Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Tepotinib
Therapeutic Area : Oncology
Study Phase : Approved
Recipient : Foundation Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Approves FoundationOne®Liquid CDx for TEPMETKO® in MET Exon 14 NSCLC
Details : Tepmetko (tepotinib) is a kinase inhibitor indicated for the treatment of adult patients with NSCLC harboring mesenchymalepithelial transition (MET) exon 14 skipping alterations.
Brand Name : Tepmetko
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 18, 2024
Lead Product(s) : Tepotinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Recipient : Foundation Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Merck Group
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Xevinapant (formerly known as Debio 1143) is an investigational first-in-class potent oral small-molecule IAP (inhibitor of apoptosis protein) inhibitor for the treatment of LA SCCHN.
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 07, 2022
Lead Product(s) : Xevinapant
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Merck Group
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Avelumab
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Pfizer Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
EMD Serono to Present Latest Research From Oncology Portfolio at ASCO 2022
Details : BAVENCIO (avelumab), New analyses of long-term data from study of BAVENCIO as treatment in advanced UC, including data from subgroups defined by best response to first-line chemotherapy and in patients who did or did not receive second-line treatment.
Brand Name : Bavencio
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 26, 2022
Lead Product(s) : Avelumab
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Pfizer Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Evobrutinib,Interferon Beta 1a
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
EMD Serono Shares Advances in MS Portfolio with Key Efficacy and Safety Data at AAN 2022
Details : New Phase II data show evobrutinib sustained low annualized relapse rates (ARRs) and had no new safety signals at 2.5 years – the longest follow-up of any Bruton’s tyrosine kinase inhibitor in multiple sclerosis (MS).
Brand Name : M2951
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 31, 2022
Lead Product(s) : Evobrutinib,Interferon Beta 1a
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Avelumab
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The safety profile for BAVENCIO was consistent with the overall JAVELIN monotherapy clinical development program, with no new safety signals. Patients continued treatment until disease progression, unacceptable toxicity or any other criteria for withdraw...
Brand Name : Bavencio
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 18, 2022
Lead Product(s) : Avelumab
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cladribine
Therapeutic Area : Immunology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : 81.2% of cladribine tablets-treated patients did not require an ambulatory device. CLASSIC-MS investigated the long-term efficacy in 435 patients with RMS – 90.6% of whom were exposed to cladribine tablets during the CLARITY and CLARITY Extension trial...
Brand Name : Mavenclad
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 13, 2021
Lead Product(s) : Cladribine
Therapeutic Area : Immunology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Evobrutinib
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
EMD Serono Completes Enrollment of Evobrutinib Phase III Clinical Trials Ahead of ECTRIMS 2021
Details : Investigational evobrutinib is the first Bruton’s tyrosine kinase (BTK) inhibitor to complete Phase III clinical trial enrollment in relapsing multiple sclerosis (RMS).
Brand Name : M2951
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 04, 2021
Lead Product(s) : Evobrutinib
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BAVENCIO is a human anti-programmed death ligand-1 (PD-L1) antibody and is part of a class of immunotherapy drugs called immune checkpoint inhibitors.
Brand Name : Bavencio
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 29, 2021
Lead Product(s) : Evobrutinib
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Data presented at AAN shows investigational evobrutinib significantly reduced blood neurofilament light chain (NfL) levels, which may predict future brain atrophy and disease progression, in patients with relapsing MS.
Brand Name : M2951
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 16, 2021
Lead Product(s) : Evobrutinib
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Berzosertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : EMD Serono also initiated a global Phase II study to further assess berzosertib in combination with topotecan for the treatment of relapsed, platinum-resistant SCLC (DDRiver SCLC 250).
Brand Name : M6620
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 12, 2021
Lead Product(s) : Berzosertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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