Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Recipient : Prime Medicine
Deal Size : $15.0 million
Deal Type : Funding
Prime Medicine Receives Up to $15 Million from Cystic Fibrosis Foundation
Details : The net proceeds will be used to support the development of curative therapies by using Prime Editing to correct CFTR mutations at the natural genetic locus, for the treatment of Cystic Fibrosis (CF).
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
January 25, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Recipient : Prime Medicine
Deal Size : $15.0 million
Deal Type : Funding
Lead Product(s) : ARCT-032
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Recipient : Arcturus Therapeutics
Deal Size : $25.0 million
Deal Type : Funding
Details : The funding will advance ARCT-032, a novel messenger RNA (mRNA) therapeutic candidate formulated with Arcturus’ LUNAR® delivery technology for the treatment of Cystic Fibrosis.
Brand Name : ARCT-032
Molecule Type : Large molecule
Upfront Cash : Undisclosed
September 26, 2023
Lead Product(s) : ARCT-032
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Recipient : Arcturus Therapeutics
Deal Size : $25.0 million
Deal Type : Funding
Lead Product(s) : Enzyme-based Therapy
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Recipient : Anagram Therapeutics
Deal Size : $15.5 million
Deal Type : Funding
Cystic Fibrosis Foundation Commits Up to $15.5M in Additional Funding for Potential Enzyme Therapy
Details : If the therapy is successful, people with CF would be able to decrease the number of enzyme pills they must take to digest food properly from a handful of pills to only one per meal.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Undisclosed
April 04, 2023
Lead Product(s) : Enzyme-based Therapy
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Recipient : Anagram Therapeutics
Deal Size : $15.5 million
Deal Type : Funding
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Recipient : Aridis Pharmaceuticals
Deal Size : $12.5 million
Deal Type : Funding
CF Foundation Invests Up to $4.85 Million in Aridis Pharmaceuticals for Testing of Anti-Infective
Details : AR-501 is a novel, small molecule and an inhalable form of gallium citrate, which acts as an iron analog to starve bacteria of iron. Gallium is believed to inhibit multiple iron-dependent synthetic and metabolic pathways required for pathogenicity.
Brand Name : AR-501
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 12, 2022
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Recipient : Aridis Pharmaceuticals
Deal Size : $12.5 million
Deal Type : Funding
Lead Product(s) : BX004
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I/ Phase II
Recipient : BiomX
Deal Size : $5.0 million
Deal Type : Funding
CFF Supporting Phase 1/2 Trial of Phage Therapy for P. aeruginosa Infections
Details : BiomX has been given grant to support a clinical trial of BX004, a phage therapy to fight Pseudomonas aeruginosa infections in people with cystic fibrosis (CF). In lab experiments conducted by BiomX, BX004 killed antibiotic-resistant strains of P. aerugi...
Brand Name : BX004
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 05, 2022
Lead Product(s) : BX004
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I/ Phase II
Recipient : BiomX
Deal Size : $5.0 million
Deal Type : Funding
Lead Product(s) : PLG0301
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Recipient : Peptilogics
Deal Size : Undisclosed
Deal Type : Funding
Details : The award provided by the Cystic Fibrosis Foundation will generate both in vitro and in vivo data about PLG0301 and PLG0206, which may potentially support an Investigational New Drug (IND) application with the FDA for its continued development.
Brand Name : PLG0301
Molecule Type : Peptide
Upfront Cash : Undisclosed
January 05, 2022
Lead Product(s) : PLG0301
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Recipient : Peptilogics
Deal Size : Undisclosed
Deal Type : Funding
Lead Product(s) : Opelconazole
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Recipient : Pulmocide
Deal Size : $3.5 million
Deal Type : Funding
Details : The CF Foundation’s funding will support Phase 2 study of opelconazole. The objective of the study is to assess the safety and tolerability and patient’s ability to complete the course of treatment when used to prevent invasive pulmonary fungal infec...
Brand Name : PC945
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 06, 2021
Lead Product(s) : Opelconazole
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Recipient : Pulmocide
Deal Size : $3.5 million
Deal Type : Funding
Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Study Phase : Discovery
Recipient : Flagship Pioneering
Deal Size : $110.0 million
Deal Type : Partnership
Details : Pioneering Medicines and the Cystic Fibrosis Foundation will partner with multiple companies within the Flagship ecosystem, leveraging emerging technologies including Tessera Therapeutics’ Gene WritingTM technology, targeted delivery modalities, and RN...
Brand Name : Undisclosed
Molecule Type : Undisclosed
Upfront Cash : Undisclosed
November 03, 2021
Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Highest Development Status : Discovery
Recipient : Flagship Pioneering
Deal Size : $110.0 million
Deal Type : Partnership
Lead Product(s) : Pravibismane
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Recipient : Microbion
Deal Size : $7.4 million
Deal Type : Funding
Details : This new funding of up to $1.8 million will directly support IND-enabling toxicology studies of pravibismane and is in addition to $5.6 million previously awarded by the Foundation, for a combined total of up to $7.4 million.
Brand Name : MBN-101
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 22, 2021
Lead Product(s) : Pravibismane
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Recipient : Microbion
Deal Size : $7.4 million
Deal Type : Funding
Lead Product(s) : Nitric Oxide,Amikacin,Azithromycin
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Undisclosed
Recipient : Beyond Air
Deal Size : $2.1 million
Deal Type : Funding
CF Foundation Awards Up to $2.17 Million to Beyond Air® to Develop Portable NTM Treatment
Details : The funding will support a clinical trial to determine whether high doses of inhaled nitric oxide are safe and effective when used in conjunction with current standard-of-care therapies, including amikacin and azithromycin.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 16, 2021
Lead Product(s) : Nitric Oxide,Amikacin,Azithromycin
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Undisclosed
Recipient : Beyond Air
Deal Size : $2.1 million
Deal Type : Funding
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