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    [{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Melatonin","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Undisclosed","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Not Applicable","highestDevelopmentStatusID":"1","companyTruncated":"Cleveland Clinic \/ Not Applicable"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Cytocom","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"","productType":"Small molecule","year":"2021","type":"Merger","leadProduct":"CYTO-200","moa":"","graph1":"Gastroenterology","graph2":"Phase II\/ Phase III","graph3":"Cleveland 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Clinic","sponsor":"AriBio","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"PDE5","graph1":"Neurology","graph2":"Phase II","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic Genomic Medicine Institute","highestDevelopmentStatusID":"8","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic Genomic Medicine Institute"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Anixa Biosciences","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Vaccine","year":"2022","type":"Not Applicable","leadProduct":"Ovarian Cancer Vaccine","moa":"ED-AMHR2","graph1":"Oncology","graph2":"Preclinical","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"4","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Synaptogenix","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2023","type":"Agreement","leadProduct":"Bryostatin-1","moa":"","graph1":"Neurology","graph2":"Preclinical","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Synaptogenix","highestDevelopmentStatusID":"4","companyTruncated":"Cleveland Clinic \/ Synaptogenix"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Anixa Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Vaccine","year":"2024","type":"Partnership","leadProduct":"Alpha-lactalbumin-based Vaccine","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"6","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"TFF Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"14","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"NeuroTherapia","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Series B Financing","leadProduct":"NTRX-07","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Cleveland Clinic","amount2":0.01,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"14","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"}]

    Find Clinical Drug Pipeline Developments & Deals by Cleveland Clinic

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                            01

                            Cleveland Clinic

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                            Lead Product(s) : NTRX-07

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Recipient : NeuroTherapia

                            Deal Size : $12.3 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            NeuroTherapia Raises $12.3M in the First Close of its Series B Financing

                            Details : NeuroTherapia will use this funding primarily for the continued clinical development of NTRX-07, an orally available cannabinoid receptor agonist, for the treatment of Alzheimer's disease

                            Brand Name : NTRX-07

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 06, 2024

                            Lead Product(s) : NTRX-07

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Recipient : NeuroTherapia

                            Deal Size : $12.3 million

                            Deal Type : Series B Financing

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                            02

                            Cleveland Clinic

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : TFF Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            TFF Pharmaceuticals and Cleveland Clinic to Advance Influenza Vaccine Candidates

                            Details : TFF collaborates with Cleveland to advance multiple multivalent universal influenza vaccines, which are being evaluated in early-stage clinical trials to protect against seasonal & pandemic viruses.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            May 20, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : TFF Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

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                            Lead Product(s) : Alpha-lactalbumin-based Vaccine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Anixa Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            Anixa Expands Partnership with Cleveland Clinic to Develop Additional Cancer Vaccines

                            Details : Under the expanded partnership, companies will co-develop vaccines for cancers. Cleveland Clinic is conducting a Phase 1 trial for triple-negative breast cancer.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            May 08, 2024

                            Lead Product(s) : Alpha-lactalbumin-based Vaccine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Anixa Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            04

                            Cleveland Clinic

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                            Lead Product(s) : Bryostatin-1

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Synaptogenix

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Synaptogenix and Cleveland Clinic to Submit Investigational New Drug (IND) Application to FDA for Clinical Tri...

                            Details : The agreement aims to conduct a phase 1 trial of Bryostatin-1, a small molecule that works by activating protein kinase C, in multiple sclerosis (MS).

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            July 19, 2023

                            Lead Product(s) : Bryostatin-1

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Synaptogenix

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            05

                            Cleveland Clinic

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                            Lead Product(s) : Ovarian Cancer Vaccine

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Anixa Biosciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Anixa Biosciences' Ovarian Cancer CAR-T Therapy to be Presented at the Rivkin Center & American Association of...

                            Details : By developing ovarian cancer vaccine that target alpha-lactalbumin and AMHR2-ED, immune system can destroy breast cancer cells and ovarian cancer cells, respectively, as they arise and ultimately prevent tumors from forming.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            September 12, 2022

                            Lead Product(s) : Ovarian Cancer Vaccine

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Anixa Biosciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : Methylbenzylamine

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Recipient : AriBio

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            The Potential of PDE5 Inhibitors, Such as AriBio’s AR1001, the Lead Clinical Candidate for Alzheimer’s Dis...

                            Details : Positive Phase II trial reported for AR1001, the results confirmed the possibility of developing a unique oral disease-modifying treatment for AD that improves cognitive function. The Company will complete Phase III clinical trials of AR1001 within the n...

                            Brand Name : AR1001

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 20, 2021

                            Lead Product(s) : Methylbenzylamine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Recipient : AriBio

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Anixa Biosciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cleveland Clinic Launches First-of-its-Kind Preventive Breast Cancer Vaccine Study

                            Details : The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            October 26, 2021

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Anixa Biosciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Cleveland Clinic

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                            Lead Product(s) : CYTO-200

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II/ Phase III

                            Recipient : Cytocom

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Cleveland BioLabs, Inc. Files Registration Statement on Form S-4 for Proposed Merger with Cytocom Inc.

                            Details : Combined public entity to develop and commercialize next-generation immune therapies like CYTO-200, that address unmet needs in oncology, infectious disease, inflammation and auto-immune-mediated conditions.

                            Brand Name : CYTO-200

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            February 17, 2021

                            Lead Product(s) : CYTO-200

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II/ Phase III

                            Recipient : Cytocom

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            09

                            Cleveland Clinic

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                            Lead Product(s) : Melatonin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cleveland Clinic Research Shows that Melatonin is a Promising Candidate for Prevention and Treatment of COVID-...

                            Details : Results from a new Cleveland Clinic-led study suggest that melatonin, a hormone that regulates the sleep-wake cycle and is commonly used as an over-the-counter sleep aid, may be a viable treatment option for COVID-19.

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 13, 2020

                            Lead Product(s) : Melatonin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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