17
ALL17
Context TherapeuticsYear
17
ALL2
20253
20243
20237
20221
20211
2020DEALS // DEV.
17
ALL3
Deals14
DevelopmentsCountry
17
ALL17
U.S.A17
ALL13
Inapplicable1
Integral Molecular1
Lonza Inc & Lonza America Inc1
Nextech1
The Menarini GroupTherapeutic Area
17
ALL17
OncologyStudy Phase
17
ALL9
Phase II2
Phase I3
IND Enabling3
PreclinicalDeal Type
17
ALL1
Agreement1
Collaboration14
Inapplicable1
Private PlacementProduct Type
17
ALL8
Antibody9
Other Small MoleculeDosage Form
17
ALL8
Oral Tablet, Extended Release9
UndisclosedLead Product
17
ALL8
CTIM-769
OnapristoneTarget
17
ALL8
CLDN6/CD39
PRIntegral’s Out-Licensed Bispecific Antibody Enters Solid Tumor Trial
Details : CTIM-76 is an anti-Claudin 6 (CLDN6) bispecific antibody, which is currently being evaluated for the treatment of platinum-refractory/resistant ovarian cancer.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
March 06, 2025
Context Therapeutics Doses First Patient in Phase 1 Trial of CTIM-76
Details : CTIM-76 is a CLDN6 x CD3 T cell engaging bispecific antibody. It is being evaluated for the treatment of Claudin 6-Positive gynecologic and testicular cancers.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
January 14, 2025
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Nextech
Deal Size : $100.0 million
Deal Type : Private Placement
Context Therapeutics Announces $100 Million Private Placement
Details : The net proceeds will be used to fund the clinical development of CTIM-76, under early-stage trials for CLDN6-positive ovarian, lung, and testicular tumors.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Undisclosed
February 05, 2024
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Nextech
Deal Size : $100.0 million
Deal Type : Private Placement
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Context Therapeutics Announces FDA Clearance of IND for Phase 1 Trial of CTIM-76
Details : CTIM-76 is a Claudin 6 x CD3 T cell engaging bispecific antibody, which is currently being evaluated for the treatment of patients with CLDN6-positive gynecologic and testicular cancers.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
February 05, 2024
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Context Submits IND Application to Evaluate CTIM-76 in Claudin 6-Positive Cancers
Details : CTIM-76 is a CLDN6 x CD3 T cell engaging bispecific antibody. It is being evaluated for the treatment of Claudin 6-Positive gynecologic and testicular cancers.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
January 04, 2024
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CTIM-76, is a CLDN6 x CD3 bispecific antibody that incorporates a highly selective CLDN6 binding arm and a CD3 binding single-chain Fv domain in an IgG format. It is is potent with specific lysis of CLDN6+ cancer cells over normal cells.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
October 31, 2023
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Lonza Inc & Lonza America Inc
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the agreement, Lonza will support the development and manufacturing of CTIM-76, a CLDN6 x CD3 bispecific antibody clinical candidate. The bispecific antibody-based therapy is being developed to redirect T-cell mediated lysis toward malignant cells ...
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Undisclosed
September 01, 2023
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Lonza Inc & Lonza America Inc
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Onapristone,Anastrozole
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ONA-XR (onapristone) is a selective progesterone receptor (PR) antagonist designed to block both ligand dependent and ligand-independent activity of PR which downregulates cancer stem cellmobilization, and blocking immune evasion.
Product Name : ONA-XR
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 02, 2023
Lead Product(s) : Onapristone,Anastrozole
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Integral Molecular
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CTIM-76, a T cell-engaging bispecific antibody, as its lead clinical development candidate to target Claudin 6 (CLDN6) positive cancers.
Product Name : CTIM-76
Product Type : Antibody
Upfront Cash : Inapplicable
November 29, 2022
Lead Product(s) : CTIM-76
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Integral Molecular
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Onapristone,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ONA-XR (onapristone extended release) is a potent and specific antagonist of the progesterone receptor (PR) that is orally administered. Preclinical and clinical data suggest that ONA-XR has anticancer activity by inhibiting progesterone receptor binding...
Product Name : ONA-XR
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 21, 2022
Lead Product(s) : Onapristone,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable