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                          01

                          Pharmtech & Ingredients
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                          Pharmtech & Ingredients
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                          Details : Under the license agreement, CNS will obtain an license and rights of TPI 287 (abeotaxane), a potential BBB permeable microtubule inhibitor, currently in development for the treatment of GBM.

                          Brand Name : TPI 287

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 30, 2024

                          Lead Product(s) : Abeotaxane,Bevacizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Cortice Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Net proceeds will be used for RTA 744 (berubicin HCl), a novel anthracycline used for brain and CNS oncology, particularly glioblastoma multiforme, an aggressive and incurable brain cancer.

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          January 29, 2024

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Alliance Global Partners

                          Deal Size : $4.0 million

                          Deal Type : Public Offering

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Berubicin HCl is a cytotoxic anthracycline topoisomerase II inhibitor isolated from cultures of Streptomyces peucetius var. caesius. Under phase 2 clinical development for glioblastoma multiforme.

                          Brand Name : Berubicin

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 17, 2024

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells. It is being evaluated in phase 2 clinical trials for the treatment of glioblastom...

                          Brand Name : Berubicin

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 18, 2023

                          Lead Product(s) : Berubicin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells, which is investigated for glioblastoma multiforme.

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 11, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cel...

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 07, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Berubicin hydrochloride is an anthracycline, which is designed to utilize natural processes to induce deoxyribonucleic acid (DNA) damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell prolifer...

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 03, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 25, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 10, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : RTA 744 (berubicin hydrochloride) is an anthracycline, an anticancer agent effective against more types of cancer. Product induces DNA damage in targeted cancer cells by interfering with the action of topoisomerase II, a critical enzyme enabling cell pro...

                          Brand Name : RTA 744

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 06, 2023

                          Lead Product(s) : Berubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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