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    [{"orgOrder":0,"company":"Cybrexa Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Exatecan","moa":"DNA Topoisomerase I","graph1":"Oncology","graph2":"Preclinical","graph3":"Cybrexa Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Cybrexa Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Cybrexa Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cybrexa Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Alphale-Exatecan","moa":"DNA Topoisomerase I","graph1":"Oncology","graph2":"Preclinical","graph3":"Cybrexa 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Capital"},{"orgOrder":0,"company":"Cybrexa Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2021","type":"Not Applicable","leadProduct":"Alphalex-exatecan","moa":"Topoisomerase I","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Cybrexa Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Cybrexa Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Cybrexa Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cybrexa Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2021","type":"Not Applicable","leadProduct":"Alphalex-exatecan","moa":"Topoisomerase I","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Cybrexa 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Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2022","type":"Not Applicable","leadProduct":"CBX-12","moa":"Topoisomerase 1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Cybrexa Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Cybrexa Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Cybrexa Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cybrexa Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2024","type":"Not Applicable","leadProduct":"CBX-12","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Cybrexa Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Cybrexa Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"Cybrexa Therapeutics \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Cybrexa Therapeutics

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                            01

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : CBX-12

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Doses First Patient in Peptide-Drug Conjugate Trial For Ovarian Cancer

                            Details : CBX-12 is a PDC that utilizes Cybrexa’s alphalex technology to enhance delivery of exatecan to tumor cells and is composed of a pHLIP. It is being evaluated for platinum-resistant ovarian cancer.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            October 07, 2024

                            Lead Product(s) : CBX-12

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Lead Product(s) : CBX-12

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Presents Findings from First-in-Human Study of CBX-12 as a Plenary Oral Presentation at 3...

                            Details : CBX-12 is a PDC that includes the highly potent topoisomerase I inhibitor exatecan. CBX-12 demonstrated safety and tolerability, without significant gastrointestinal toxicity.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            October 28, 2022

                            Lead Product(s) : CBX-12

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics to Present at AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Ca...

                            Details : Study evaluating the efficacy of CBX-12 (alphalex™-exatecan) in combination with PD-1- and CTLA4-targeted immune checkpoint inhibitors in preclinical cancer models. CBX-12 is a novel treatment for solid tumors that includes a highly potent topoisomeras...

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            September 28, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics to Present at BTIG Virtual Biotechnology Conference 2021

                            Details : CBX-12 is a novel treatment for solid tumors that includes a highly potent topoisomerase I inhibitor payload that is in the same class as the payloads used by antibody-drug conjugates (ADCs) ENHERTU® and TRODELVY™.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            August 04, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Receives Green Light from FDA on Investigational New Drug Application for CBX-12 (alphale...

                            Details : CBX-12 is a novel treatment for solid tumors that includes a highly potent topoisomerase I inhibitor payload that is in the same class as the payloads used by antibody-drug conjugates (ADCs) ENHERTU® and TRODELVY™.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            March 22, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : HighCape Capital

                            Deal Size : $25.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Closes $25 Million Series B Financing

                            Details : Proceeds from the financing will be used to support the planned advancement of Cybrexa’s lead candidate CBX-12 (alphalex™-exatecan) into the clinic. The first patient dosing in the Phase 1 study is expected in the first half of 2021.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            March 10, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : HighCape Capital

                            Deal Size : $25.0 million

                            Deal Type : Series B Financing

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                            07

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Enters Cooperative Research and Development Agreement (CRADA) with U.S. National Cancer I...

                            Details : Cybrexa and NCI to collaborate on clinical development of Cybrexa’s lead candidate, CBX-12, to assess the safety and efficacy in oncology patients with solid tumors.

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            February 24, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            08

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Reports Positive Results from GLP Toxicology Study of Lead Candidate CBX-12 (Alphalex™-...

                            Details : In the GLP toxicology studies CBX-12 was delivered via IV infusion, and based on multiple parameters, including mortality, clinical observations, body weights and food consumption, the results established a significant therapeutic index of ~20X over exat...

                            Brand Name : CBX-12

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            January 28, 2021

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Cybrexa Therapeutics

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                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics Completes Successful Pre-IND Meeting With FDA for CBX-12 (alphalex™-exatecan), a Novel ...

                            Details : The Phase I portion of the study will establish the safety profile and a recommended Phase II dose (RP2D). This initial clinical trial will also evaluate efficacy across a number of solid tumors and establish proof of mechanism for the alphalex™ platf...

                            Brand Name : CBX-12

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 07, 2020

                            Lead Product(s) : Alphalex-exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Cybrexa Therapeutics

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                            American Pharma Summit
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                            Lead Product(s) : Alphale-Exatecan

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cybrexa Therapeutics to Present First Efficacy & Safety Data From Its Lead Program CBX-12 and Data From CBX-13...

                            Details : CBX-12 demonstrated remarkable efficacy across HER2-negative solid tumors in preclinical models. It displayed enhanced stability in plasma in vivo and demonstrated exquisite selectivity for tumor over normal tissues in mouse tumor models.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 15, 2020

                            Lead Product(s) : Alphale-Exatecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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