Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : DB-1418
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Avenzo Therapeutics
Deal Size : $1,200.0 million
Deal Type : Licensing Agreement
Avenzo, DualityBio Sign License for EGFR/HER3 Antibody-Drug Conjugate
Details : Under the licensing agreement, Venzo will develop, manufacture and commercialize AVZO-1418 (DB-1418), a potential best-in-class bispecific ADC for treating neoplasms.
Product Name : AVZO-1418
Product Type : Antibody-drug Conjugate
Upfront Cash : $50.0 million
January 07, 2025
Lead Product(s) : DB-1418
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Avenzo Therapeutics
Deal Size : $1,200.0 million
Deal Type : Licensing Agreement
Lead Product(s) : DB-1312,Tislelizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : BeiGene
Deal Size : $1,300.0 million
Deal Type : Licensing Agreement
Nona Biosciences Updates on DualityBio's ADC Collaboration with BeiGene
Details : BeiGene has exercised its exclusive option to acquire global development, manufacturing, and commercialization rights for an ADC, BG-C9074 (DB-1312) from DualityBio.
Product Name : DB-1312
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
January 03, 2025
Lead Product(s) : DB-1312,Tislelizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : BeiGene
Deal Size : $1,300.0 million
Deal Type : Licensing Agreement
Duality Biologics Announces B7H4 ADC Milestone Achievement and License Exercise by BeiGene
Details : Under the agreement, BeiGene will acquire an exclusive option for a global clinical and commercial license to DB-1312, an investigational antibody-drug conjugate therapy for solid tumors.
Product Name : DB-1312
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
December 30, 2024
Lead Product(s) : DB-1324
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : GSK
Deal Size : Undisclosed
Deal Type : Agreement
GSK Turns Back to China in Another Potential $1B+ ADC Deal
Details : GSK gains an exclusive option to obtain a license to develop and commercialize a potentially best-in-class ADC candidate, DB-1324 worldwide (excluding mainland China, Hong Kong, and Macau).
Product Name : DB-1324
Product Type : Antibody-drug Conjugate
Upfront Cash : $30.0 million
December 04, 2024
Lead Product(s) : DB-1324
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : GSK
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Discovery Platform
Sponsor : Adcendo
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Duality Biologics Expands Adcendo Collaboration via Strategic License Agreement
Details : Adcendo exercises its option to utilize Duality's platform to further enhance its first-in-class ADC pipeline and develop highly differentiated novel ADCs for the treatment of hard-to-treat cancers.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Undisclosed
November 25, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Discovery Platform
Sponsor : Adcendo
Deal Size : Undisclosed
Deal Type : Licensing Agreement
BioNTech and DualityBio Initiate Pivotal Phase 3 Trial of BNT323/DB-1303 in MBC
Details : BNT323 (DB-1303) is a third-generation topoisomerase-1 inhibitor-based ADC targeting HER2. It is under phase 3 clinical development for the treatment of metastatic breast cancer.
Product Name : BNT323
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
January 22, 2024
Lead Product(s) : DB-1312
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : BeiGene
Deal Size : $1,300.0 million
Deal Type : Agreement
Details : Under the agreement, BeiGene will acquire an exclusive option for a global clinical and commercial license to DB-1312, an investigational, preclinical antibody-drug conjugate therapy for solid tumors and DualityBio will continue preclinical research and ...
Product Name : DB-1312
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
October 07, 2023
Lead Product(s) : DB-1312
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : BeiGene
Deal Size : $1,300.0 million
Deal Type : Agreement
Lead Product(s) : DB-1303
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $1,670.0 million
Deal Type : Expanded Collaboration
Details : Under the expanded collaboration, BioNTech will develop, manufacture and commercialize DB-1305, a third generation Trop2 ADC molecule built from DualityBio's proprietary DITAC platform, globally, excluding Mainland China, Hong Kong and Macau Special Admi...
Product Name : BNT323
Product Type : Antibody-drug Conjugate
Upfront Cash : $170.0 million
July 08, 2023
Lead Product(s) : DB-1303
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $1,670.0 million
Deal Type : Expanded Collaboration
Details : Under the agreement, new targets will be evaluated with Duality’s linker-payload platform, designed to generate ADCs with superior safety profiles, sustainable payload delivery and release in tumors, and efficient bystander killing of antigen low and n...
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Undisclosed
May 30, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Adcendo
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Adcendo ApS Announces License Agreement with Duality Biologics on Next-generation ADC Platform
Details : Antibody Drug Conjugates (ADC) are a class of highly potent biopharmaceutical drug composed of a targeting antibody linked to a biologically active drug or cytotoxic compound. uPARAP is a novel cancer target overexpressed on the cell surface of mesenchym...
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
May 01, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Adcendo
Deal Size : Undisclosed
Deal Type : Licensing Agreement