Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Zotatifin
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Effector Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
eFFECTOR and Dana-Farber to Evaluate Zotatifin in ER+ Endometrial Cancer
Details : The collaboration aims to conduct an investigator-sponsored trial evaluating zotatifin in patients with estrogen receptor-positive endometrial cancer and low-grade serous ovarian cancer.
Brand Name : eFT226
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 20, 2024
Lead Product(s) : Zotatifin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Effector Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : INV501
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Invios
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The collaboration aims to evaluate invIOs’ small molecule INV501 that can selectively enhance anti-tumor immune responses, as a potential treatment for glioblastoma.
Brand Name : INV501
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 09, 2023
Lead Product(s) : INV501
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Invios
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Cytokine Induced Memory-Like Natural Killer Cell,Nogapendekin alfa Inbakicept
Therapeutic Area : Oncology
Study Phase : Phase I
Recipient : ImmunityBio
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Anktiva™ (N-803 ), a lead cytokine fusion protein, is a novel IL-15 superagonist complex and which is investigated for advanced Head-and-Neck Cancer Patients.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
July 10, 2023
Lead Product(s) : Cytokine Induced Memory-Like Natural Killer Cell,Nogapendekin alfa Inbakicept
Therapeutic Area : Oncology
Highest Development Status : Phase I
Recipient : ImmunityBio
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : HSB-1216
Therapeutic Area : Oncology
Study Phase : IND Enabling
Recipient : Hillstream BioPharma
Deal Size : Undisclosed
Deal Type : Agreement
Details : Dana-Farber has granted under an exclusive option agreement to Hillstream Biopharma Inc., to develop anti-MUC1-C antibodies to selectively deliver Hillstream’s Quatramer-based lead candidate HSB-1216 targeting CSC by the induction of ferroptosis.
Brand Name : HSB-1216
Molecule Type : Small molecule
Upfront Cash : Undisclosed
January 31, 2023
Lead Product(s) : HSB-1216
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Recipient : Hillstream BioPharma
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Study Phase : Phase II
Recipient : EpicentRx
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : RRx-001 leads EpicentRx's CyNRGY platform as a first-in-class investigational treatment sourced from an exclusively licensed portfolio of aerospace-derived small molecules.
Brand Name : RRx-001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 01, 2022
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Highest Development Status : Phase II
Recipient : EpicentRx
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KP1237,Autologous Cytokine Induced Memory-Like NK Cell
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Recipient : Biohaven Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BHV-1100 targets the destruction of CD38-expressing cells in combination with autologous cytokine induced memory-like (CIML) natural killer (NK) cells and immune globulin (Ig) in multiple myeloma patients undergoing autologous stem cell transplant.
Brand Name : BHV-1100
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 27, 2021
Lead Product(s) : KP1237,Autologous Cytokine Induced Memory-Like NK Cell
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Recipient : Biohaven Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Nirogacestat Hydrobromide,Anti-B-cell Maturation Antigen
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : SpringWorks Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The collaboration is designed to further investigate nirogacestat, SpringWorks’ investigational gamma-secretase inhibitor (GSI), with anti-B-cell maturation antigen (BCMA) agents in a variety of preclinical multiple myeloma models.
Brand Name : PF-03084014
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 30, 2021
Lead Product(s) : Nirogacestat Hydrobromide,Anti-B-cell Maturation Antigen
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : SpringWorks Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Dana-Farber Receives $50 million Funding to Study Pancreatic Cancer
Details : Funding will enable a wide range of ambitious work in two main areas of pancreatic cancer research: early detection and prevention, and precision medicine and biology.
Brand Name : Undisclosed
Molecule Type : Undisclosed
Upfront Cash : Undisclosed
May 11, 2021
Lead Product(s) : Autologous MSC-NTF cells
Therapeutic Area : Neurology
Study Phase : Phase III
Recipient : BrainStorm Cell Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Through the newly announced EAP, the six clinical centers of excellence participating in the Phase 3 NurOwn® trial will each have the opportunity to treat ALS patients who completed the trial.
Brand Name : NurOwn
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 14, 2020
Lead Product(s) : Autologous MSC-NTF cells
Therapeutic Area : Neurology
Highest Development Status : Phase III
Recipient : BrainStorm Cell Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Axicabtagene Ciloleucel,Fludarabine Phosphate,Cyclophosphamide
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
CAR T-Cell Therapy Found Highly Effective in Patients with High-Risk Non-Hodgkin Lymphoma
Details : In the current trial, dubbed ZUMA-5, investigators administered axi-cel to 146 patients with follicular lymphoma or marginal zone lymphoma-two slow-growing forms of non-Hodgkin leukemia-at multiple U.S. medical centers.
Brand Name : Yescarta
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 05, 2020
Lead Product(s) : Axicabtagene Ciloleucel,Fludarabine Phosphate,Cyclophosphamide
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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