of Hope","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"COH04S1","moa":"SARS-CoV-2-viral spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"City of Hope","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"City of Hope \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"City of Hope \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by City of Hope

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                            01

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            Lead Product(s) : Cannabidiol

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope, BRC Start Clinical Trial for Cannabinoid in Breast Cancer

                            Details : BRC-001 is a first-in-class cannabinoid therapeutic, which is being investigating in a clinical trial as a supportive care in breast cancer.

                            Product Name : BRC-001

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            December 09, 2024

                            Lead Product(s) : Cannabidiol

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : DNA Vaccine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope Reports Phase 1 Success of Personalized Vaccine for Lymphoma

                            Details : The vaccine uses patient-specific biologic components called tumor neoantigens that can help the body mount an immune response to a particular tumor type to treat lymphoplasmacytic lymphoma.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            September 19, 2024

                            Lead Product(s) : DNA Vaccine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : Triplex

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Helocyte

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Fortress Biotech Subsidiary Helocyte Announces Option Agreement with City of Hope for Exclusive Worldwide Righ...

                            Details : Under the agreement, Helocyte gains patent rights to use CMV-MVA Triplex, a cytomegalovirus vaccine, in combination with cytomegalovirus-specific, Anti-HIV CAR T Cells for the treatment of adults living with HIV.

                            Product Name : CMV Vaccine

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            October 16, 2023

                            Lead Product(s) : Triplex

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Helocyte

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            04

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : Bisantrene

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Race Oncology Limited

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Race Executes Global License Agreement with City of Hope to Access FTO IP

                            Details : Under the agreement, Race will exclusively secure rights to a City of Hope patent application and associated know-how identifying that bisantrene may be the most potent inhibitor of the Fatso/Fat mass and obesity associated (FTO) protein.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            October 07, 2023

                            Lead Product(s) : Bisantrene

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Race Oncology Limited

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            05

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : Sotorasib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope Researchers Help Find Improved Treatment Options for Patients With Advanced Colorectal Cancer

                            Details : The Lancet Oncology study is a proof of principle that targeting KRAS G12C with a small molecule KRAS G12C inhibitor, sotorasib, can lead to tumor shrinkage and meaningful duration of disease control in a patient population that otherwise has very limite...

                            Product Name : Lumakras

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 14, 2021

                            Lead Product(s) : Sotorasib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : CF33-hNIS-antiPDL1

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope Opens Oncolytic Virus Clinical Trial for Breast Cancer Patients

                            Details : CF33-hNIS-antiPDL1, is genetically engineered from a naturally occurring virus is designed to infect, replicate in and kill cancer cells while sparing healthy cells

                            Product Name : CF33-hNIS-antiPDL1

                            Product Type : Other Large Molecule

                            Upfront Cash : Inapplicable

                            November 18, 2021

                            Lead Product(s) : CF33-hNIS-antiPDL1

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : Mosunetuzumab,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pivotal Study Led by City of Hope Shows First-in-Class Cancer Immunotherapy Achieves High Rate of Remission in...

                            Details : Mosunetuzumab, First-in-Class therapy, showing deep and durable responses for patients whose lymphoma has relapsed or is no longer responding to currently available therapies.

                            Product Name : BTCT4465A

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            November 12, 2021

                            Lead Product(s) : Mosunetuzumab,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            City of Hope

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed

                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : ZPAMt

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Griffith University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope and Griffith University Researchers Use Novel Method to Block HIV in Mice

                            Details : Scientists developed an anti-HIV protein called ZPAMt that can be delivered to affected areas using exosomes, nanosized parts of cells able to reach difficult-to-access areas of the body, such as the brain.

                            Product Name : ZPAMt

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            September 20, 2021

                            Lead Product(s) : ZPAMt

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Griffith University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            City of Hope

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed

                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : COH04S1

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            City of Hope Trial Tests a New COVID-19 Vaccine in Immunocompromised Bone Marrow Transplant and Cell Therapy P...

                            Details : It follows a Phase 1 trial in healthy volunteers whose initial results demonstrated that COH04S1 was safe and well tolerated. COH04S1 is the only COVID-19 vaccine to advance to a Phase 2 trial that includes both SARS-CoV-2 spike and nucleocapsid proteins...

                            Product Name : COH04S1

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            September 14, 2021

                            Lead Product(s) : COH04S1

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            City of Hope

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                            BioTrinity 2025
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                            City of Hope

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                            BioTrinity 2025
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                            Lead Product(s) : CRAd-pk-S-7,Allogeneic Neural Stem Cell

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Calidi Biotherapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Adding Multimedia Calidi Biotherapeutics Announces Exclusive License Agreement with City of Hope and the Unive...

                            Details : The agreement grants to Calidi commercial exclusivity in using neural stem cells with the adenovirus known as CRAd-pk-S-7 for oncolytic virotherapy.

                            Product Name : CRAd-pk-S-7

                            Product Type : Microorganism

                            Upfront Cash : Undisclosed

                            August 16, 2021

                            Lead Product(s) : CRAd-pk-S-7,Allogeneic Neural Stem Cell

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Calidi Biotherapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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