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BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"exoASO-STAT6","moa":"STAT6","graph1":"Oncology","graph2":"Preclinical","graph3":"Codiak BioSciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Codiak BioSciences \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Codiak BioSciences \/ Inapplicable"},{"orgOrder":0,"company":"Codiak BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"exoASO-STAT6","moa":"STAT6","graph1":"Oncology","graph2":"IND Enabling","graph3":"Codiak 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BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"engEx-AAV","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Discovery","graph3":"Codiak BioSciences","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Codiak BioSciences \/ Inapplicable","highestDevelopmentStatusID":"2","companyTruncated":"Codiak BioSciences \/ Inapplicable"},{"orgOrder":0,"company":"Codiak BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"exoASO-STAT6","moa":"STAT6","graph1":"Oncology","graph2":"Phase I","graph3":"Codiak BioSciences","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Codiak BioSciences

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                          Top Deals by Deal Size (USD bn)

                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : exoVACC is modular vaccine system that utilizes the unique properties of exosomes to deliver antigens and adjuvants simultaneously and selectively to the same antigen presenting cells (APCs), driving an integrated innate, cellular and/or antibody-mediate...

                          Product Name : exoVACC

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          December 10, 2022

                          Lead Product(s) : exoVACC

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : exoSTING (CDK-002) and exoIL-12 demonstrated favorable safety and tolerability profile at repeat doses tested and antitumor activity was observed in both injected and uninjected/distal lesions.

                          Product Name : exoSTING

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 30, 2022

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Codiak’s proprietary exoASO-STAT6 designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.

                          Product Name : exoASO-STAT6

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          June 29, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Codiak’s proprietary engEx Platform is designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 17, 2022

                          Lead Product(s) : engEx-AAV

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Discovery

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Codiak’s exoASO-STAT6 is an engineered exosome investigational therapeutic candidate designed to selectively deliver antisense oligonucleotides (ASOs) to disrupt STAT6 signaling in tumor associated macrophages (TAMs) and induce an anti-tumor immune res...

                          Product Name : exoASO-STAT6

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 10, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Data demonstrated potential for exosome-based vaccine derived from exoVACC platform induce cross-neutralizing antibody protection against strains of coronavirus and antigen-specific and comprehensive immune response against structurally conserved region ...

                          Product Name : exoVACC

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          April 20, 2022

                          Lead Product(s) : exoVACC

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : exoASO-STAT6 is an engineered exosome therapeutic candidate which selectively delivers antisense oligonucleotides to down-modulate STAT6 mRNA expression in TAMs. Precise targeting of STAT6 promotes the switch of TAMs to an M1, T cell attractive, anti-tum...

                          Product Name : exoASO-STAT6

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 18, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : exoSTING (CDK-002) is candidate engineered to incorporate a proprietary STING agonist inside the lumen of the exosome while expressing the exosomal protein, PTGFRN, on the exosome surface to facilitate specific uptake in tumor-resident antigen presenting...

                          Product Name : exoSTING

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 16, 2021

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Codiak has two programs in clinical development and expects to file an IND for exoASO-STAT6 – a novel exosome therapeutic carrying an antisense oligonucleotide (ASO) to target the transcription factor, STAT6 – by the end of the year.

                          Product Name : exoASO-STAT6

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          November 05, 2021

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : ExoSTING is a novel engineered exosome therapeutic candidate currently being investigated in a Phase 1/2 clinical trial as a single agent for the treatment of multiple solid tumors.

                          Product Name : exoSTING

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 22, 2021

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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