Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Ascletis Completes ASC40 Phase III Trial Enrollment for Acne
Details : ASC40 (Denifanstat) is a FASN inhibitor small molecule drug candidate, which is currently being evaluated for the treatment of acne vulgaris via oral tablet.
Brand Name : ASC40
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 12, 2024
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sagimet Receives FDA Breakthrough Therapy Designation for Denifanstat in MASH
Details : TVB-264 (denifanstat) is a selective FASN inhibitor, which is under clinical development for the treatment of metabolic dysfunction-associated steatohepatitis/Non-alcoholic Steatohepatitis.
Brand Name : TVB-2640
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 01, 2024
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sagimet Completes Phase 1 Hepatic Impairment Study of FASN Inhibitor Denifanstat
Details : TVB-264 (denifanstat) is a selective FASN inhibitor, which is under clinical development for the treatment of metabolic dysfunction-associated steatohepatitis/Non-alcoholic Steatohepatitis.
Brand Name : TVB-2640
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 27, 2024
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sagimet Announces Positive Results from Phase 2b of Denifanstat in F2/F3 NASH
Details : TVB-2640 (denifanstat) is an orally bioavailable fatty acid synthase (FASN) inhibitor. It is being evaluated in phase 2 clinical trials for the treatment of Nonalcoholic Fatty Liver Disease.
Brand Name : TVB-2640
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 23, 2024
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Gannex's Partner Sagimet Announces Positive Results From Phase 2b Trial Of Denifanstat
Details : TVB-2640 (denifanstat) is an oral, selective FASN inhibitor which is under phase 2 clinical development for the treatment of non-alcoholic steatohepatitis patients with stage 2 or stage 3 fibrosis.
Brand Name : TVB-2640
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 22, 2024
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ASC40 (Denifanstat) is a FASN inhibitor small molecule drug candidate, which is currently being evaluated for the treatment of acne vulgaris via oral tablet.
Brand Name : ASC40
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 05, 2023
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat,Bevacizumab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Ascletis Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ASC40 (denifanstat) is an oral, selective small molecule inhibitor of fatty acid synthase (FASN). It is being investigated in combined with bevacizumab for the treatment of recurrent glioblastoma.
Brand Name : ASC40
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 27, 2023
Lead Product(s) : Denifanstat,Bevacizumab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Ascletis Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ASC40 (denifanstat) is an oral, selective small molecule inhibitor of fatty acid synthase (FASN). It is being investigated for the treatment of mild-moderate acne vulgaris.
Brand Name : ASC40
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 02, 2023
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ASC40 (denifanstat) is an oral, selective small molecule inhibitor of fatty acid synthase (FASN), a key enzyme which regulates DNL. Human sebum production requires de novo lipogenesis, which is increased in acne and can be suppressed by the FASN inhibito...
Brand Name : ASC40
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 30, 2022
Lead Product(s) : Denifanstat
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Denifanstat (TVB-2640) is an oral, selective, first-in-class fatty acid synthase inhibitor that directly targets the primary drivers of NASH by reducing excess liver fat (steatosis), decreasing inflammation and blunting fibrosis.
Brand Name : TVB-2640
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 03, 2022
Lead Product(s) : Denifanstat
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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