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    [{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Panacea Venture","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Series A Financing","leadProduct":"DT-9081","moa":"EP4R","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.040000000000000001,"dosageForm":"Inhalation","sponsorNew":"Domain Therapeutics \/ Panacea Venture","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Panacea Venture"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Collaboration","leadProduct":"5-Methyltetrazole","moa":"A2AR\/A2BR","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0.26000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.26000000000000001,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Merck","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Merck"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"DT-9081","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"DT-9081","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"DT-9081","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Domain Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"DT-9045","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Domain Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Chime Biologics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Agreement","leadProduct":"DT-7012","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Domain Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Domain Therapeutics \/ Domain Therapeutics"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Agence Nationale de la Recherche","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Funding","leadProduct":"DT-7012","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Domain Therapeutics \/ Agence Nationale de la Recherche","highestDevelopmentStatusID":"4","companyTruncated":"Domain Therapeutics \/ Agence Nationale de la Recherche"}]

    Find Clinical Drug Pipeline Developments & Deals by Domain Therapeutics

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                            01

                            Domain Therapeutics

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                            Lead Product(s) : DT-9045

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics to Present DT-9045 Data, a Novel Modulator for Immuno-oncology

                            Details : DT-9045 is a novel protease-activated receptor 2 (PAR2) negative allosteric modulator, small molecule drug candidate. It is being evaluated for the treatment of cancer.

                            Brand Name : DT-9045

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 26, 2024

                            Lead Product(s) : DT-9045

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Chime Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Domain Therapeutics and Chime Announce Manufacturing Deal for Anti-Ccr8 Cancer Antibody

                            Details : Through the agreement, the company will focus on the clinical development of DT-7012, a CCR8 antibody candidate. Currently, it is being evaluated in preclinical trial studies for Neoplasms.

                            Brand Name : DT-7012

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 12, 2024

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Chime Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            03

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Agence Nationale de la Recherche

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Domain Therapeutics Awarded Grant To Progress CCR8 Antibody Candidate

                            Details : A grant supports clinical progress of DT-7012, an anti-CCR8 monoclonal antibody, in preclinical studies for cutaneous T-cell lymphoma and other neoplasms.

                            Brand Name : DT-7012

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            January 25, 2024

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Agence Nationale de la Recherche

                            Deal Size : Undisclosed

                            Deal Type : Funding

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                            04

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics Announces First Patient Dosed With DT-9081 In Phase I Clinical Study In Patients With Adva...

                            Details : DT-9081 is an oral small molecule product which, by blocking the EP4 receptor present on immune cells, is able to reverse the prostaglandin E2 (PGE2)-mediated immunosuppression triggered by some tumors to bypass the immune system.

                            Brand Name : DT-9081

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 05, 2023

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics To Progress Into Clinical Trials With Its EP4R Antagonist DT-9081 In Solid Tumors

                            Details : DT-9081 is an oral small molecule drug candidate, which is able to reverse the prostaglandin E2 (PGE2)-mediated immunosuppression triggered by some tumors to bypass the immune system, by blocking the EP4 receptor present on immune cells.

                            Brand Name : DT-9081

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 19, 2022

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : DT-9081,Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics To Present New Data On Its EP4R and CCR8 Antagonists at 2022 SITC Annual Meeting

                            Details : DT-9081 is a selective EP4 receptor antagonist which synergizes with immune checkpoint inhibitors to induce complete responses in syngeneic murine cancer models.

                            Brand Name : DT-9081

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 06, 2022

                            Lead Product(s) : DT-9081,Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

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                            Lead Product(s) : 5-Methyltetrazole

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : $261.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Domain Therapeutics Receives a Single Digit Multimillion Development Milestone Payment from Merck For M1069 Cl...

                            Details : A2a/A2b antagonist candidate, M1069, a first-in-human study to investigate the safety, tolerability, PK/PD and clinical activity in patients with metastatic or locally advanced unresectable solid tumors.

                            Brand Name : M1069

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            June 28, 2022

                            Lead Product(s) : 5-Methyltetrazole

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : $261.0 million

                            Deal Type : Collaboration

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                            08

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Panacea Venture

                            Deal Size : $42.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            Domain Therapeutics Raises $42m Series A Financing

                            Details : Domain Therapeutics will use the proceeds to i) conduct the clinical development of its EP4R antagonist, DT-9081, ii) advance two additional GPCR programs, and iii) progress its discovery-stage pipeline of a number of first-in-class assets targeting GPCR...

                            Brand Name : DT-9081

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 10, 2022

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Panacea Venture

                            Deal Size : $42.0 million

                            Deal Type : Series A Financing

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