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AstraZeneca"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Daiichi Sankyo","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Deruxtecan","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"AstraZeneca \/ Daiichi Sankyo","highestDevelopmentStatusID":"8","companyTruncated":"AstraZeneca \/ Daiichi Sankyo"}]

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                          01

                          Antibody Engineering
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                          Antibody Engineering
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                          Details : Enhertu (trastuzumab deruxtecan) is a HER2-directed antibody-drug conjugate in phase 3 trials for treating patients with unresectable or metastatic HER2-expressing tumors.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 29, 2024

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Daiichi Sankyo

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate and received EU approval for Patients with HER2 Mutant Advanced Non-Small Cell Lung Cancer.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 23, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : AstraZeneca

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki in the U.S. only) is a HER2 directed ADC, which has been recommended for approval in the European Union (EU) as a monotherapy for the treatment of adult patients with advanced non-small cel...

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 15, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : AstraZeneca

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate and received two additional Breakthrough Therapy Designations (BTDs) in the U.S. for the treatment of HER2 positive solid tumors.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 31, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : AstraZeneca

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate and approved in Japan as first HER2 directed therapy for patients with HER2 mutant metastatic non-small cell lung cancer.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 23, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ENHERTU (Trastuzumab deruxtecan) is a HER2 directed antibody drug conjugate (ADC) attached to a topoisomerase I inhibitor payload, via a stable tetrapeptide-based cleavable linker, being developed for multiple HER2-expressing advanced solid tumours.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 27, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Daiichi Sankyo

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ENHERTU (Trastuzumab deruxtecan) is a HER2 directed antibody drug conjugate (ADC) attached to a topoisomerase I inhibitor payload, via a stable tetrapeptide-based cleavable linker. Drug is used as a HER2 Low Metastatic Breast Cancer.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 12, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate. Company has received approval from the DCGI to import the cancer drug trastuzumab deruxtecan used for the treatment of metastatic breast cancer.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 03, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Daiichi Sankyo

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate. It binds to HER2 on tumor cells and undergoes internalization and intracellular linker cleavage by lysosomal enzymes. Thus causing DNA damage and apoptotic cell death.

                          Brand Name : ENHERTU

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          March 06, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : AstraZeneca

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Enhertu (fam-trastuzumab deruxtecan-nxki) is a HER2-directed antibody-drug conjugate. It binds to HER2 on tumor cells and undergoes internalization and intracellular linker cleavage by lysosomal enzymes. Thus causing DNA damage and apoptotic cell death.

                          Brand Name : Enhertu

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          March 06, 2023

                          Lead Product(s) : Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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