[{"orgOrder":0,"company":"Context Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Onapristone","moa":"PR","graph1":"Oncology","graph2":"Phase II","graph3":"Context Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Context Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Context Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Context Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Onapristone","moa":"PR","graph1":"Oncology","graph2":"Phase II","graph3":"Context Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Context Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : The context will obtain from BioAtla an exclusive, worldwide license to develop, manufacture, and commercialize BA3362, Nectin-4 x CD3 TCE for the treatment of neoplasms.

                          Brand Name : BA3362

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 23, 2024

                          Lead Product(s) : BA3362

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : BioAtla

                          Deal Size : $133.5 million

                          Deal Type : Licensing Agreement

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                          02

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Context Therapeutics acquires CT-95, a potential first-in-class mesothelin x CD3 bispecific antibody, which is ready Phase 1-ready T cell Engager for the treatment of solid tumors.

                          Brand Name : CT-95

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          July 10, 2024

                          Lead Product(s) : CT-95

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Recipient : Link Immunotherapeutics

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          03

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of CTIM-76, under early-stage trials for CLDN6-positive ovarian, lung, and testicular tumors.

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          May 02, 2024

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Nextech

                          Deal Size : $100.0 million

                          Deal Type : Private Placement

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                          04

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : CTIM-76 is a Claudin 6 x CD3 T cell engaging bispecific antibody, which is currently being evaluated for the treatment of patients with CLDN6-positive gynecologic and testicular cancers.

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 02, 2024

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : CTIM-76 is a CLDN6 x CD3 T cell engaging bispecific antibody. It is being evaluated for the treatment of Claudin 6-Positive gynecologic and testicular cancers.

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 01, 2024

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : CTIM-76, is a CLDN6 x CD3 bispecific antibody that incorporates a highly selective CLDN6 binding arm and a CD3 binding single-chain Fv domain in an IgG format. It is is potent with specific lysis of CLDN6+ cancer cells over normal cells.

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 31, 2023

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : ONA-XR (onapristone) is a selective progesterone receptor (PR) antagonist designed to block both ligand dependent and ligand-independent activity of PR which downregulates cancer stem cellmobilization, and blocking immune evasion.

                          Brand Name : ONA-XR

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 06, 2023

                          Lead Product(s) : Onapristone,Anastrozole

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the agreement, Lonza will support the development and manufacturing of CTIM-76, a CLDN6 x CD3 bispecific antibody clinical candidate. The bispecific antibody-based therapy is being developed to redirect T-cell mediated lysis toward malignant cells ...

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 09, 2023

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Lonza Inc & Lonza America Inc

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          09

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : ONA-XR (onapristone extended release) is a potent and specific antagonist of the progesterone receptor (PR) that is orally administered. Currently, there are no approved therapies that selectively target PR+ cancers.

                          Brand Name : ONA-XR

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 08, 2022

                          Lead Product(s) : Onapristone,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : CTIM-76, a T cell-engaging bispecific antibody, as its lead clinical development candidate to target Claudin 6 (CLDN6) positive cancers.

                          Brand Name : CTIM-76

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 29, 2022

                          Lead Product(s) : CTIM-76

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Integral Molecular

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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