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Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"CFT7455","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"C4 Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"C4 Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"C4 Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Sanofi","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Dexamethasone","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Sanofi","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Sanofi \/ Not 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Hoffmann-La Roche \/ Not Applicable"},{"orgOrder":0,"company":"GSK","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Belantamab Mafodotin","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"GSK","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"GSK \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"GSK \/ Not Applicable"},{"orgOrder":0,"company":"Orion Corporation","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Licensing Agreement","leadProduct":"Opevesostat","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Orion Corporation","amount2":1.9199999999999999,"highestDevelopmentShortName":"Ph 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                          01

                          Details : Through the license agreement, Merck will gain global rights to develop and commercialize MK-5684 (opevesostat), which is being evaluated for metastatic castration-resistant prostate cancer.

                          Brand Name : MK-5684

                          Molecule Type : Small molecule

                          Upfront Cash : $290.0 million

                          July 01, 2024

                          Lead Product(s) : Opevesostat,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : $1,920.0 million

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          02

                          Details : ODM-208/MK5684, a CYP11A1 inhibitor, is in Phase 3 trials for metastatic castration-resistant prostate cancer with hormone replacement.

                          Brand Name : ODM-208

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 05, 2024

                          Lead Product(s) : MK5684,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          03

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Sarclisa (isatuximab) is a antibody that binds to a specific epitope on the CD38 receptor on multiple myeloma (MM) cells. It is being evaluated in phase 3 clinical trials in combination with carfilzomib, lenalidomide & dexamethasone (KRd) for the treatme...

                          Brand Name : Sarclisa

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          December 11, 2023

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          04

                          Details : ODM-208 (or MK-5684) is an investigational oral, non-steroidal and selective inhibitor of the CYP11A1 enzyme discovered and developed by Orion for the treatment of hormone-dependent cancers, such as metastatic castration-resistant prostate cancer.

                          Brand Name : ODM-208

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 21, 2023

                          Lead Product(s) : MK-5684,Dexamethasone,Hydrocortisone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          05

                          Details : NICE recommends Ozurdex® (dexamethasone) as an option for treating visual impairment caused by DMO in adults, only when it has not responded well enough to, or they cannot have non-corticosteroid therapy.

                          Brand Name : Ozurdex

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 11, 2022

                          Lead Product(s) : Dexamethasone

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          06

                          Lead Product(s) : Isatuximab-irfc,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Latest results from Phase 3 IKEMA clinical trial for Sarclisa®(isatuximab-irfc) in combination with carfilzomib and dexamethasone demonstrated a median PFS of 35.7 months, compared to 19.2 months in patients treated with Kd alone.

                          Brand Name : Sarclisa

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 15, 2022

                          Lead Product(s) : Isatuximab-irfc,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          07

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Details : For the Sarclisa® subcutaneous formulation delivery, Sanofi has partnered with drug delivery technology innovator company to advance the development of a subcutaneous delivery for Sarclisa® with the goal of offering a unique patient-centric treatment e...

                          Brand Name : Sarclisa

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          March 15, 2022

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Sanofi Company Banner

                          08

                          Lead Product(s) : Isatuximab-irfc,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : SARCLISA® continues to be evaluated in multiple ongoing Phase 3 clinical trials in combination with current standard treatments across the MM treatment continuum. It is also under investigation for the treatment of other hematologic malignancies and sol...

                          Brand Name : Sarclisa

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 13, 2021

                          Lead Product(s) : Isatuximab-irfc,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          09

                          Lead Product(s) : Lenalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Reddy-Lenalidomide capsules are available in 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg strengths, each in blister packs.

                          Brand Name : Revlimid

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 02, 2021

                          Lead Product(s) : Lenalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Dr Reddy Company Banner

                          10

                          Details : Kyprolis-Generic (carfilzomib) is a proteasome inhibitor, small molecule drug candidate, which is indicated for the treatment of patients with relapsed or refractory multiple myeloma as monotherapy or in combination with dexamethasone or with lenalidomid...

                          Brand Name : Kyprolis-Generic

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          June 16, 2021

                          Lead Product(s) : Carfilzomib,Lenalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Breckenridge Pharmaceutical