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                          01

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Under the license agreement, CNS will obtain an license and rights of TPI 287 (abeotaxane), a potential BBB permeable microtubule inhibitor, currently in development for the treatment of GBM.

                          Product Name : TPI 287

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 30, 2024

                          Lead Product(s) : Abeotaxane,Bevacizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Cortice Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Net proceeds will be used for RTA 744 (berubicin HCl), a novel anthracycline used for brain and CNS oncology, particularly glioblastoma multiforme, an aggressive and incurable brain cancer.

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Undisclosed

                          January 29, 2024

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Alliance Global Partners

                          Deal Size : $4.0 million

                          Deal Type : Public Offering

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                          03

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Berubicin HCl is a cytotoxic anthracycline topoisomerase II inhibitor isolated from cultures of Streptomyces peucetius var. caesius. Under phase 2 clinical development for glioblastoma multiforme.

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          January 17, 2024

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells. It is being evaluated in phase 2 clinical trials for the treatment of glioblastom...

                          Product Name : Berubicin

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 18, 2023

                          Lead Product(s) : Berubicin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells, which is investigated for glioblastoma multiforme.

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          October 11, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cel...

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 07, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Berubicin hydrochloride is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell prolifer...

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          August 03, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 25, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          April 10, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Product Name : RTA 744

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          April 06, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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