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Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Dexamethasone","moa":"||CD-38","graph1":"Oncology","graph2":"Phase II","graph3":"I-Mab Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"I-Mab Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"I-Mab Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Amneal Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Steroid","year":"2021","type":"Inapplicable","leadProduct":"Dexamethasone","moa":"Glucocorticoid receptor","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Approved FDF","graph3":"Amneal 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Defense"},{"orgOrder":0,"company":"SpineThera","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Steroid","year":"2023","type":"Inapplicable","leadProduct":"Dexamethasone","moa":"Glucocorticoid receptor","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"SpineThera","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Epidural Injection","sponsorNew":"SpineThera \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"SpineThera \/ Inapplicable"}]

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                          01

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Sarclisa (isatuximab) is the first anti-CD38 therapy in combination with pomalidomide and Dexamethasone treatment for adult patients with multiple myeloma.

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 13, 2025

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Sarclisa (isatuximab) is the first anti-CD38 therapy in combination with pomalidomide and Dexamethasone treatment for adult patients with elapsed or refractory multiple myeloma.

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Details : ODM-208/MK5684, a CYP11A1 inhibitor, is in Phase 3 trials for metastatic castration-resistant prostate cancer with hormone replacement.

                          Product Name : ODM-208

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 01, 2024

                          Lead Product(s) : Opevesostat,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Fermion Orion Company Banner

                          04

                          Details : Through the license agreement, Merck will gain global rights to develop and commercialize MK-5684 (opevesostat), which is being evaluated for metastatic castration-resistant prostate cancer.

                          Product Name : MK-5684

                          Product Type : Other Small Molecule

                          Upfront Cash : $290.0 million

                          January 07, 2024

                          Lead Product(s) : Opevesostat,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : $1,920.0 million

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          05

                          Details : ODM-208 (or MK-5684) is an investigational oral, non-steroidal and selective inhibitor of the CYP11A1 enzyme discovered and developed by Orion for the treatment of hormone-dependent cancers, such as metastatic castration-resistant prostate cancer.

                          Product Name : ODM-208

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 21, 2023

                          Lead Product(s) : Opevesostat,Dexamethasone,Hydrocortisone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Fermion Orion Company Banner

                          06

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Sarclisa (isatuximab) is a antibody that binds to a specific epitope on the CD38 receptor on multiple myeloma (MM) cells. It is being evaluated in phase 3 clinical trials in combination with carfilzomib, lenalidomide & dexamethasone (KRd) for the treatme...

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          November 12, 2023

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          07

                          Details : NICE recommends Ozurdex® (dexamethasone) as an option for treating visual impairment caused by DMO in adults, only when it has not responded well enough to, or they cannot have non-corticosteroid therapy.

                          Product Name : Ozurdex

                          Product Type : Steroid

                          Upfront Cash : Inapplicable

                          November 08, 2022

                          Lead Product(s) : Dexamethasone

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          08

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Latest results from Phase 3 IKEMA clinical trial for Sarclisa®(isatuximab-irfc) in combination with carfilzomib and dexamethasone demonstrated a median PFS of 35.7 months, compared to 19.2 months in patients treated with Kd alone.

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 15, 2022

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          09

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Details : For the Sarclisa® subcutaneous formulation delivery, Sanofi has partnered with drug delivery technology innovator company to advance the development of a subcutaneous delivery for Sarclisa® with the goal of offering a unique patient-centric treatment e...

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          March 15, 2022

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Sanofi Company Banner

                          10

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SARCLISA® continues to be evaluated in multiple ongoing Phase 3 clinical trials in combination with current standard treatments across the MM treatment continuum. It is also under investigation for the treatment of other hematologic malignancies and sol...

                          Product Name : Sarclisa

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 13, 2021

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner