[{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Royalty Pharma","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2020","type":"Acquisition","leadProduct":"Ivacaftor","moa":"","graph1":"Genetic Disease","graph2":"Approved","graph3":"Cystic Fibrosis Foundation","amount2":0.65000000000000002,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0.65000000000000002,"dosageForm":"","sponsorNew":"Cystic Fibrosis Foundation \/ Royalty Pharma","highestDevelopmentStatusID":"12","companyTruncated":"Cystic Fibrosis Foundation \/ Royalty Pharma"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Calithera Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2020","type":"Funding","leadProduct":"CB-280","moa":"Arginase","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Cystic Fibrosis Foundation","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"6","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Beyond Air","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2021","type":"Funding","leadProduct":"Nitric Oxide","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Cystic Fibrosis Foundation","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"inhalation","sponsorNew":"Cystic Fibrosis Foundation \/ CF Foundation","highestDevelopmentStatusID":"10","companyTruncated":"Cystic Fibrosis Foundation \/ CF Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Microbion","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2021","type":"Funding","leadProduct":"Pravibismane","moa":"Microbial bioenergetic","graph1":"Infections and Infectious Diseases","graph2":"IND Enabling","graph3":"Cystic Fibrosis Foundation","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.01,"dosageForm":"inhalation","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"5","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Flagship Pioneering","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Undisclosed","year":"2021","type":"Partnership","leadProduct":"Undisclosed","moa":"","graph1":"Genetic Disease","graph2":"Discovery","graph3":"Cystic Fibrosis Foundation","amount2":0.11,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Genetic Disease","amount2New":0.11,"dosageForm":"Dosage Strength\/Form","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"2","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Pulmocide","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2021","type":"Funding","leadProduct":"Opelconazole","moa":"CYP51","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Cystic Fibrosis Foundation","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Suspension For Inhalation","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"8","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"BiomX","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Large molecule","year":"2022","type":"Funding","leadProduct":"BX004","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase I\/ Phase II","graph3":"Cystic Fibrosis Foundation","amount2":0.01,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.01,"dosageForm":"Inhalation","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"7","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Peptilogics","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Peptide","year":"2022","type":"Funding","leadProduct":"PLG0301","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Cystic Fibrosis Foundation","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"4","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Aridis Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2022","type":"Funding","leadProduct":"Gallium Citrate","moa":"","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Cystic Fibrosis Foundation","amount2":0.01,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0.01,"dosageForm":"Aerosol","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"8","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Anagram Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Large molecule","year":"2023","type":"Funding","leadProduct":"Enzyme-based Therapy","moa":"","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"Cystic Fibrosis Foundation","amount2":0.02,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0.02,"dosageForm":"Tablet","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"4","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Arcturus Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Large molecule","year":"2023","type":"Funding","leadProduct":"ARCT-032","moa":"","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Cystic Fibrosis Foundation","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0.029999999999999999,"dosageForm":"Aerosol (PMDI)","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"6","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"Cystic Fibrosis Foundation","sponsor":"Prime Medicine","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Funding","leadProduct":"Undisclosed","moa":"","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"Cystic Fibrosis Foundation","amount2":0.02,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0.02,"dosageForm":"","sponsorNew":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"4","companyTruncated":"Cystic Fibrosis Foundation \/ Cystic Fibrosis Foundation"}]

Find Clinical Drug Pipeline Developments & Deals by Cystic Fibrosis Foundation

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The net proceeds will be used to support the development of curative therapies by using Prime Editing to correct CFTR mutations at the natural genetic locus, for the treatment of Cystic Fibrosis (CF).

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 25, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Recipient : Prime Medicine

                          Deal Size : $15.0 million

                          Deal Type : Funding

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The funding will advance ARCT-032, a novel messenger RNA (mRNA) therapeutic candidate formulated with Arcturus’ LUNAR® delivery technology for the treatment of Cystic Fibrosis.

                          Brand Name : ARCT-032

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 26, 2023

                          Lead Product(s) : ARCT-032

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Recipient : Arcturus Therapeutics

                          Deal Size : $25.0 million

                          Deal Type : Funding

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : If the therapy is successful, people with CF would be able to decrease the number of enzyme pills they must take to digest food properly from a handful of pills to only one per meal.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 04, 2023

                          Lead Product(s) : Enzyme-based Therapy

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Recipient : Anagram Therapeutics

                          Deal Size : $15.5 million

                          Deal Type : Funding

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : AR-501 is a novel, small molecule and an inhalable form of gallium citrate, which acts as an iron analog to starve bacteria of iron. Gallium is believed to inhibit multiple iron-dependent synthetic and metabolic pathways required for pathogenicity.

                          Brand Name : AR-501

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 12, 2022

                          Lead Product(s) : Gallium Citrate

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Aridis Pharmaceuticals

                          Deal Size : $12.5 million

                          Deal Type : Funding

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : BiomX has been given grant to support a clinical trial of BX004, a phage therapy to fight Pseudomonas aeruginosa infections in people with cystic fibrosis (CF). In lab experiments conducted by BiomX, BX004 killed antibiotic-resistant strains of P. aerugi...

                          Brand Name : BX004

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 05, 2022

                          Lead Product(s) : BX004

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Recipient : BiomX

                          Deal Size : $5.0 million

                          Deal Type : Funding

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The award provided by the Cystic Fibrosis Foundation will generate both in vitro and in vivo data about PLG0301 and PLG0206, which may potentially support an Investigational New Drug (IND) application with the FDA for its continued development.

                          Brand Name : PLG0301

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          January 05, 2022

                          Lead Product(s) : PLG0301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : Peptilogics

                          Deal Size : Undisclosed

                          Deal Type : Funding

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The CF Foundation’s funding will support Phase 2 study of opelconazole. The objective of the study is to assess the safety and tolerability and patient’s ability to complete the course of treatment when used to prevent invasive pulmonary fungal infec...

                          Brand Name : PC945

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 06, 2021

                          Lead Product(s) : Opelconazole

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : Pulmocide

                          Deal Size : $3.5 million

                          Deal Type : Funding

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Pioneering Medicines and the Cystic Fibrosis Foundation will partner with multiple companies within the Flagship ecosystem, leveraging emerging technologies including Tessera Therapeutics’ Gene WritingTM technology, targeted delivery modalities, and RN...

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          November 03, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Discovery

                          Recipient : Flagship Pioneering

                          Deal Size : $110.0 million

                          Deal Type : Partnership

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : This new funding of up to $1.8 million will directly support IND-enabling toxicology studies of pravibismane and is in addition to $5.6 million previously awarded by the Foundation, for a combined total of up to $7.4 million.

                          Brand Name : MBN-101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 22, 2021

                          Lead Product(s) : Pravibismane

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Recipient : Microbion

                          Deal Size : $7.4 million

                          Deal Type : Funding

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The funding will support a clinical trial to determine whether high doses of inhaled nitric oxide are safe and effective when used in conjunction with current standard-of-care therapies, including amikacin and azithromycin.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 16, 2021

                          Lead Product(s) : Nitric Oxide,Amikacin,Azithromycin

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Undisclosed

                          Recipient : Beyond Air

                          Deal Size : $2.1 million

                          Deal Type : Funding

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