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Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Adaptimmune Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Adaptimmune Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"BriaCell Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"Bria-OTS","moa":"","graph1":"Technology","graph2":"Approved","graph3":"BriaCell Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"BriaCell Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"BriaCell Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Allogene Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"ALLO-316","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Allogene Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Allogene Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Allogene Therapeutics \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals for (-)-Cyclophosphamide

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Letetresgene autoleucel (lete-cel) is an immunotherapy that works by targeting and binding to tumor cells that overexpress the cancer-testis antigens NY-ESO-1 and LAGE-1.

                          Brand Name : Lete-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 13, 2024

                          Lead Product(s) : Letetresgene Autoleucel,Fludarabine Phosphate,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Aucatzyl (obecabtagene autoleucel) is a CD19 CAR T cell investigational therapy. It is indicated for the treatment of relapsed/refractory adult B-cell Acute Lymphoblastic Leukemia.

                          Brand Name : Aucatzyl

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 11, 2024

                          Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : NKX019 is an allogeneic CD19 directed, off-the-shelf immunotherapy candidate, which is being evaluated for the treatment of systemic lupus erythematosus.

                          Brand Name : NKX019

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 11, 2024

                          Lead Product(s) : NKX019,Cyclophosphamide

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : SC291 is a CD19-directed allogeneic CAR T cell therapy developed using Sana's hypoimmune platform for the treatment of B-cell mediated autoimmune diseases (AID).

                          Brand Name : SC291

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 04, 2024

                          Lead Product(s) : SC291,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The US FDA granted Regenerative Medicine Advanced Therapy (RMAT) designation to ALLO-316 for the treatment of adult patients with CD70 positive advanced or metastatic renal cell carcinoma.

                          Brand Name : ALLO-316

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 29, 2024

                          Lead Product(s) : ALLO-316,ALLO-647,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Bria-IMT (SV-BR-1-GM) is an off-the-shelf targeted cellular immunotherapy. It is being evaluated in combination with Zynyz (retifanlimab-dlwr) for the treatment of Metastatic breast cancer.

                          Brand Name : Bria-IMT

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          October 22, 2024

                          Lead Product(s) : SV-BR-1-GM,Cyclophosphamide,Retifanlimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Multikine (Leukocyte Interleukin, Injection), a true first-line cancer therapy, received Orphan Drug designation from the FDA for neoadjuvant therapy in squamous cell carcinoma of the head and neck.

                          Brand Name : Multikine

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 22, 2024

                          Lead Product(s) : Leukocyte Interleukin,Cyclophosphamide,Indomethacin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Bria-IMT is a genetically engineered human breast cancer cell line with features of immune cells. It is clinically used as a targeted immunotherapy for treating breast cancer.

                          Brand Name : Bria-IMT

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          October 15, 2024

                          Lead Product(s) : SV-BR-1-GM,Cyclophosphamide,Retifanlimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ADI-001 is a first-in-class allogeneic gamma delta (γδ) CAR T cell therapy, which is being developed for the treatment of pattients with lupus nephritis.

                          Brand Name : ADI-001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 30, 2024

                          Lead Product(s) : ADI-001,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Bria-IMT is a genetically engineered human breast cancer cell line with features of immune cells. It is clinically used as a targeted immunotherapy for treating breast cancer.

                          Brand Name : Bria-IMT

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          September 11, 2024

                          Lead Product(s) : SV-BR-1-GM,Cyclophosphamide,Retifanlimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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