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Inapplicable"},{"orgOrder":0,"company":"CureVac","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"GERMANY","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"CV0501","moa":"SARS-CoV-2-viral spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase I","graph3":"CureVac","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"CureVac \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"CureVac \/ Inapplicable"},{"orgOrder":0,"company":"CureVac","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"GERMANY","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"CV0501","moa":"SARS-CoV-2-viral spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase 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                          01

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Flu mRNA (GSK4382276A) is a intramuscularly administered mRNA-based multivalent seasonal influenza vaccine, which is being evaluated for the treatment of seasonal influenza.

                          Product Name : GSK4382276A

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          May 28, 2024

                          Lead Product(s) : GSK4382276A

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : GSK

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : CV0701 is a biovalent vaccine candidate, which encodes the spike protein of the omicron BA.4-5 variant and it is under phase 2 clinical development for the treatment of Covid-19 infection.

                          Product Name : CV0701

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          May 01, 2024

                          Lead Product(s) : CV0701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : GSK

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : H5N1 is a pre-pandemic vaccine candidate currently undergoing evaluation in early-stage clinical trials with patients for treating the H5N1 subtype of influenza A virus.

                          Product Name : H5N1

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          April 24, 2024

                          Lead Product(s) : H5N1

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : A collaboration aims to develop mRNA-based cancer vaccines for high unmet needs in hematological and solid cancers, with MD Anderson leading phase 1/2 studies.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          April 16, 2024

                          Lead Product(s) : mRNA-Based Vaccine

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : MD Anderson Cancer Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          05

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Flu mRNA (GSK4382276A) is a intramuscularly administered mRNA-based multivalent seasonal influenza vaccine, which is being evaluated for the treatment of seasonal influenza.

                          Product Name : GSK4382276A

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          April 04, 2024

                          Lead Product(s) : GSK4382276A

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : GSK

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Through a licensing agreement, GSK will acquire full rights from Curevac of Flu mRNA (GSK4382276) to develop, manufacture, and commercialize globally mRNA candidate vaccines for influenza.

                          Product Name : GSK4382276A

                          Product Type : Vaccine

                          Upfront Cash : $429.2 million

                          March 07, 2024

                          Lead Product(s) : GSK4382276A

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Biogen

                          Deal Size : $1,556.0 million

                          Deal Type : Licensing Agreement

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                          07

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : CV0501 (mRNA-based prophylactic vaccine) is a monovalent mRNA vaccine candidate using modified nucleosides, encoding the S protein of Omicron BA.1 and maintaining the same pre-fusion stabilizing mutations in S protein.

                          Product Name : CV0501

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          October 02, 2023

                          Lead Product(s) : CV0501

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Goldman Sachs & Co.

                          Deal Size : $250.0 million

                          Deal Type : Public Offering

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                          08

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : The Company intends to use the net proceeds from the offering primarily for the development of CV0501(mRNA-based prophylactic vaccine), and for general corporate purposes.

                          Product Name : CV0501

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          July 02, 2023

                          Lead Product(s) : CV0501

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Goldman Sachs & Co. LLC

                          Deal Size : $200.0 million

                          Deal Type : Public Offering

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                          09

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : CVGBM is CureVac's first investigational cancer vaccine based on its proprietary second-generation mRNA backbone designed for improved mRNA translation and increased as well as extended protein expression, which is investigated for the treatment of Gliob...

                          Product Name : CVGBM

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          June 20, 2023

                          Lead Product(s) : CVGBM

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : CV0501 was designed with specifically optimized non-coding regions aiming to deliver improved mRNA translation for increased and extended protein expression compared to the first-generation mRNA backbone.

                          Product Name : CV0501

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          June 01, 2023

                          Lead Product(s) : CV0501

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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