Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $1,700.0 million
Deal Type : Acquisition
Sobi Completes Acquisition of CTI BioPharma Corp.
Details : The acquisition strengthens Sobi’s leading haematology franchise by adding Vonjo (pacritinib), a novel oral kinase inhibitor that inhibits JAK2, IRAK1 and ACRV1, while sparing JAK1, for the treatment of adults with myelofibrosis. Vonjo obtained acceler...
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : $1,700.0 million
June 26, 2023
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $1,700.0 million
Deal Type : Acquisition
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $1,700.0 million
Deal Type : Acquisition
Details : The acquisition will diversify Sobi's portfolio of leading hematology medicines through CTI's lead product, VONJO® (pacritinib), which is FDA-approved for the treatment of adult myelofibrosis patients with a platelet count below 50 x109/L.
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : $1,700.0 million
May 10, 2023
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $1,700.0 million
Deal Type : Acquisition
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Vonjo (Pacritinib) is an oral kinase inhibitor with activity against wild type Janus Associated Kinase 2 (JAK2), mutant JAK2V617F form, IRAK1, ACVR1 (ALK2) and FMS-like tyrosine kinase 3 (FLT3).
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 03, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : On duplicate assays, Vonjo (pacritinib) was shown to be a more potent inhibitor of ACVR1 compared to momelotinib, with a half maximal inhibitory concentration (IC50) of 10.8 and 22.6 nM versus34.9 and 70.2 nM, respectively.
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 21, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Vonjo (pacritinib) is an oral kinase inhibitor with activity against wild type JAK2, mutant JAK2V617F form and FMS-like tyrosine kinase 3 (FLT3), which contribute to signaling of a number of cytokines and growth factors that are important for hematopoies...
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 10, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Vonjo (Pacritinib) is an oral kinase inhibitor with activity against wild type JAK2, mutant JAK2V617F form and FMS-like tyrosine kinase 3, which contribute to signaling of a number of cytokines and growth factors that are important for hematopoiesis and ...
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 27, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
NCCN Guidelines® Recommend VONJO™ (pacritinib) for the Treatment of Myeloproliferative Neoplasms
Details : At clinically relevant concentrations, pacritinib does not inhibit JAK1. Pacritinib exhibits inhibitory activity against additional cellular kinases (such as CSF1R and IRAK1), the clinical relevance of which is unknown.
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 14, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Recipient : Onco360
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FDA’s approval of VONJO (pacritinib) is based upon results of PERSIST-2 clinical trial indicate that 29% of myelofibrosis patients with baseline platelet levels of less than 50 x 109/L obtained spleen volume reductions of at least 35% during first six ...
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 04, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Recipient : Onco360
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Vonjo (pacritinib), is an oral kinase inhibitor with activity against wild type JAK2, mutant JAK2V617F form and FLT3, contribute to signaling of a number of cytokines and growth factors that are important for hematopoiesis and immune function.
Brand Name : Vonjo
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 01, 2022
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Pacritinib, a JAK 2/interleukin-1 receptor–associated kinase 1 (IRAK1) inhibitor that does not inhibit JAK1, is in development for use in patients with myelofibrosis who have thrombocytopenia.
Brand Name : PAC203
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 13, 2021
Lead Product(s) : Pacritinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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