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    [{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Rumpus Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Licensing Agreement","leadProduct":"Enzastaurin","moa":"PKC beta","graph1":"Oncology","graph2":"Phase III","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Denovo Biopharma \/ Rumpus Therapeutics","highestDevelopmentStatusID":"10","companyTruncated":"Denovo Biopharma \/ Rumpus Therapeutics"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Forte Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Acquisition","leadProduct":"Vocimagene amiretrorepvec","moa":"","graph1":"Oncology","graph2":"Discovery","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Denovo Biopharma \/ Denovo Biopharma","highestDevelopmentStatusID":"2","companyTruncated":"Denovo Biopharma \/ Denovo Biopharma"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Enzastaurin","moa":"PKC beta","graph1":"Oncology","graph2":"Phase III","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Denovo Biopharma \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Denovo Biopharma \/ Not Applicable"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Jiangsu Wuzhong Pharmaceutical Group","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Acquisition","leadProduct":"Endostatin","moa":"VEGF","graph1":"Oncology","graph2":"Phase III","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Denovo Biopharma \/ Denovo Biopharma","highestDevelopmentStatusID":"10","companyTruncated":"Denovo Biopharma \/ Denovo Biopharma"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Aytu BioScience","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2021","type":"Licensing Agreement","leadProduct":"Enzastaurin","moa":"PKC beta","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral","sponsorNew":"Denovo Biopharma \/ Aytu BioPharma","highestDevelopmentStatusID":"4","companyTruncated":"Denovo Biopharma \/ Aytu BioPharma"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"H. 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    Find Clinical Drug Pipeline Developments & Deals by Denovo Biopharma

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                            01

                            Denovo Biopharma

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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Grants Fast Track For DB104 in Treatment-Resistant Depression

                            Details : DB104 (liafensine) is a first–in–class triple reuptake inhibitor. It is being evaluated for the treatment of patients with treatment-resistant depression.

                            Brand Name : DB104

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 09, 2024

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            Lead Product(s) : Vocimagene Amiretrorepvec,Fluocytosine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : California Institute for Regenerative Medicine

                            Deal Size : $11.8 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Cirm Awards $11.8 Million Grant for Trial in High-Grade Glioma Using DB107

                            Details : The proceeds will advance the development of DB107, consisting of two components: DB107–RRV as a prodrug activator and DB107–FC as an oral prodrug for high-grade glioma, including glioblastoma.

                            Brand Name : DB107-RRV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 30, 2024

                            Lead Product(s) : Vocimagene Amiretrorepvec,Fluocytosine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : California Institute for Regenerative Medicine

                            Deal Size : $11.8 million

                            Deal Type : Funding

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                            03

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Denovo Biopharma Announces Breakthrough in Treatment-Resistant Depression

                            Details : DB104 (liafensine) is a first-in-class triple reuptake inhibitor targeting serotonin, norepinephrine, and dopamine transporters, being studied for treatment-resistant depression.

                            Brand Name : DB104

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 03, 2024

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            Lead Product(s) : Vocimagene Amiretrorepvec,Fluocytosine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            United States Food and Drug Administration (FDA) Authorizes Phase 2 Study of DB107 In Promising Turn-Around of...

                            Details : DB107 (vocimagene amiretrorepvec) is a two-part cancer-selective immunotherapy comprising an investigational gene therapy treatment and an investigational small molecule, which is investigated for the treatment of newly diagnosed high grade glioma.

                            Brand Name : DB107

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 25, 2023

                            Lead Product(s) : Vocimagene Amiretrorepvec,Fluocytosine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Curia

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            First Patient Dosed in the ENLIGHTEN Biomarker-Guided Global Clinical Trial of DB104 (Liafensine) for Treatmen...

                            Details : Denovo discovered a novel genetic biomarker for DB104 (liafensine) efficacy using its unique machine learning approach with whole genome sequencing to identify biomarkers that may be predictive of a patient's response to a specific medicine.

                            Brand Name : DB104

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 28, 2022

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Curia

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            Lead Product(s) : Enzastaurin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Qiagen

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            QIAGEN and Denovo Biopharma Partner to Develop Companion Diagnostic Test for the Treatment of Diffuse Large B-...

                            Details : Under the agreement, QIAGEN will develop a diagnostic assay that can detect the Denovo Genomic Marker 1 (DGM1) in DLBCL patients, a biomarker discovered by Denovo that predicts the responsiveness to DB102, also known as enzastaurin.

                            Brand Name : Kinenza

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 09, 2021

                            Lead Product(s) : Enzastaurin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Qiagen

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            07

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Lead Product(s) : Idalopirdine

                            Therapeutic Area : Neurology

                            Study Phase : Phase III

                            Recipient : H. Lundbeck AS

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Denovo Biopharma In-Licenses Late-Stage Alzheimer's Disease Asset from Lundbeck

                            Details : Lundbeck gets options to re-acquire idalopirdine for predetermined undisclosed financial terms, with Denovo and Lundbeck sharing China rights in the event Lundbeck's options are exercised and Denovo retaining all global rights in the event Lundbeck's opt...

                            Brand Name : DB109

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            July 01, 2021

                            Lead Product(s) : Idalopirdine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase III

                            Recipient : H. Lundbeck AS

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Lead Product(s) : Enzastaurin

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Aytu BioScience

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Denovo's Licenses DB102 (Enzastaurin) for Rare Genetic Pediatric Onset Disorders to Aytu BioPharma

                            Details : Aytu BioPharma has acquired substantially all the assets of Rumpus Therapeutics, including Rumpus' option to license DB102 for rare genetic pediatric onset or congenital disorders outside of oncology from Denovo Biopharma LLC.

                            Brand Name : DB102

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            April 13, 2021

                            Lead Product(s) : Enzastaurin

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Aytu BioScience

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            Denovo Biopharma

                            U.S.A arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Denovo Biopharma

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                            Lead Product(s) : Endostatin

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Jiangsu Wuzhong Pharmaceutical Group

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Denovo Biopharma Acquires a Novel Late-Stage Oncology Drug and Expands into Protein Therapeutics

                            Details : DB108 is a recombinant protein drug that inhibits tumor growth and metastasis by inhibiting angiogenesis. Denovo gains global rights (except China) to develop, manufacture and commercialize endostatin from Jiangsu Wuzhong Pharmaceutical Group Corporation...

                            Brand Name : DB108

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 10, 2020

                            Lead Product(s) : Endostatin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Jiangsu Wuzhong Pharmaceutical Group

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            10

                            Denovo Biopharma

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                            euroPLX 86 Munich
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                            Denovo Biopharma

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                            Lead Product(s) : Enzastaurin,Temozolomide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Grants Fast Track Designation For DB102 in Patients with Newly-Diagnosed Glioblastoma (GBM)

                            Details : Denovo plans to conduct a randomized, double-blind, placebo-controlled Phase 3 pivotal study of enzastaurin in combination with temozolomide, both during and following radiation therapy, in newly-diagnosed glioblastoma patients.

                            Brand Name : Kinenza

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 17, 2020

                            Lead Product(s) : Enzastaurin,Temozolomide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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