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    [{"orgOrder":0,"company":"Cynata Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"AUSTRALIA","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"CYP-002","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II","graph3":"Cynata Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Cynata Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Cynata Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cynata Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"AUSTRALIA","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"MCA-derived mesenchymal stem cells","moa":"","graph1":"Immunology","graph2":"Phase 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Applicable","leadProduct":"CYP-001","moa":"","graph1":"Immunology","graph2":"Phase II","graph3":"Cynata Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Cynata Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Cynata Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Cynata Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Podiatry","country":"AUSTRALIA","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"CYP-006TK","moa":"","graph1":"Podiatry","graph2":"Phase I","graph3":"Cynata Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Podiatry","amount2New":0,"dosageForm":"Dressing","sponsorNew":"Cynata Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Cynata Therapeutics \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Cynata Therapeutics

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                            01

                            Cynata Therapeutics

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                            Lead Product(s) : CYP-006TK

                            Therapeutic Area : Podiatry

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cynata Therapeutics Completes Enrollment in Phase 1 Trial of CYP-006TK for Foot Ulcers

                            Details : CYP-006TK is a topical wound dressing, cell and gene therapy drug candidate, which is currently being evaluated for the treatment of patients with diabetic foot ulcers.

                            Brand Name : CYP-006TK

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 09, 2024

                            Lead Product(s) : CYP-006TK

                            Therapeutic Area : Podiatry

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Cynata Therapeutics

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                            Lead Product(s) : CYP-001,Prednisone

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            First Patient Treated in Phase 2 GvHD Trial

                            Details : CYP-001 is Cynata's Cymerus™ off-the-shelf iPSC[1]-derived MSC[2] product candidate for intravenous infusion, which is being evaluated for the treatment of acute graft versus host disease.

                            Brand Name : CYP-001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 04, 2024

                            Lead Product(s) : CYP-001,Prednisone

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Cynata Therapeutics

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                            Lead Product(s) : CYP-006TK

                            Therapeutic Area : Podiatry

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Encouraging Initial Data from CYP-006TK Diabetic Foot Ulcer Clinical Trial

                            Details : CYP-006TK consists of allogenic mesenchymoangioblast-derived mesenchymal stem cells or Cymerus™ MSCs, seeded onto a heptylamine plasma polymer-coated silicone dressing for diabetic foot ulcers.

                            Brand Name : CYP-006TK

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 26, 2024

                            Lead Product(s) : CYP-006TK

                            Therapeutic Area : Podiatry

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Cynata Therapeutics

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                            Lead Product(s) : Mesenchymoangioblast-derived Mesenchymal Stem Cells

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            US FDA Clears IND for Cynata's Phase 2 Clinical Trial of CYP-001 in GvHD

                            Details : CYP-001 (mesenchymoangioblast-derived mesenchymal stem cells) met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial.

                            Brand Name : CYP-001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 26, 2022

                            Lead Product(s) : Mesenchymoangioblast-derived Mesenchymal Stem Cells

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Cynata Therapeutics

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                            Lead Product(s) : Cymerus mesenchymal stem cells

                            Therapeutic Area : Podiatry

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ethics Approval for Cynata’s Clinical Trial in Diabetic Foot Ulcers

                            Details : This will be the first clinical trial to utilise CYP-006TK, a polymer-coated silicon dressing (seeded with Cymerus MSCs) that Cynata has licensed from TekCyte Pty Ltd (TekCyte).

                            Brand Name : CYP-006TK

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            June 30, 2021

                            Lead Product(s) : Cymerus mesenchymal stem cells

                            Therapeutic Area : Podiatry

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Cynata Therapeutics

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                            Lead Product(s) : CYP-001

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cynata Expands MEND Clinical Trial in Covid-19 and Respiratory Failure

                            Details : In the initial stage, the trial was designed to assess the early efficacy of Cymerus MSCs in Covid-19 patients admitted to intensive care. The trial will now analyse the early efficacy of Cymerus MSCs in patients with respiratory failure.

                            Brand Name : Cymerus MSCs

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 29, 2021

                            Lead Product(s) : CYP-001

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Cynata Therapeutics

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                            Lead Product(s) : Cymerus mesenchymal stem cell

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            New Preclinical Study to Investigate the High Potency of Cymerus™ MSCs

                            Details : Clinical trials of Cymerus MSC products in osteoarthritis (Phase 3) and in severe complications arising from COVID-19 (Phase 2) are currently ongoing.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 02, 2021

                            Lead Product(s) : Cymerus mesenchymal stem cell

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Cynata Therapeutics

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                            Lead Product(s) : Cymerus mesenchymal stem cell

                            Therapeutic Area : Podiatry

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cynata Advances Planned Clinical Trial in Diabetic Foot Ulcers in MoU With TekCyte

                            Details : Cynata plans to undertake a clinical trial of its Cymerus MSC product in patients with diabetic foot ulcers based on this solid pre-clinical foundation and utilising the TekCyte technology.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 01, 2021

                            Lead Product(s) : Cymerus mesenchymal stem cell

                            Therapeutic Area : Podiatry

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Cynata Therapeutics

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                            Lead Product(s) : Cymerus mesenchymal stem cells

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cymerus MSCs Demonstrate Efficacy in Preclinical Lung Disease Study

                            Details : Treatment with Cynata’s Cymerus MSCs led to statistically significant improvements in multiple harmful effects of IPF, including interstitial fibrosis, dynamic lung compliance and airway resistance.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 08, 2020

                            Lead Product(s) : Cymerus mesenchymal stem cells

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Cynata Therapeutics

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                            Lead Product(s) : MCA-derived mesenchymal stem cells

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cynata Completes Phase 1 GvHD Clinical Trial Follow-up with Positive Results

                            Details : The Phase 1 trial, which was the world’s first clinical trial of an allogeneic iPSC-derived MSC product, evaluated the safety and efficacy of CYP-001 for the treatment of patients with steroid-resistant acute graft-versus-host disease (GvHD).

                            Brand Name : CYP-001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 30, 2020

                            Lead Product(s) : MCA-derived mesenchymal stem cells

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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