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    [{"orgOrder":0,"company":"Drug Farm","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"CHINA","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"8-Bromo-pet-cyclic gmps","moa":"ALPK1","graph1":"Undisclosed","graph2":"Phase I","graph3":"Drug Farm","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Drug Farm \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Drug Farm \/ Undisclosed"},{"orgOrder":0,"company":"Drug Farm","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"CHINA","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"8-Bromo-pet-cyclic gmps","moa":"ALPK1","graph1":"Undisclosed","graph2":"Phase I","graph3":"Drug Farm","amount2":0,"highestDevelopmentShortName":"Ph 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Undisclosed"},{"orgOrder":0,"company":"Drug Farm","sponsor":"Cincinnati Children\u2019s Hospital Medical Center","pharmaFlowCategory":"D","therapeuticArea":"Hematology","country":"CHINA","productType":"Miscellaneous","year":"2025","type":"Agreement","leadProduct":"8-Bromo-pet-cyclic gmps","moa":"ALPK1","graph1":"Hematology","graph2":"Phase I","graph3":"Drug Farm","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hematology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Drug Farm \/ Cincinnati Children\u2019s Hospital Medical Center","highestDevelopmentStatusID":"6","companyTruncated":"Drug Farm \/ Cincinnati Children\u2019s Hospital Medical Center"}]

    Find Clinical Drug Pipeline Developments & Deals by Drug Farm

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                            01

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Hematology

                            Study Phase : Phase I

                            Sponsor : Cincinnati Children’s Hospital Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Drug Farm Partners CCH to Explore ALPK1 Inhibitor for Heart Disease & Blood Cancers

                            Details : Under the terms of the agreement, Drug Farm will provide DF-003 to the CCHMC, a small molecule targeting ALPK1, for clonal hematopoiesis of indeterminate potential (CHIP).

                            Product Name : DF-003

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            September 23, 2025

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase I

                            Sponsor : Cincinnati Children’s Hospital Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            Drug Farm

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                            Lead Product(s) : DF-006

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Xiamen Amoytop Biotech Co., Ltd

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Drug Farm and Amoytop Ink Option Deal for DF-006 To Treat Hepatitis B and Liver Cancer

                            Details : The collaboration aims to advance the clinical development of Drug Farm’s first-in-class ALPK1 agonist, DF-006 in the field of ​hepatitis B and hepatocellular cancer in the ​Greater China region.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            May 27, 2025

                            Lead Product(s) : DF-006

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Xiamen Amoytop Biotech Co., Ltd

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : National Institute of Allergy and Infectious Diseases

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Drug Farm and NIH Partner to Develop Treatment for ROSAH Syndrome

                            Details : Under the terms of the agreement, Drug Farm will partner with NIAID to develop DF-003, a precision-targeted drug for the treatment of ROSAH syndrome.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            December 19, 2024

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : National Institute of Allergy and Infectious Diseases

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            04

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Farm Gets IND Clearance for Phase 1b of DF-003 in ROSAH Syndrome Patients

                            Details : DF-003 is a first-in-class, oral, potent, highly selective alpha-kinase 1 (ALPK1) inhibitor, which is curently being evaluated for the treatment of ROSAH syndrome.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 17, 2024

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome Patients

                            Details : DF-003 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 02, 2024

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Farm Receives Rare Pediatric Disease Designation for Df-003 To Treat Rosah Syndrome

                            Details : DF-003, a potent small molecule inhibitor of ALPK1, is in Phase 1 development for the treatment of ROSAH Syndrome, targeting immunity and inflammation.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 13, 2024

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Drug Farm

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                            Lead Product(s) : DF-006

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Farm Doses First Patient in Part 3 of Phase 1 Chronic Hepatitis B Trial

                            Details : DF-006 is a first-in-class innate immunity modulator that act as ALPK1 agonist, which is demonstrated treatment-naïve and virologically suppressed patients with chronic hepatitis B infection.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            September 26, 2023

                            Lead Product(s) : DF-006

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Farm Doses First Patient in Phase 1 Trial for ALPK1 Inhibitor, DF-003

                            Details : DF-003, discovered through Drug Farms’ IDInVivo and MedChem5 platform technologies, is an investigational small molecule drug that inhibits alpha-kinase 1 (ALPK1), a key target regulating inflammation pathways that underly disease pathology in cardio-r...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 19, 2023

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluating the Safety, Tolerability, and Pharmacokinetics of DF-003 in Healthy Subjects

                            Details : DF-003 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 18, 2023

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Drug Farm

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                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Farm Announces IND Clearance by U.S. FDA Enabling Phase 1 Initiation for First-in-Class Oral ALPK1 Select...

                            Details : DF-003 is a highly potent first-in-class, oral investigational inhibitor of ALPK1 and the ALPK1 T237M driver mutation that causes disease in ROSAH syndrome patients.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 29, 2023

                            Lead Product(s) : 8-Bromo-pet-cyclic gmps

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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