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therapy","year":"2020","type":"Inapplicable","leadProduct":"HST 001","moa":"Undisclosed","graph1":"Dermatology","graph2":"Phase I\/ Phase II","graph3":"Histogen","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Intradermal Injection","sponsorNew":"Histogen \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Histogen \/ Inapplicable"},{"orgOrder":0,"company":"Artax Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"AX-158","moa":"Nck-SH3.1 domain","graph1":"Dermatology","graph2":"Phase I\/ Phase II","graph3":"Artax Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Artax Biopharma \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Artax Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Inmagene Biopharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"IMG-007","moa":"OX40 receptor","graph1":"Dermatology","graph2":"Phase I\/ Phase II","graph3":"Inmagene Biopharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Inmagene Biopharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Inmagene Biopharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"BEN-2293","moa":"TRK","graph1":"Dermatology","graph2":"Phase I\/ Phase II","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Ointment","sponsorNew":"BenevolentAI \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BenevolentAI \/ Inapplicable"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"BEN-2293","moa":"TRK","graph1":"Dermatology","graph2":"Phase I\/ Phase II","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Ointment","sponsorNew":"BenevolentAI \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BenevolentAI \/ Inapplicable"}]

Find Dermatology Drugs in Phase I/II Clinical Development

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : AX-158 is a first-in-class, oral, Nck modulator, small molecule drug candidate, which is currently being evaluated for the treatment of mild to moderate plaque psoriasis.

                          Product Name : AX-158

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 22, 2025

                          Lead Product(s) : AX-158

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : IMG-007 is a monoclonal antibody (mAb) targeting OX40, currently being investigated for the treatment of atopic dermatitis.

                          Product Name : IMG-007

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : IMG-007

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : Through the merger, the combined company will prioritize the development of IMG-007, a monoclonal antibody (mAb) targeting OX40, for the treatment of atopic dermatitis.

                          Product Name : IMG-007

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          December 23, 2024

                          Lead Product(s) : IMG-007

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Ikena Oncology

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          04

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : The financing aims to support the advancement of the Siolta clinical program STMC-103H, which is being evaluated in Phase I/II clinical trial studies for Atopic Dermatitis and Type 1 Hypersensitivity.

                          Product Name : STMC-103H

                          Product Type : Microorganism

                          Upfront Cash : Undisclosed

                          December 03, 2024

                          Lead Product(s) : STMC-103H

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : SymBiosis and Khosla Ventures

                          Deal Size : $12.0 million

                          Deal Type : Series C Financing

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                          05

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : JSP191 (briquilimab) is a novel antibody therapy targeting c-Kit (CD117). It is being evaluated as a conditioning agent in the treatment of chronic spontaneous urticaria & chronic inducible urticaria.

                          Product Name : JSP191

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 23, 2024

                          Lead Product(s) : Briquilimab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : JSP191 (briquilimab) is a novel antibody therapy targeting c-Kit (CD117). It is being evaluated as a conditioning agent in the treatment of chronic spontaneous urticaria & chronic inducible urticaria.

                          Product Name : JSP191

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 14, 2024

                          Lead Product(s) : Briquilimab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : ATR-04 is a live biotherapeutic product candidate including an isolated, naturally derived Staphylococcus epidermidis strain. It is being evaluated for the treatment of EGFRi-associated skin rash.

                          Product Name : ATR-04

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          September 18, 2024

                          Lead Product(s) : Recombinant Staphylococcus Epidermidis

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : ATR-04 is a live biotherapeutic product candidate including an isolated, naturally derived Staphylococcus epidermidis strain. It is being evaluated for the treatment of EGFRi-associated skin rash.

                          Product Name : ATR-04

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          August 22, 2024

                          Lead Product(s) : Recombinant Staphylococcus Epidermidis

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : IMG-007 is a humanized anti-OX40 IgG1 mAb, with a silenced ADCC function and an extended half-life. It is designed to target immunological diseases like atopic dermatitis.

                          Product Name : IMG-007

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          June 05, 2024

                          Lead Product(s) : IMG-007

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : JSP191 (briquilimab) is a novel antibody targeting c-Kit (CD117) for mast cell diseases. It is being evaluated as a conditioning agent in treating chronic spontaneous and inducible urticaria.

                          Product Name : JSP191

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 19, 2024

                          Lead Product(s) : Briquilimab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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