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    [{"orgOrder":0,"company":"DiaMedica Therapeutics","sponsor":"Guggenheim Securities","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Public Offering","leadProduct":"Rinvecalinase Alpha","moa":"KLK1","graph1":"Nephrology","graph2":"Phase II","graph3":"DiaMedica Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"DiaMedica Therapeutics \/ Guggenheim Securities","highestDevelopmentStatusID":"8","companyTruncated":"DiaMedica Therapeutics \/ Guggenheim Securities"},{"orgOrder":0,"company":"DiaMedica Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Rinvecalinase Alpha","moa":"KLK1","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II\/ 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"DiaMedica Therapeutics \/ Craig-Hallum Capital Group","highestDevelopmentStatusID":"9","companyTruncated":"DiaMedica Therapeutics \/ Craig-Hallum Capital Group"},{"orgOrder":0,"company":"DiaMedica Therapeutics","sponsor":"Craig-Hallum Capital Group","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Enzyme","year":"2023","type":"Private Placement","leadProduct":"Rinvecalinase Alpha","moa":"KLK1","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II\/ Phase III","graph3":"DiaMedica Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"DiaMedica Therapeutics \/ Craig-Hallum Capital Group","highestDevelopmentStatusID":"9","companyTruncated":"DiaMedica Therapeutics \/ Craig-Hallum Capital Group"}]

    Find Clinical Drug Pipeline Developments & Deals by DiaMedica Therapeutics

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                            01

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Doses First Patient in Phase 2 DM199 Trial for Preeclampsia

                            Details : DM199 (rinvecalinase alfa) is a form of human tissue kallikrein-1. Currently, it is being evaluated in the early-stage clinical trials studies for the treatment of Preeclampsia.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 13, 2024

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Receives Approval to Start Phase 2 DM199 Trial For Preeclampsia

                            Details : DM199 (rinvecalinase alfa) is a form of human tissue kallikrein-1. Currently, it is being evaluated in the early-stage clinical trials studies for the treatment of Preeclampsia.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 10, 2024

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Undisclosed

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Announces $11.8 Million Private Placement

                            Details : The net proceeds will be used to advance the clinical development of DM199 (rinvecalinase alfa) recombinant form of rhKLK1. It is being evaluated for the treatment of acute ischemic stroke.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            June 26, 2024

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Undisclosed

                            Deal Type : Private Placement

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                            04

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Announces Expansion of DM199 (Rinvecalinase Alfa) Program into Preeclampsia

                            Details : DM199 (rinvecalinase alfa) is a form of human tissue kallikrein-1. Currently, it is being evaluated in the early-stage clinical trials studies for the treatment of Preeclampsia.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            June 26, 2024

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            DiaMedica Therapeutics

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                            Pharma Live Expo
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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Craig-Hallum Capital Group

                            Deal Size : $37.5 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Announces Closing of $37.5 Million Private Placement

                            Details : The Company intends to use the net proceeds to continue its clinical and product development activities for DM199 (recombinant human tissue kallikrein), including its pivotal Phase 2/3, ReMEDy2 clinical trial to treat acute ischemic stroke patients.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            June 26, 2023

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Craig-Hallum Capital Group

                            Deal Size : $37.5 million

                            Deal Type : Private Placement

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                            06

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Announces that the FDA has Removed the Clinical Hold on DM199 Phase 2/3 Trial for Ische...

                            Details : DM199 is a recombinant human tissue kallikrein-1. KLK1 is a serine protease that plays an important role in the regulation of diverse physiological processes including blood flow, oxidative stress and neurogenesis, which is investigated for Ischemic Stro...

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            June 21, 2023

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Craig-Hallum Capital Group

                            Deal Size : $37.5 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Announces $37.5 Million Private Placement

                            Details : The Company intends to use the net proceeds to continue its clinical and product development activities for DM199 (recombinant human tissue kallikrein), including its pivotal Phase 2/3, ReMEDy2 clinical trial to treat acute ischemic stroke patients.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            June 21, 2023

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Craig-Hallum Capital Group

                            Deal Size : $37.5 million

                            Deal Type : Private Placement

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                            08

                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            No Remedy For Diamedica As FDA Maintains Hold On Stroke Trial

                            Details : DM199 is a recombinant human tissue kallikrein-1. KLK1 is a serine protease that plays an important role in the regulation of diverse physiological processes including blood flow, inflammation, fibrosis, oxidative stress and neurogenesis.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 26, 2022

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            DiaMedica Therapeutics

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                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Announces Clinical Hold of its Phase 2/3 ReMEDy2 Clinical Trial for DM199

                            Details : Clinical Hold has placed on DM199, a recombinant form of human tissue KLK1, based on submission of three serious adverse event reports to the FDA related to clinically significant, transient hypotension (low blood pressure) occurring shortly after initia...

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            June 07, 2022

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            DiaMedica Therapeutics

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                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DiaMedica Therapeutics Hosting Key Opinion Leader Webinar on DM199 for Treatment of Acute Ischemic Stroke

                            Details : DM199 is a recombinant (synthetic) form of the human tissue kallikrein-1 (KLK1). DiaMedica plans to submit an investigational new drug (IND) application to the FDA for the phase 2/3 study in the first quarter of 2021.

                            Product Name : DM199

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 03, 2021

                            Lead Product(s) : Rinvecalinase Alpha

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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