Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : SVB Securities
Deal Size : $225.0 million
Deal Type : Public Offering
Axsome Therapeutics Announces Closing of Public Offering of $225 Million of Shares of Common Stock
Details : Axsome intends to use the proceeds to advance its late-stage pipeline, including AXS-05 (dextromethorphan-bupropion), a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed for the treatment of central nervous sy...
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 30, 2023
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : SVB Securities
Deal Size : $225.0 million
Deal Type : Public Offering
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : SVB Securities
Deal Size : $225.0 million
Deal Type : Public Offering
Axsome Therapeutics Announces Pricing of Public Offering of $225 Million of Shares of Common Stock
Details : Axsome intends to use the proceeds to advance its late-stage pipeline, including AXS-05 (dextromethorphan-bupropion), a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed for the treatment of central nervous sy...
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 28, 2023
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : SVB Securities
Deal Size : $225.0 million
Deal Type : Public Offering
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : SVB Securities
Deal Size : Undisclosed
Deal Type : Public Offering
Axsome Therapeutics Announces Proposed Public Offering of Common Stock
Details : Axsome intends to use the proceeds to advance its late-stage pipeline, including AXS-05 (dextromethorphan), a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed for the treatment of central nervous system condi...
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 27, 2023
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : SVB Securities
Deal Size : Undisclosed
Deal Type : Public Offering
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AXS-05 (dextromethorphan-bupropion) is novel, oral, patent protected, investigational NMDA receptor antagonist with multimodal activity under development for the treatment of Alzheimer’s disease (AD) agitation and other CNS disorders.
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 28, 2022
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Axsome Therapeutics Initiates Advance-2 Phase 3 Trial of AXS-05 in Alzheimer’s Disease Agitation
Details : AXS-05 (dextromethorphan-bupropion) is a novel, oral, patent-protected, investigational NMDA receptor antagonist with multimodal activity under development for treatment of AD agitation and other CNS disorders.
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 08, 2022
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Results with AXS-05 (dextromethorphan-bupropion), demonstrate rapid reductions in anhedonic symptoms, and are consistent with observed improvements in patient functioning and quality of life associated with treatment with AXS-05 in clinical trials.
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 02, 2022
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AXS-05 (dextromethorphan) was generally well tolerated in the trial. The most common adverse events with AXS-05 were dizziness, nausea, dry mouth, decreased appetite, and anxiety. AXS-05 was not associated with psychotomimetic effects, weight gain, or se...
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 18, 2022
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Hercules Capital
Deal Size : Undisclosed
Deal Type : Financing
Axsome Therapeutics Expands Term Loan Facility with Hercules Capital to $300 Million
Details : Under the terms of the amendment, the size of the term loan facility was increased and the amount available at the Company’s option immediately upon approval of AXS-05 in major depressive disorder was increased.
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 18, 2021
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Hercules Capital
Deal Size : Undisclosed
Deal Type : Financing
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AXS-05 (dextromethorphan-bupropion) is a novel, oral, patent-protected, investigational NMDA receptor antagonist with multimodal activity under development for the treatment of major depressive disorder and other central nervous system (CNS) disorders.
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 23, 2021
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AXS-05 is a novel, oral, patent-protected, investigational NMDA receptor antagonist with multimodal activity under development for the treatment of Alzheimer’s disease agitation, major depressive disorder, and other central nervous system (CNS) disorde...
Brand Name : AXS-05
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 03, 2020
Lead Product(s) : Dextromethorphan,Bupropion Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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