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Biologics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Protein","year":"2025","type":"Inapplicable","leadProduct":"HCW9302","moa":"IL-2R","graph1":"Dermatology","graph2":"IND Enabling","graph3":"HCW Biologics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"HCW Biologics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"HCW Biologics \/ Inapplicable"},{"orgOrder":0,"company":"Alys Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Inapplicable","leadProduct":"JAK1 siRNA-lipid Conjugate","moa":"JAK1","graph1":"Dermatology","graph2":"IND Enabling","graph3":"Alys Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Intradermal Injection","sponsorNew":"Alys Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Alys Pharmaceuticals \/ Inapplicable"}]

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                          01

                          BIO CEO & Investor
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                          Details : ALY-101 is an intradermal injectable JAK1 siRNA-lipid conjugate being investigated in patients suffering from Alopecia Areata (AA).

                          Product Name : ALY-101

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 04, 2025

                          Lead Product(s) : JAK1 siRNA-lipid Conjugate

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : HCW9302 is an injectable, first-in-kind interleukin 2 fusion protein complex, which is being evaluated in patients with moderate-to-severe alopecia areata.

                          Product Name : HCW9302

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          February 03, 2025

                          Lead Product(s) : HCW9302

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : ORKA-001 is a IL-23p19 inhibitor, antibody. It is currently being evaluated in early-stage clinical trials for the treatment of psoriasis.

                          Product Name : Undisclosed

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          December 19, 2024

                          Lead Product(s) : ORKA-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : STAR-0310 is an OX40 inhibitor monoclonal antibody candidate, which is currently being evaluated for the treatment of patients with atopic dermatitis.

                          Product Name : Undisclosed

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          December 10, 2024

                          Lead Product(s) : STAR-0310

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : The proceeds will be used to advance TRexBio’s TRB-061, a purpose-engineered TNFR2 agonist, in patients with immune mediated diseases including atopic dermatitis and ulcerative colitis.

                          Product Name : TRB-061

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 13, 2024

                          Lead Product(s) : TRB-061

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Delos Capital

                          Deal Size : $84.0 million

                          Deal Type : Series B Financing

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                          06

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : RLS-1496 is a topically administered therapeutic, and the Phase 1 study will include patients with skin conditions to test safety in primary endpoints.

                          Product Name : RLS-1496

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 23, 2024

                          Lead Product(s) : RLS-1496

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : KT-621 is an investigational first-in-class once daily, oral STAT6 degrader. Currently;y, it is being evaluated for treating Atopic Dermatitis and Asthma.

                          Product Name : KT-621

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 09, 2024

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : The net proceeds from the financing will be used to support the clinical development of ORKA-001, currently being evaluated in early-stage clinical trials for the treatment of psoriasis.

                          Product Name : ORKA-001

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 12, 2024

                          Lead Product(s) : ORKA-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Braidwell LP

                          Deal Size : $200.0 million

                          Deal Type : Private Placement

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                          09

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Through the merger, the company will focus on advancing Oruka’s pipeline of potentially best-in-class biologics, including ORKA-001 (an IL-23p19 inhibitor) for the treatment of plaque psoriasis.

                          Product Name : ORKA-001

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 29, 2024

                          Lead Product(s) : ORKA-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Oruka Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          10

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : The study evaluated the immunological inhibitory effects of the topical application of Turn Therapeutics' candidate, GX-03, in an eczema model using C57BL/6 mice.

                          Product Name : GX-03

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 05, 2024

                          Lead Product(s) : GX-03

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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