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Pharmaceuticals","sponsor":"Viatris","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"","productType":"Large molecule","year":"2023","type":"Licensing Agreement","leadProduct":"Cobitolimod","moa":"","graph1":"Gastroenterology","graph2":"Phase III","graph3":"InDex Pharmaceuticals","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Gastroenterology","amount2New":0.050000000000000003,"dosageForm":"Enema","sponsorNew":"InDex Pharmaceuticals \/ Viatris","highestDevelopmentStatusID":"10","companyTruncated":"InDex Pharmaceuticals \/ Viatris"},{"orgOrder":0,"company":"InDex Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Cobitolimod","moa":"","graph1":"Gastroenterology","graph2":"Phase III","graph3":"InDex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals dIscontinues Cobitolimod Phase III Program

                            Details : Kappaproct (cobitolimod) is a Toll-like receptor 9 (TLR9) agonist, that can provide an anti‐inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 21, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Announces that all Patients Needed for the Cobitolimod Dose Selection Milestone Have Com...

                            Details : Kappaproct (cobitolimod) is a Toll-like receptor 9 (TLR9) agonist, that can provide an anti‐inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 11, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Viatris

                            Deal Size : $50 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Announces License Agreement with Viatris Japan to Develop and Commercialize Cobitolimod ...

                            Details : Under the agreement, Viatris will register and commercialize Kappaproct (cobitolimod), a TLR9 agonist being evaluated in phase III as a novel treatment for moderate to severe ulcerative colitis, in Japan.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : $10 million

                            May 31, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Viatris

                            Deal Size : $50 million

                            Deal Type : Licensing Agreement

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                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Announces Positive Results from A Pharmacokinetic (PK) Study with Cobitolimod

                            Details : Kappaproct (cobitolimod) is a Toll-like receptor 9 (TLR9) agonist, that can provide an anti‐inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 15, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Provides Complementary Information on The Phase III Program CONCLUDE With Cobitolimod

                            Details : Kappaproct (cobitolimod) is a Toll-like receptor 9 (TLR9) agonist, that can provide an anti‐inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 14, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Updates the Timeline of The Phase Iii Study CONCLUDE With Cobitolimod

                            Details : Patients responding to Kappaproct (cobitolimod) in the induction study will be eligible to continue in a one-year maintenance study, where they will be treated with either cobitolimod or placebo once every three weeks.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 27, 2023

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            InDex Pharmaceuticals

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Index Pharmaceuticals Announces Successful Interactions With the PMDA for the Clinical Development of Cobitoli...

                            Details : The phase III program for Kappaproct (cobitolimod) in moderate to severe left-sided ulcerative colitis consists of two sequential global induction studies and a year long maintenance study, with patients that have responded to cobitolimod as induction th...

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 16, 2022

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Index Pharmaceuticals Gets New Patent for Cobitolimod Granted in Europe

                            Details : Kappaproct (Cobitolimod) is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9), and previous research has shown clinical efficacy in patients with moderate-to-severe ulcerative colitis.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 13, 2022

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            InDex Pharmaceuticals Enrols First Patient in The Phase III Study CONCLUDE With Cobitolimod in Ulcerative Coli...

                            Details : The study will evaluate the efficacy and safety of first-in-class TLR9 agonist cobitolimod for treatment patients with moderate to severe left-sided ulcerative colitis. The phase III program will form the basis for marketing approval of cobitolimod in ul...

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 24, 2021

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            InDex Pharmaceuticals Gets New Patent for Cobitolimod Granted in Canada

                            Details : The patent provides additional protection for the use of certain dosage regimens of cobitolimod for treating chronic active ulcerative colitis in patients that are not responding or are intolerant to anti-inflammatory therapy.

                            Brand Name : Kappaproct

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 16, 2021

                            Lead Product(s) : Cobitolimod

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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