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    [{"orgOrder":0,"company":"Elpiscience","sponsor":"Trigr","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Collaboration","leadProduct":"TR009","moa":"Dll4-Notch1","graph1":"Oncology","graph2":"Phase I","graph3":"Elpiscience","amount2":0.12,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.12,"dosageForm":"","sponsorNew":"Elpiscience \/ Elpiscience Biopharmaceuticals","highestDevelopmentStatusID":"6","companyTruncated":"Elpiscience \/ Elpiscience Biopharmaceuticals"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Greater Bay Area Homeland Development Fund","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Series C Financing","leadProduct":"ES002","moa":"CD39 ATPase","graph1":"Oncology","graph2":"Preclinical","graph3":"Elpiscience","amount2":0.11,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0.11,"dosageForm":"","sponsorNew":"Elpiscience \/ Greater Bay Area Homeland Development Fund","highestDevelopmentStatusID":"4","companyTruncated":"Elpiscience \/ Greater Bay Area Homeland Development Fund"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Asciminib","moa":"Dll4-Notch1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ES014","moa":"CD39","graph1":"Oncology","graph2":"IND Enabling","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ES005","moa":"LAG3","graph1":"Oncology","graph2":"Preclinical","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ES014","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"ES014","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"ES009","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Elpiscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Elpiscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Elpiscience \/ Not Applicable"},{"orgOrder":0,"company":"Elpiscience","sponsor":"Astellas Pharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Collaboration","leadProduct":"ES019","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"Elpiscience","amount2":1.74,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":1.74,"dosageForm":"","sponsorNew":"Elpiscience \/ Astellas Pharma","highestDevelopmentStatusID":"4","companyTruncated":"Elpiscience \/ Astellas Pharma"}]

    Find Clinical Drug Pipeline Developments & Deals by Elpiscience

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                            01

                            Elpiscience

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                            Lead Product(s) : ES019

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Astellas Pharma

                            Deal Size : $1,737.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Elpiscience and Astellas Enter into Research Collaboration and License Agreement for Novel Bispecific Macropha...

                            Details : The collaboration aims to conduct early-stage research for novel bi-specific macrophage engagers, ES019, an anti-PD-L1/SIRPα bispecific antibody, and another program.

                            Brand Name : ES019

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 27, 2023

                            Lead Product(s) : ES019

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Astellas Pharma

                            Deal Size : $1,737.0 million

                            Deal Type : Collaboration

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                            02

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                            Lead Product(s) : ES009

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elpiscience Announces First Patient Dosed for Phase 1 Clinical Trial of Anti-LILRB2 Antibody ES009 in Australi...

                            Details : ES009 specifically binds to a unique epitope on human LILRB2 and potently blocks LILRB2 binding to multiple ligands, which is investigated for the treatment of cancer.

                            Brand Name : ES009

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 26, 2023

                            Lead Product(s) : ES009

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

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                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elpiscience Announces First Patient Dosed for Phase 1 Clinical Trial of First-in-Class Anti-CD39xTGF-β Bispec...

                            Details : ES014 is a first-in-class anti-CD39xTGF-β bispecific antibody (bsAb) that simultaneously targets the adenosine and TGF-β pathways, two major immunosuppressive mechanisms in the tumor microenvironment (TME).

                            Brand Name : ES014

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 27, 2023

                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

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                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elpiscience Announces CDE IND Clearance of ES014, a First in Class Anti-CD39xTGF-β Bispecific Antibody for Pa...

                            Details : ES014 is a first-in-class anti-CD39xTGF-β bispecific antibody (bsAb) that simultaneously targets the CD39-adenosine and TGF-β pathways to synergistically activates T cells for ICB-resistant cancer immunotherapy

                            Brand Name : ES014

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 22, 2022

                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

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                            Lead Product(s) : ES005

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elpiscience Announces Five Poster Presentations at Society for Immunotherapy of Cancer (SITC) 2022 Annual Meet...

                            Details : ES005, a high affinity anti-LAG3 monoclonal antibody, inhibits the interactions between LAG3 and multiple ligands and enhances anti-tumor activity of T cells in preclinical models.

                            Brand Name : ES005

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 21, 2022

                            Lead Product(s) : ES005

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elpiscience Announces FDA IND Clearance of ES014, a First-in-Class Anti-CD39xTGF-β Bispecific Antibody for Pa...

                            Details : ES014 is a first-in-class anti-CD39xTGF-β bispecific antibody (bsAb) that simultaneously targets the CD39-adenosine and TGF-β pathways, two major immunosuppressive mechanisms in the tumor microenvironment.

                            Brand Name : ES014

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 09, 2022

                            Lead Product(s) : ES014

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

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                            Lead Product(s) : Asciminib,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Positive Interim ES104 Phase 2 Data Reported in Combination with Paclitaxel in Biliary Tract Cancers

                            Details : ES104 (asciminib) demonstrated, 42% overall response rate (ORR) based on 10 patients with Partial Responses (PRs), including 9 PRs confirmed by RECIST 1.1 and 1 PR pending confirmation.

                            Brand Name : ES104

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 05, 2022

                            Lead Product(s) : Asciminib,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

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                            Lead Product(s) : ES002

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Greater Bay Area Homeland Development Fund

                            Deal Size : $105.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Elpiscience Announces the Completion of $105 Million Series C Financing

                            Details : ES002, a potentially best-in-class anti-CD39 antibody, binds to CD39 with sub-nanomolar binding affinity and effectively blocks CD39 ATPase activity. ES002 exhibits a strong efficacy in tumor growth inhibition in vivo.

                            Brand Name : ES002

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            May 13, 2021

                            Lead Product(s) : ES002

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Greater Bay Area Homeland Development Fund

                            Deal Size : $105.0 million

                            Deal Type : Series C Financing

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                            09

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                            Lead Product(s) : Asciminib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Trigr

                            Deal Size : $117.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            TRIGR Therapeutics and Elpiscience Biopharmaceuticals Announce $117 Million Exclusive China Licensing Transact...

                            Details : Elpiscience obtains the exclusive development and commercialization rights of TR009 for Greater China across all oncology indications and will lead the clinical development and commercialization to accelerate the path to approval of TR009 in its territor...

                            Brand Name : ABL001

                            Molecule Type : Large molecule

                            Upfront Cash : $7.0 million

                            January 20, 2021

                            Lead Product(s) : Asciminib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Trigr

                            Deal Size : $117.0 million

                            Deal Type : Collaboration

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