Novartis Ends License Agreement for Cancer Drug with Allarity Due to Non-Payment
Details : The agreement provided Allarity with TKI258 (dovitinib), an oral multikinase inhibitor targeting FGF receptors, PDGF receptors and VEGF receptors, for the treatment of renal cancer.
Product Name : TKI258
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 02, 2024
Lead Product(s) : Dovitinib,Stenoparib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Stenoparib is a dual-targeted inhibitor of PARP 1, 2 and tankyrase 1, 2 where dovitinib is a pan-tyrosine kinase inhibitor. The combination may increase the chances of cancer apoptosis and providing synergistic, enhanced antitumor activity.
Product Name : TKI258
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 20, 2023
Lead Product(s) : Dovitinib,Stenoparib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Allarity Therapeutics Provides Update on Dovitinib Program
Details : Allarity has requested a Type C meeting with the FDA to discuss potential clinical paths to support approval of dovitinib in view of the regulatory agency’s recent Refusal to File letters for the Company’s NDA and related PMA.
Product Name : TKI258
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 15, 2022
Lead Product(s) : Dovitinib,Stenoparib
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Allarity Therapeutics Refocuses Oncology Pipeline Strategy Towards Combination Therapies
Details : The DRP® platform has proven its ability to provide a statistically significant prediction of clinical outcome from drug treatment in cancer patients in 37 out of 47 clinical studies that were examined including ongoing, prospective Phase 2 trials of St...
Product Name : TKI258
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 08, 2022
Lead Product(s) : Dovitinib,Stenoparib
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : NDA is supported by Allarity’s previously-filed pre-market approval submission to the FDA for the Dovitinib-DRP® companion diagnostic to select RCC patients most likely to respond to the drug.
Product Name : Dovitinib-DRP
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 22, 2021
Details : Under the terms of the agreement, Lonza will leverage its capabilities for commercial manufacturing of small-molecules including Dovitinib and oral solid dosage forms to provide Allarity with cGMP compliant drug product supply and regulatory support towa...
Product Name : Dovitinib-DRP
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
September 23, 2021
Details : Dovitinib DRP® companion diagnostic utilizing data from Novartis’ prior Phase III trial of dovitinib in renal cell carcinoma (RCC), which can identify RCC patients that benefit from treatment with dovitinib when compared to alternative treatment with ...
Product Name : Dovitinib-DRP
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
September 16, 2021
Details : Allarity’s focus on pediatric osteosarcoma development is based on the results of two previously reported preclinical studies in which treatment with dovitinib, compared to control treatment (sucrose solution lacking dovitinib).
Product Name : TKI258
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 14, 2021
Details : Allarity’s unique and clinically validated DRP® biomarker technology makes it possible to predict whether a particular cancer patient is likely to benefit from treatment with dovitinib, in addition to a broad range of anti-cancer drugs.
Product Name : Dovitinib-DRP
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 07, 2021
Details : The e-Poster provides new details of the Dovitinib-DRP® companion diagnostic, which is used to select cancer patients most likely to respond to the pan-targeted kinase inhibitor (pan-TKI) dovitinib.
Product Name : Dovitinib-DRP
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 29, 2021