[{"orgOrder":0,"company":"Dynacure","sponsor":"Perceptive Advisors","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Oligonucleotide","year":"2020","type":"Series C Financing","leadProduct":"DYN101","moa":"DNM2","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Perceptive Advisors","highestDevelopmentStatusID":"7","companyTruncated":"Dynacure \/ Perceptive Advisors"},{"orgOrder":0,"company":"Dynacure","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"DYN101","moa":"DNM2","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Dynacure \/ Inapplicable"},{"orgOrder":0,"company":"Dynacure","sponsor":"Nippon Shinyaku","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Oligonucleotide","year":"2021","type":"Agreement","leadProduct":"DYN101","moa":"DNM2","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Nippon Shinyaku","highestDevelopmentStatusID":"7","companyTruncated":"Dynacure \/ Nippon Shinyaku"},{"orgOrder":0,"company":"Dynacure","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"DYN101","moa":"DNM2","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Dynacure \/ Inapplicable"},{"orgOrder":0,"company":"Dynacure","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"DYN101","moa":"DNM2","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Dynacure \/ Inapplicable"},{"orgOrder":0,"company":"Dynacure","sponsor":"Flamingo Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"BELGIUM","productType":"Oligonucleotide","year":"2023","type":"Merger","leadProduct":"Danvatirsen","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Dynacure","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Dynacure \/ Dynacure","highestDevelopmentStatusID":"8","companyTruncated":"Dynacure \/ Dynacure"}]

Find Clinical Drug Pipeline Developments & Deals by Dynacure

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : The combined oncology company will advance Flamingo's lead programs, Danvatirsen (antisence oligonucleotide) in a Phase II trial PEMDA-HN in Head & Neck cancer (danvatirsen in combination with pembrolizumab) and other indications; and FTX-001 targeting M...

                          Product Name : AZD9150

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          March 02, 2023

                          Lead Product(s) : Danvatirsen,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Flamingo Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : Fast Track Designation recieved for DYN101,an investigational antisense product candidate designed to reduce the expression of dynamin 2 protein for the treatment of Myotubular and Centronuclear Myopathies.

                          Product Name : DYN101

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          January 06, 2022

                          Lead Product(s) : DYN101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : Under the terms of the agreement, Nippon Shinyaku has secured opt-in rights to exclusively pursue the development and commercialization of DYN101 in Japan depending on analysis of interim data from the Phase 1/2 study, UNITE-CNM.

                          Product Name : DYN101

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          November 10, 2021

                          Lead Product(s) : DYN101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Nippon Shinyaku

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          04

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : U.S. Food and Drug Administration (FDA) has granted rare pediatric disease designation for DYN101, an investigational antisense medicine designed to modulate the expression of dynamin 2 (DNM2), for the treatment of Myotubular and Centronuclear Myopathies...

                          Product Name : DYN101

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          July 30, 2020

                          Lead Product(s) : DYN101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : Funding supports ongoing Phase 1 / 2 'Unite-CNM' study of DYN101 in Patients with Myotubular and Centronuclear Myopathies.

                          Product Name : DYN101

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          April 02, 2020

                          Lead Product(s) : DYN101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Perceptive Advisors

                          Deal Size : $54.6 million

                          Deal Type : Series C Financing

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                          06

                          Pharma Europe
                          Not Confirmed
                          Pharma Europe
                          Not Confirmed

                          Details : This clinical trial, based on Ionis' technology platform, is the first investigational study testing an antisense medicine to treat Centronuclear Myopathies.

                          Product Name : DYN101

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          March 05, 2020

                          Lead Product(s) : DYN101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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