Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Cynata Therapeutics Completes Enrollment in Phase 1 Trial of CYP-006TK for Foot Ulcers
Details : CYP-006TK is a topical wound dressing, cell and gene therapy drug candidate, which is currently being evaluated for the treatment of patients with diabetic foot ulcers.
Brand Name : CYP-006TK
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 09, 2024
Lead Product(s) : CYP-001,Prednisone
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
First Patient Treated in Phase 2 GvHD Trial
Details : CYP-001 is Cynata's Cymerus™ off-the-shelf iPSC[1]-derived MSC[2] product candidate for intravenous infusion, which is being evaluated for the treatment of acute graft versus host disease.
Brand Name : CYP-001
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 04, 2024
Lead Product(s) : CYP-001,Prednisone
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Encouraging Initial Data from CYP-006TK Diabetic Foot Ulcer Clinical Trial
Details : CYP-006TK consists of allogenic mesenchymoangioblast-derived mesenchymal stem cells or Cymerus™ MSCs, seeded onto a heptylamine plasma polymer-coated silicone dressing for diabetic foot ulcers.
Brand Name : CYP-006TK
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 26, 2024
Lead Product(s) : Mesenchymoangioblast-derived Mesenchymal Stem Cells
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
US FDA Clears IND for Cynata's Phase 2 Clinical Trial of CYP-001 in GvHD
Details : CYP-001 (mesenchymoangioblast-derived mesenchymal stem cells) met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial.
Brand Name : CYP-001
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 26, 2022
Lead Product(s) : Mesenchymoangioblast-derived Mesenchymal Stem Cells
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cymerus mesenchymal stem cells
Therapeutic Area : Podiatry
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Ethics Approval for Cynata’s Clinical Trial in Diabetic Foot Ulcers
Details : This will be the first clinical trial to utilise CYP-006TK, a polymer-coated silicon dressing (seeded with Cymerus MSCs) that Cynata has licensed from TekCyte Pty Ltd (TekCyte).
Brand Name : CYP-006TK
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 30, 2021
Lead Product(s) : Cymerus mesenchymal stem cells
Therapeutic Area : Podiatry
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CYP-001
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cynata Expands MEND Clinical Trial in Covid-19 and Respiratory Failure
Details : In the initial stage, the trial was designed to assess the early efficacy of Cymerus MSCs in Covid-19 patients admitted to intensive care. The trial will now analyse the early efficacy of Cymerus MSCs in patients with respiratory failure.
Brand Name : Cymerus MSCs
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 29, 2021
Lead Product(s) : CYP-001
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cymerus mesenchymal stem cell
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
New Preclinical Study to Investigate the High Potency of Cymerus™ MSCs
Details : Clinical trials of Cymerus MSC products in osteoarthritis (Phase 3) and in severe complications arising from COVID-19 (Phase 2) are currently ongoing.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 02, 2021
Lead Product(s) : Cymerus mesenchymal stem cell
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cymerus mesenchymal stem cell
Therapeutic Area : Podiatry
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cynata Advances Planned Clinical Trial in Diabetic Foot Ulcers in MoU With TekCyte
Details : Cynata plans to undertake a clinical trial of its Cymerus MSC product in patients with diabetic foot ulcers based on this solid pre-clinical foundation and utilising the TekCyte technology.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 01, 2021
Lead Product(s) : Cymerus mesenchymal stem cell
Therapeutic Area : Podiatry
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cymerus mesenchymal stem cells
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cymerus MSCs Demonstrate Efficacy in Preclinical Lung Disease Study
Details : Treatment with Cynata’s Cymerus MSCs led to statistically significant improvements in multiple harmful effects of IPF, including interstitial fibrosis, dynamic lung compliance and airway resistance.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
September 08, 2020
Lead Product(s) : Cymerus mesenchymal stem cells
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : MCA-derived mesenchymal stem cells
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cynata Completes Phase 1 GvHD Clinical Trial Follow-up with Positive Results
Details : The Phase 1 trial, which was the world’s first clinical trial of an allogeneic iPSC-derived MSC product, evaluated the safety and efficacy of CYP-001 for the treatment of patients with steroid-resistant acute graft-versus-host disease (GvHD).
Brand Name : CYP-001
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
July 30, 2020
Lead Product(s) : MCA-derived mesenchymal stem cells
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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