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Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"exoASO-STAT6","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"Codiak BioSciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Codiak BioSciences \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Codiak BioSciences \/ Not Applicable"},{"orgOrder":0,"company":"Codiak BioSciences","sponsor":"Sarepta Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Collaboration","leadProduct":"Gene therapy","moa":"","graph1":"Neurology","graph2":"Undisclosed","graph3":"Codiak 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Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Codiak BioSciences \/ Not Applicable"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          PharmaVenue
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                          PharmaVenue
                          Not Confirmed

                          Details : exoVACC is modular vaccine system that utilizes the unique properties of exosomes to deliver antigens and adjuvants simultaneously and selectively to the same antigen presenting cells (APCs), driving an integrated innate, cellular and/or antibody-mediate...

                          Brand Name : Undisclosed

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          October 12, 2022

                          Lead Product(s) : exoVACC

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : Codiak’s exoASO-STAT6 is an engineered exosome investigational therapeutic candidate designed to selectively deliver antisense oligonucleotides (ASOs) to disrupt STAT6 signaling in tumor associated macrophages (TAMs) and induce an anti-tumor immune res...

                          Brand Name : exoASO-STAT6

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 05, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : exoSTING (CDK-002) and exoIL-12 demonstrated favorable safety and tolerability profile at repeat doses tested and antitumor activity was observed in both injected and uninjected/distal lesions.

                          Brand Name : exoSTING

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 30, 2022

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Codiak’s proprietary exoASO-STAT6 designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.

                          Brand Name : exoASO-STAT6

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 29, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Codiak’s proprietary engEx Platform is designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 17, 2022

                          Lead Product(s) : engEx-AAV

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Discovery

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Data demonstrated potential for exosome-based vaccine derived from exoVACC platform induce cross-neutralizing antibody protection against strains of coronavirus and antigen-specific and comprehensive immune response against structurally conserved region ...

                          Brand Name : exoVACC

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          April 20, 2022

                          Lead Product(s) : exoVACC

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : exoASO-STAT6 is an engineered exosome therapeutic candidate which selectively delivers antisense oligonucleotides to down-modulate STAT6 mRNA expression in TAMs. Precise targeting of STAT6 promotes the switch of TAMs to an M1, T cell attractive, anti-tum...

                          Brand Name : exoASO-STAT6

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 18, 2022

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : exoSTING (CDK-002) is candidate engineered to incorporate a proprietary STING agonist inside the lumen of the exosome while expressing the exosomal protein, PTGFRN, on the exosome surface to facilitate specific uptake in tumor-resident antigen presenting...

                          Brand Name : exoSTING

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 16, 2021

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Codiak has two programs in clinical development and expects to file an IND for exoASO-STAT6 – a novel exosome therapeutic carrying an antisense oligonucleotide (ASO) to target the transcription factor, STAT6 – by the end of the year.

                          Brand Name : exoASO-STAT6

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 11, 2021

                          Lead Product(s) : exoASO-STAT6

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : ExoSTING is a novel engineered exosome therapeutic candidate currently being investigated in a Phase 1/2 clinical trial as a single agent for the treatment of multiple solid tumors.

                          Brand Name : exoSTING

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 22, 2021

                          Lead Product(s) : CDK-002

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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