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    [{"orgOrder":0,"company":"Endo International","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"IRELAND","productType":"Enzyme","year":"2022","type":"Inapplicable","leadProduct":"Collagenase Clostridium Histolyticum","moa":"Collagen hydrolysis","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Endo International","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Endo International \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Endo International \/ Inapplicable"},{"orgOrder":0,"company":"Endo International","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"IRELAND","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Collagenase Clostridium Histolyticum","moa":"Collagen hydrolysis","graph1":"Dermatology","graph2":"Approved 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    Collagenase Clostridium Histolyticum

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                            01

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Approved FDF

                            Sponsor : Mallinckrodt Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Mallinckrodt and Endo Get a Bump from Tariffs in $6.7 Billion Merger

                            Details : The companies will merge and integrate their entire pipelines, including Xiaflex (collagenase clostridium histolyticum) for treating adult patients with Dupuytren’s contracture.

                            Product Name : Xiaflex

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            March 13, 2025

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Approved FDF

                            Sponsor : Mallinckrodt Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            Endo Pharm

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo to Present Peyronie’s Disease Findings at Urological Association Meeting

                            Details : Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.

                            Product Name : Xiaflex

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 12, 2025

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Endo Pharm

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            John Elway Partners with Endo to Promote XIAFLEX® for Dupuytren's Contracture

                            Details : Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.

                            Product Name : Xiaflex

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 20, 2024

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo Provides Top-Line Results from Phase 2 Study of Collagenase Clostridium Histolyticum (CCH) in Participant...

                            Details : EN3835 (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is being investigated for plantar fibromatosis.

                            Product Name : Qwo

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 13, 2023

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo Presents New Qwo® (collagenase clostridium histolyticum-aaes) Data at the American Society for Dermatolo...

                            Details : Qwo® (collagenase clostridium histolyticum-aaes), an FDA-approved injectable is used for the treatment of moderate to severe cellulite in the buttocks of adult women. QWO is contraindicated in patients with a history of hypersensitivity to collagenase.

                            Product Name : Qwo

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            July 10, 2022

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo Aesthetics to Introduce New Clinical Study of Qwo® (collagenase clostridium histolyticum-aaes) at the An...

                            Details : Qwo (collagenase clostridium histolyticum-aaes), is a prescription medicine used to treat moderate to severe cellulite in the buttocks of adult women, may cause serious side effects including allergic.

                            Product Name : Qwo

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 05, 2022

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo Provides Top-Line Results from Phase 2 Study of Collagenase Clostridium Histolyticum (CCH) in Participant...

                            Details : Phase 2 study participants receiving up to 3 doses of Xiaflex (collagenase clostridium histolyticum) showed improvement in change from baseline ifor affected shoulder at Day 95, compared to those study participants receiving placebo was not significant.

                            Product Name : Qwo

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            January 07, 2022

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Endo Pharm

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo to Present Qwo™ (Collagenase Clostridium Histolyticum-Aaes) Data at Vegas Cosmetic Surgery & Aesthetic ...

                            Details : Endo International plc presentation will include a general overview of collagenase clostridium histolyticum-aaes and will review data from the product's phase 3 pooled trial analyses.

                            Product Name : Xiaflex

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 24, 2020

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Endo International

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Endo Aesthetics Data to be Featured in Five Presentations at the American Society for Dermatologic Surgery's A...

                            Details : Endo International will present data relevant to the use of Endo Aesthetics' Qwo™ (collagenase clostridium histolyticum-aaes) for the treatment of moderate to severe cellulite in the buttocks of adult women during the American Society for Dermatologic ...

                            Product Name : Qwo

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 10, 2020

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            BioSpecifics

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                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Study Phase : Approved FDF

                            Sponsor : Endo Pharm

                            Deal Size : $540.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Endo Completes Acquisition of BioSpecifics

                            Details : BioSpecifics received a royalty stream from Endo related to Endo's collagenase-based therapies, which currently include XIAFLEX, marketed by Endo Pharmaceuticals.

                            Product Name : Xiaflex

                            Product Type : Enzyme

                            Upfront Cash : $540.0 million

                            February 12, 2020

                            Lead Product(s) : Collagenase Clostridium Histolyticum

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved FDF

                            Sponsor : Endo Pharm

                            Deal Size : $540.0 million

                            Deal Type : Acquisition

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