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    [{"orgOrder":0,"company":"Alpine Immune Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Davoceticept","moa":"CD28","graph1":"Oncology","graph2":"Phase I","graph3":"Alpine Immune Sciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Alpine Immune Sciences \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Alpine Immune Sciences \/ Not Applicable"},{"orgOrder":0,"company":"Alpine Immune Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Davoceticept","moa":"CD28","graph1":"Oncology","graph2":"Phase I","graph3":"Alpine Immune 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Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Alpine Immune Sciences \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals for Davoceticept

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                            01

                            Alpine Immune Sciences

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                            Alpine Immune Sciences

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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Terminates Enrollment of Davoceticept Clinical Studies (NEON-1 and NEON-2)

                            Details : Decision to terminate enrollment in davoceticept (ALPN-202) conditional CD28 costimulator and dual checkpoint inhibitor studies was made in interest of patient safety after the Company was notified of a second death in the NEON-2 study, attributed to car...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 24, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces R&D Day to Provide Clinical Updates on Wholly-Owned Programs ALPN-303 and Dav...

                            Details : ALPN-303, a best-in-class dual B cell cytokine antagonist being developed for the treatment of B cell mediated inflammatory and autoimmune diseases, and davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor for the treatm...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 30, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces Presentations at the 2022 EULAR and ASCO Annual Meetings

                            Details : Davoceticept (ALPN-202) , first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have successfully demonstrated superior efficacy in tumor models compared to check...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 26, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces FDA Removes Partial Clinical Hold on NEON-2 Clinical Trial of Davoceticept (A...

                            Details : Davoceticept (ALPN-202) is first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have demonstrated superior efficacy in tumor models compared to checkpoint inhibi...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 24, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed

                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Publishes Key Preclinical Rationale for Davoceticept (ALPN-202), a First-in-Class CD28 ...

                            Details : ALPN-202 (Davoceticept), a first-in-class, CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhib...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 04, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces Oral Presentation at the 2022 AACR Annual Meeting

                            Details : ALPN-202 (davoceticept), a first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor is engineered to provide direct T cell costimulation and dual checkpoint inhibition to enable immune system to mount a robust anti-tumor response.

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 08, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed

                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Reports FDA Partial Clinical Hold on NEON-2 Trial of Davoceticept (ALPN-202) in Combina...

                            Details : The partial clinical hold was prompted by Alpine’s report of a Grade 5 serious adverse event in the NEON-2 trial, evaluating davoceticept (ALPN-202) in combination with pembrolizumab in adults with advanced malignancies.

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 07, 2022

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Merck & Co

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                            Antibody Engineering
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                            Merck & Co

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                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Alpine Immune Sciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences to Collaborate with Merck on Immuno-Oncology Study to Evaluate ALPN-202 in Combination ...

                            Details : The collaboration will evaluate the safety and efficacy of Alpine’s ALPN-202, a first-in-class conditional CD28 costimulator and dual checkpoint inhibitor, in combination with Merck’s anti-PD-1 therapy KEYTRUDA, the first anti-PD-1 therapy approved i...

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            June 30, 2021

                            Lead Product(s) : Davoceticept,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Alpine Immune Sciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            09

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Davoceticept

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces ALPN-202 Clinical Data Presented at the 2021 ASCO Virtual Annual Meeting

                            Details : ALPN-202 has been generally well-tolerated as of the data cutoff date. The most common treatment-related adverse events have included immune-related toxicities, particularly cutaneous reactions.

                            Brand Name : ALPN-202

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 04, 2021

                            Lead Product(s) : Davoceticept

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Alpine Immune Sciences

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                            Antibody Engineering
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                            Lead Product(s) : Davoceticept

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alpine Immune Sciences Announces ALPN-202 Poster Presentation at AACR Virtual Annual Meeting II

                            Details : Preclinical studies of ALPN-202 have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone. A phase 1 trial of ALPN-202 in advanced malignancies (NEON-1, NCT04186637) is open for enrollment.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 15, 2020

                            Lead Product(s) : Davoceticept

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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